Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DHX15 (DEAH-box helicase 15)

Identity

Alias_namesDDX15
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15
DEAH (Asp-Glu-Ala-His) box polypeptide 15
DEAH (Asp-Glu-Ala-His) box helicase 15
Alias_symbol (synonym)HRH2
DBP1
PRP43
PrPp43p
PRPF43
Other alias
HGNC (Hugo) DHX15
LocusID (NCBI) 1665
Atlas_Id 57193
Location 4p15.2  [Link to chromosome band 4p15]
Location_base_pair Starts at 24527465 and ends at 24584561 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DHX15 (4p15.2) / RBPJ (4p15.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  DHX15/RBPJ (4p15)

External links

Nomenclature
HGNC (Hugo)DHX15   2738
Cards
Entrez_Gene (NCBI)DHX15  1665  DEAH-box helicase 15
AliasesDBP1; DDX15; HRH2; PRP43; 
PRPF43; PrPp43p
GeneCards (Weizmann)DHX15
Ensembl hg19 (Hinxton)ENSG00000109606 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000109606 [Gene_View]  ENSG00000109606 [Sequence]  chr4:24527465-24584561 [Contig_View]  DHX15 [Vega]
ICGC DataPortalENSG00000109606
TCGA cBioPortalDHX15
AceView (NCBI)DHX15
Genatlas (Paris)DHX15
WikiGenes1665
SOURCE (Princeton)DHX15
Genetics Home Reference (NIH)DHX15
Genomic and cartography
GoldenPath hg38 (UCSC)DHX15  -     chr4:24527465-24584561 -  4p15.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DHX15  -     4p15.2   [Description]    (hg19-Feb_2009)
GoldenPathDHX15 - 4p15.2 [CytoView hg19]  DHX15 - 4p15.2 [CytoView hg38]
ImmunoBaseENSG00000109606
Mapping of homologs : NCBIDHX15 [Mapview hg19]  DHX15 [Mapview hg38]
OMIM603403   
Gene and transcription
Genbank (Entrez)AA771922 AB001636 AF279891 AK054614 AK055898
RefSeq transcript (Entrez)NM_001358
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DHX15
Cluster EST : UnigeneHs.696074 [ NCBI ]
CGAP (NCI)Hs.696074
Alternative Splicing GalleryENSG00000109606
Gene ExpressionDHX15 [ NCBI-GEO ]   DHX15 [ EBI - ARRAY_EXPRESS ]   DHX15 [ SEEK ]   DHX15 [ MEM ]
Gene Expression Viewer (FireBrowse)DHX15 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1665
GTEX Portal (Tissue expression)DHX15
Human Protein AtlasENSG00000109606-DHX15 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43143   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43143  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43143
Splice isoforms : SwissVarO43143
PhosPhoSitePlusO43143
Domaine pattern : Prosite (Expaxy)DEAH_ATP_HELICASE (PS00690)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    DNA/RNA_helicase_DEAH_CS    DUF1605    Helicase-assoc_dom    Helicase_ATP-bd    Helicase_C    P-loop_NTPase   
Domain families : Pfam (Sanger)DEAD (PF00270)    HA2 (PF04408)    Helicase_C (PF00271)    OB_NTP_bind (PF07717)   
Domain families : Pfam (NCBI)pfam00270    pfam04408    pfam00271    pfam07717   
Domain families : Smart (EMBL)DEXDc (SM00487)  HA2 (SM00847)  HELICc (SM00490)  
Conserved Domain (NCBI)DHX15
DMDM Disease mutations1665
Blocks (Seattle)DHX15
PDB (RSDB)5XDR   
PDB Europe5XDR   
PDB (PDBSum)5XDR   
PDB (IMB)5XDR   
Structural Biology KnowledgeBase5XDR   
SCOP (Structural Classification of Proteins)5XDR   
CATH (Classification of proteins structures)5XDR   
SuperfamilyO43143
Human Protein Atlas [tissue]ENSG00000109606-DHX15 [tissue]
Peptide AtlasO43143
IPIIPI00396435   IPI01015591   
Protein Interaction databases
DIP (DOE-UCLA)O43143
IntAct (EBI)O43143
FunCoupENSG00000109606
BioGRIDDHX15
STRING (EMBL)DHX15
ZODIACDHX15
Ontologies - Pathways
QuickGOO43143
Ontology : AmiGOmRNA splicing, via spliceosome  RNA binding  RNA binding  RNA helicase activity  double-stranded RNA binding  protein binding  ATP binding  nucleus  nucleoplasm  U12-type spliceosomal complex  nucleolus  mRNA processing  RNA splicing  response to toxic substance  nuclear speck  3'-5' RNA helicase activity  response to alkaloid  U2-type post-mRNA release spliceosomal complex  
Ontology : EGO-EBImRNA splicing, via spliceosome  RNA binding  RNA binding  RNA helicase activity  double-stranded RNA binding  protein binding  ATP binding  nucleus  nucleoplasm  U12-type spliceosomal complex  nucleolus  mRNA processing  RNA splicing  response to toxic substance  nuclear speck  3'-5' RNA helicase activity  response to alkaloid  U2-type post-mRNA release spliceosomal complex  
Pathways : KEGGSpliceosome   
NDEx NetworkDHX15
Atlas of Cancer Signalling NetworkDHX15
Wikipedia pathwaysDHX15
Orthology - Evolution
OrthoDB1665
GeneTree (enSembl)ENSG00000109606
Phylogenetic Trees/Animal Genes : TreeFamDHX15
HOGENOMO43143
Homologs : HomoloGeneDHX15
Homology/Alignments : Family Browser (UCSC)DHX15
Gene fusions - Rearrangements
Fusion : QuiverDHX15
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDHX15 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DHX15
dbVarDHX15
ClinVarDHX15
1000_GenomesDHX15 
Exome Variant ServerDHX15
ExAC (Exome Aggregation Consortium)ENSG00000109606
GNOMAD BrowserENSG00000109606
Varsome BrowserDHX15
Genetic variants : HAPMAP1665
Genomic Variants (DGV)DHX15 [DGVbeta]
DECIPHERDHX15 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDHX15 
Mutations
ICGC Data PortalDHX15 
TCGA Data PortalDHX15 
Broad Tumor PortalDHX15
OASIS PortalDHX15 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDHX15  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDHX15
Mutations and Diseases : HGMDDHX15
BioMutasearch DHX15
DgiDB (Drug Gene Interaction Database)DHX15
DoCM (Curated mutations)DHX15 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DHX15 (select a term)
intoGenDHX15
Cancer3DDHX15(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603403   
Orphanet
DisGeNETDHX15
MedgenDHX15
Genetic Testing Registry DHX15
NextProtO43143 [Medical]
TSGene1665
GENETestsDHX15
Target ValidationDHX15
Huge Navigator DHX15 [HugePedia]
snp3D : Map Gene to Disease1665
BioCentury BCIQDHX15
ClinGenDHX15
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1665
Chemical/Pharm GKB GenePA27204
Clinical trialDHX15
Miscellaneous
canSAR (ICR)DHX15 (select the gene name)
DataMed IndexDHX15
Probes
Litterature
PubMed123 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDHX15
EVEXDHX15
GoPubMedDHX15
iHOPDHX15
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:40:20 CET 2019
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