DHX33 (DEAH-box helicase 33)

2007-04-01  

Identity

HGNC
LOCATION
17p13.2
LOCUSID
ALIAS
DDX33
FUSION GENES

Other Information

Locus ID:

NCBI: 56919
MIM: 614405
HGNC: 16718
Ensembl: ENSG00000005100

Variants:

dbSNP: 56919
ClinVar: 56919
TCGA: ENSG00000005100
COSMIC: DHX33

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000005100ENST00000225296Q9H6R0
ENSG00000005100ENST00000433302Q05BE5
ENSG00000005100ENST00000572490I3L1L6
ENSG00000005100ENST00000574023I3L0M5

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
238712092013The DHX33 RNA helicase senses cytosolic RNA and activates the NLRP3 inflammasome.61
219307792011Identification of DHX33 as a mediator of rRNA synthesis and cell growth.21
194235402009Common variation in genes related to innate immunity and risk of adult glioma.19
204069642010Risk of meningioma and common variation in genes related to innate immunity.12
276930402016miR-634 exhibits anti-tumor activities toward hepatocellular carcinoma via Rab1A and DHX33.11
261000192015The DHX33 RNA Helicase Promotes mRNA Translation Initiation.9
234018542013P19ARF and RasV¹² offer opposing regulation of DHX33 translation to dictate tumor cell fate.8
204387852010Polymorphisms in innate immunity genes and risk of childhood leukemia.5
276015872016DHX33 Transcriptionally Controls Genes Involved in the Cell Cycle.4
305529902019The RNA helicase DHX33 is required for cancer cell proliferation in human glioblastoma and confers resistance to PI3K/mTOR inhibition.4

Citation

Dessen P

DHX33 (DEAH-box helicase 33)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47060/dhx33