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DGKD (diacylglycerol kinase delta)

Identity

Alias (NCBI)DGK-delta
DGKdelta
dgkd-2
HGNC (Hugo) DGKD
HGNC Alias symbKIAA0145
DGKdelta
HGNC Alias namediglyceride kinase
HGNC Previous namediacylglycerol kinase, delta (130kD)
 diacylglycerol kinase, delta 130kDa
LocusID (NCBI) 8527
Atlas_Id 54253
Location 2q37.1  [Link to chromosome band 2q37]
Location_base_pair Starts at 233354494 and ends at 233472098 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BRD9 (5p15.33) / DGKD (2q37.1)CDKN2B (9p21.3) / DGKD (2q37.1)DGKD (2q37.1) / ATG16L1 (2q37.1)
DGKD (2q37.1) / SAG (2q37.1)DGKD (2q37.1) / SP140 (2q37.1)DGKD (2q37.1) / SPP2 (2q37.1)
CDKN2B 9p21.3 / DGKD 2q37.1DGKD 2q37.1 / ATG16L1 2q37.1DGKD 2q37.1 / SAG 2q37.1
DGKD 2q37.1 / SP140 2q37.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  DGKD/ATG16L1 (2q37)
DGKD/SAG (2q37)
DGKD/SAG (2q37)
DGKD/SP140 (2q37)
DGKD/SPP2 (2q37)
t(2;9)(q37;p21) CDKN2B/DGKD

