DHRS4 (dehydrogenase/reductase 4)

2007-05-01  

Identity

HGNC
LOCATION
14q11.2
LOCUSID
ALIAS
CR,NRDR,PHCR,PSCD,SCAD-SRL,SDR-SRL,SDR25C1,SDR25C2
FUSION GENES

Other Information

Locus ID:

NCBI: 10901
MIM: 611596
HGNC: 16985
Ensembl: ENSG00000157326

Variants:

dbSNP: 10901
ClinVar: 10901
TCGA: ENSG00000157326
COSMIC: DHRS4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157326ENST00000313250Q9BTZ2
ENSG00000157326ENST00000397074Q9BTZ2
ENSG00000157326ENST00000397075Q9BTZ2
ENSG00000157326ENST00000543741F5GWZ1
ENSG00000157326ENST00000558263Q9BTZ2
ENSG00000157326ENST00000558581Q9BTZ2
ENSG00000157326ENST00000559632Q9BTZ2
ENSG00000157326ENST00000559975H0YNP7

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Retinol metabolismKEGGko00830
Retinol metabolismKEGGhsa00830
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Metabolic pathwaysKEGGhsa01100
Signal TransductionREACTOMER-HSA-162582
Signaling by Retinoic AcidREACTOMER-HSA-5362517
RA biosynthesis pathwayREACTOMER-HSA-5365859

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
228913342012AS1DHRS4, a head-to-head natural antisense transcript, silences the DHRS4 gene cluster in cis and trans.39
268649442016Enhancer RNA-driven looping enhances the transcription of the long noncoding RNA DHRS4-AS1, a controller of the DHRS4 gene cluster.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
185714932008Characterization of human DHRS4: an inducible short-chain dehydrogenase/reductase enzyme with 3beta-hydroxysteroid dehydrogenase activity.12
230367052012Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes.9
230367052012Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes.9
187547582009Alternative transcription initiation and splicing variants of the DHRS4 gene cluster.5
172305272007Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma.4
205252262010Bioinformatic analysis of the human DHRS4 gene cluster and a proposed mechanism for its transcriptional regulation.2
273231172016CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription.2

Citation

Dessen P

DHRS4 (dehydrogenase/reductase 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-05-01

Online version: http://atlasgeneticsoncology.org/gene/47526/dhrs4