DGKH (diacylglycerol kinase eta)

2014-11-01 Affiliation

Identity

HGNC

DGKH

LOCATION

13q14.11

LOCUSID

160851

ALIAS

DGKeta

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 160851
MIM: 604071
HGNC: 2854
Ensembl: ENSG00000102780

Variants:

dbSNP: 160851
ClinVar: 160851
TCGA: ENSG00000102780
COSMIC: DGKH

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000102780	ENST00000261491	Q86XP1
ENSG00000102780	ENST00000337343	Q86XP1
ENSG00000102780	ENST00000379274	Q86XP1
ENSG00000102780	ENST00000536612	Q86XP1
ENSG00000102780	ENST00000611224	A0A087WZ02
ENSG00000102780	ENST00000626247	A0A0D9SF65
ENSG00000102780	ENST00000627777	A0A0D9SFR6
ENSG00000102780	ENST00000628433	Q86XP1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glycerolipid metabolism	KEGG	ko00561
Glycerophospholipid metabolism	KEGG	ko00564
Phosphatidylinositol signaling system	KEGG	ko04070
Glycerolipid metabolism	KEGG	hsa00561
Glycerophospholipid metabolism	KEGG	hsa00564
Phosphatidylinositol signaling system	KEGG	hsa04070
Metabolic pathways	KEGG	hsa01100
Choline metabolism in cancer	KEGG	hsa05231
Choline metabolism in cancer	KEGG	ko05231
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Effects of PIP2 hydrolysis	REACTOME	R-HSA-114508
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
17486107	2008	A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder.	242
17486107	2008	A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder.	242
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
21654738	2011	Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD.	32
19308021	2009	Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.	29
12810723	2003	Identification and characterization of two splice variants of human diacylglycerol kinase eta.	28
19710016	2009	Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization.	21
20733578	2011	Common SNPs and haplotypes in DGKH are associated with bipolar disorder and schizophrenia in the Chinese Han population.	19
20733578	2011	Common SNPs and haplotypes in DGKH are associated with bipolar disorder and schizophrenia in the Chinese Han population.	19
20519059	2010	Increased gene expression of diacylglycerol kinase η in bipolar disorder.	14

Citation

Dessen P

DGKH (diacylglycerol kinase eta)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62456/dgkh