DHX58 (DExH-box helicase 58)

2003-02-01  

Identity

HGNC
LOCATION
17q21.2
LOCUSID
ALIAS
D11LGP2,D11lgp2e,LGP2,RLR-3
FUSION GENES

Other Information

Locus ID:

NCBI: 79132
MIM: 608588
HGNC: 29517
Ensembl: ENSG00000108771

Variants:

dbSNP: 79132
ClinVar: 79132
TCGA: ENSG00000108771
COSMIC: DHX58

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108771ENST00000251642Q96C10
ENSG00000108771ENST00000251642A0A024R1Y5
ENSG00000108771ENST00000413196C9JG98
ENSG00000108771ENST00000430773C9JE76
ENSG00000108771ENST00000589979K7EPP0
ENSG00000108771ENST00000591220K7EMZ5

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
161161712005Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity.546
170209502006RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2.111
212854122011Mitochondrial membrane potential is required for MAVS-mediated antiviral signaling.87
251275122014The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly.82
192789962009The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA.64
194036702009A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2.61
223011342012Paramyxovirus V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-dependent interferon induction.61
245502532014Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells.51
231849512013ATP hydrolysis enhances RNA recognition and antiviral signal transduction by the innate immune sensor, laboratory of genetics and physiology 2 (LGP2).40
236717102013LGP2 plays a critical role in sensitizing mda-5 to activation by double-stranded RNA.39

Citation

Dessen P

DHX58 (DExH-box helicase 58)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41150/dhx58