DGAT2 (diacylglycerol O-acyltransferase 2)

2017-08-01  

Identity

HGNC
DGAT2
LOCATION
11q13.5
LOCUSID
84649
ALIAS
ARAT,GS1999FULL,HMFN1045
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84649
MIM: 606983
HGNC: 16940
Ensembl: ENSG00000062282

Variants:

dbSNP: 84649
ClinVar: 84649
TCGA: ENSG00000062282
COSMIC: DGAT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000062282ENST00000228027Q96PD7
ENSG00000062282ENST00000376262Q96PD7
ENSG00000062282ENST00000603276S4R383
ENSG00000062282ENST00000604733S4R3S3
ENSG00000062282ENST00000604935S4R3Z3
ENSG00000062282ENST00000605099S4R449

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycerolipid metabolismKEGGko00561
Glycerolipid metabolismKEGGhsa00561
Metabolic pathwaysKEGGhsa01100
Fat digestion and absorptionKEGGko04975
Fat digestion and absorptionKEGGhsa04975
Triacylglycerol biosynthesisKEGGhsa_M00089
Triacylglycerol biosynthesisKEGGM00089
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Acyl chain remodeling of DAG and TAGREACTOMER-HSA-1482883

References

Pubmed IDYearTitleCitations
187578362008Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis.284
190499832009The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria.113
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
152581942004Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells.44
179402172007Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle.34
234893672013Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia.33
227480692012Diacylglycerol acyltransferase 2 acts upstream of diacylglycerol acyltransferase 1 and utilizes nascent diglycerides and de novo synthesized fatty acids in HepG2 cells.32
189805782009The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans.25
175047632007Sequential regulation of diacylglycerol acyltransferase 2 expression by CAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPalpha during adipogenesis.21

Citation

Dessen P

DGAT2 (diacylglycerol O-acyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/57006/dgat2