External links

Nomenclature
HGNC (Hugo)DGKD   2851
Cards
Entrez_Gene (NCBI)DGKD    diacylglycerol kinase delta
AliasesDGK-delta; DGKdelta; dgkd-2
GeneCards (Weizmann)DGKD
Ensembl hg19 (Hinxton)ENSG00000077044 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000077044 [Gene_View]  ENSG00000077044 [Sequence]  chr2:233354494-233472098 [Contig_View]  DGKD [Vega]
ICGC DataPortalENSG00000077044
TCGA cBioPortalDGKD
AceView (NCBI)DGKD
Genatlas (Paris)DGKD
SOURCE (Princeton)DGKD
Genetics Home Reference (NIH)DGKD
Genomic and cartography
GoldenPath hg38 (UCSC)DGKD  -     chr2:233354494-233472098 +  2q37.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DGKD  -     2q37.1   [Description]    (hg19-Feb_2009)
GoldenPathDGKD - 2q37.1 [CytoView hg19]  DGKD - 2q37.1 [CytoView hg38]
ImmunoBaseENSG00000077044
genome Data Viewer NCBIDGKD [Mapview hg19]  
OMIM601826   
Gene and transcription
Genbank (Entrez)AB078966 AK130440 AK307426 AK308846 AK311044
RefSeq transcript (Entrez)NM_001377259 NM_003648 NM_152879
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DGKD
Alternative Splicing GalleryENSG00000077044
Gene ExpressionDGKD [ NCBI-GEO ]   DGKD [ EBI - ARRAY_EXPRESS ]   DGKD [ SEEK ]   DGKD [ MEM ]
Gene Expression Viewer (FireBrowse)DGKD [ Firebrowse - Broad ]
GenevisibleExpression of DGKD in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8527
GTEX Portal (Tissue expression)DGKD
Human Protein AtlasENSG00000077044-DGKD [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16760   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16760  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16760
Splice isoforms : SwissVarQ16760
Catalytic activity : Enzyme2.7.1.107 [ Enzyme-Expasy ]   2.7.1.1072.7.1.107 [ IntEnz-EBI ]   2.7.1.107 [ BRENDA ]   2.7.1.107 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ16760
Domaine pattern : Prosite (Expaxy)DAGK (PS50146)    PH_DOMAIN (PS50003)    SAM_DOMAIN (PS50105)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)ATP-NAD_kinase_N    DGK    DGK-delta_SAM    Diacylglycerol_kin_accessory    Diacylglycerol_kinase_cat_dom    NAD/diacylglycerol_kinase_sf    PE/DAG-bd    PH-like_dom_sf    PH_domain    SAM    SAM/pointed_sf   
Domain families : Pfam (Sanger)C1_1 (PF00130)    DAGK_acc (PF00609)    DAGK_cat (PF00781)    PH (PF00169)    SAM_2 (PF07647)   
Domain families : Pfam (NCBI)pfam00130    pfam00609    pfam00781    pfam00169    pfam07647   
Domain families : Smart (EMBL)C1 (SM00109)  DAGKa (SM00045)  DAGKc (SM00046)  PH (SM00233)  SAM (SM00454)  
Conserved Domain (NCBI)DGKD
Blocks (Seattle)DGKD
PDB (RSDB)1R79    3BQ7   
PDB Europe1R79    3BQ7   
PDB (PDBSum)1R79    3BQ7   
PDB (IMB)1R79    3BQ7   
Structural Biology KnowledgeBase1R79    3BQ7   
SCOP (Structural Classification of Proteins)1R79    3BQ7   
CATH (Classification of proteins structures)1R79    3BQ7   
SuperfamilyQ16760
Human Protein Atlas [tissue]ENSG00000077044-DGKD [tissue]
Peptide AtlasQ16760
HPRD03492
IPIIPI00303136   IPI00374804   IPI00442567   IPI00979443   IPI00852951   IPI00917740   IPI00917242   
Protein Interaction databases
DIP (DOE-UCLA)Q16760
IntAct (EBI)Q16760
BioGRIDDGKD
STRING (EMBL)DGKD
ZODIACDGKD
Ontologies - Pathways
QuickGOQ16760
Ontology : AmiGONAD+ kinase activity  diacylglycerol kinase activity  diacylglycerol kinase activity  diacylglycerol kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  plasma membrane  plasma membrane  endocytosis  signal transduction  epidermal growth factor receptor signaling pathway  protein kinase C-activating G protein-coupled receptor signaling pathway  multicellular organism development  response to organic substance  protein transport  kinase binding  second-messenger-mediated signaling  diacylglycerol binding  platelet activation  intracellular signal transduction  identical protein binding  protein homodimerization activity  diacylglycerol metabolic process  diacylglycerol metabolic process  diacylglycerol metabolic process  glycerolipid metabolic process  lipid phosphorylation  lipid phosphorylation  metal ion binding  protein heterodimerization activity  
Ontology : EGO-EBINAD+ kinase activity  diacylglycerol kinase activity  diacylglycerol kinase activity  diacylglycerol kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  plasma membrane  plasma membrane  endocytosis  signal transduction  epidermal growth factor receptor signaling pathway  protein kinase C-activating G protein-coupled receptor signaling pathway  multicellular organism development  response to organic substance  protein transport  kinase binding  second-messenger-mediated signaling  diacylglycerol binding  platelet activation  intracellular signal transduction  identical protein binding  protein homodimerization activity  diacylglycerol metabolic process  diacylglycerol metabolic process  diacylglycerol metabolic process  glycerolipid metabolic process  lipid phosphorylation  lipid phosphorylation  metal ion binding  protein heterodimerization activity  
Pathways : KEGGGlycerolipid metabolism    Glycerophospholipid metabolism    Phosphatidylinositol signaling system   
NDEx NetworkDGKD
Atlas of Cancer Signalling NetworkDGKD
Wikipedia pathwaysDGKD
Orthology - Evolution
OrthoDB8527
GeneTree (enSembl)ENSG00000077044
Phylogenetic Trees/Animal Genes : TreeFamDGKD
HOGENOMQ16760
Homologs : HomoloGeneDGKD
Homology/Alignments : Family Browser (UCSC)DGKD
Gene fusions - Rearrangements
Fusion : MitelmanCDKN2B/DGKD [9p21.3/2q37.1]  
Fusion : MitelmanDGKD/ATG16L1 [2q37.1/2q37.1]  
Fusion : MitelmanDGKD/SAG [2q37.1/2q37.1]  
Fusion : MitelmanDGKD/SP140 [2q37.1/2q37.1]  
Fusion : MitelmanDGKD/SPP2 [2q37.1/2q37.1]  
Fusion PortalCDKN2B 9p21.3 DGKD 2q37.1 GBM
Fusion PortalDGKD 2q37.1 ATG16L1 2q37.1 LUSC
Fusion PortalDGKD 2q37.1 SAG 2q37.1 LUAD
Fusion PortalDGKD 2q37.1 SP140 2q37.1 BRCA
Fusion : QuiverDGKD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDGKD [hg38]
dbVarDGKD
ClinVarDGKD
MonarchDGKD
1000_GenomesDGKD 
Exome Variant ServerDGKD
GNOMAD BrowserENSG00000077044
Varsome BrowserDGKD
Genomic Variants (DGV)DGKD [DGVbeta]
DECIPHERDGKD [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDGKD 
Mutations
ICGC Data PortalDGKD 
TCGA Data PortalDGKD 
Broad Tumor PortalDGKD
OASIS PortalDGKD [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDGKD  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDGKD
Mutations and Diseases : HGMDDGKD
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DGKD
DgiDB (Drug Gene Interaction Database)DGKD
DoCM (Curated mutations)DGKD (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DGKD (select a term)
intoGenDGKD
Cancer3DDGKD(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601826   
Orphanet
DisGeNETDGKD
MedgenDGKD
Genetic Testing Registry DGKD
NextProtQ16760 [Medical]
GENETestsDGKD
Target ValidationDGKD
Huge Navigator DGKD [HugePedia]
ClinGenDGKD
Clinical trials, drugs, therapy
MyCancerGenomeDGKD
Protein Interactions : CTD
Pharm GKB GenePA27312
PharosQ16760
Clinical trialDGKD
Miscellaneous
canSAR (ICR)DGKD (select the gene name)
HarmonizomeDGKD
DataMed IndexDGKD
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDGKD
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:12:50 CET 2021
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