Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DKKL1 (dickkopf like acrosomal protein 1)

Identity

Alias_namesdickkopf-like 1
Alias_symbol (synonym)SGY-1
CT34
Other aliasSGY
SGY1
HGNC (Hugo) DKKL1
LocusID (NCBI) 27120
Atlas_Id 56779
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 49363785 and ends at 49375116 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EEF1A2 (20q13.33) / DKKL1 (19q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(19;20)(q13;q13) EEF1A2/DKKL1

External links

Nomenclature
HGNC (Hugo)DKKL1   16528
Cards
Entrez_Gene (NCBI)DKKL1  27120  dickkopf like acrosomal protein 1
AliasesCT34; SGY; SGY-1; SGY1
GeneCards (Weizmann)DKKL1
Ensembl hg19 (Hinxton)ENSG00000104901 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104901 [Gene_View]  ENSG00000104901 [Sequence]  chr19:49363785-49375116 [Contig_View]  DKKL1 [Vega]
ICGC DataPortalENSG00000104901
TCGA cBioPortalDKKL1
AceView (NCBI)DKKL1
Genatlas (Paris)DKKL1
WikiGenes27120
SOURCE (Princeton)DKKL1
Genetics Home Reference (NIH)DKKL1
Genomic and cartography
GoldenPath hg38 (UCSC)DKKL1  -     chr19:49363785-49375116 +  19q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DKKL1  -     19q13.33   [Description]    (hg19-Feb_2009)
GoldenPathDKKL1 - 19q13.33 [CytoView hg19]  DKKL1 - 19q13.33 [CytoView hg38]
ImmunoBaseENSG00000104901
Mapping of homologs : NCBIDKKL1 [Mapview hg19]  DKKL1 [Mapview hg38]
OMIM605418   
Gene and transcription
Genbank (Entrez)AF177398 AI879324 AY358922 BC030581 BI826695
RefSeq transcript (Entrez)NM_001197301 NM_001197302 NM_014419
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DKKL1
Cluster EST : UnigeneHs.515855 [ NCBI ]
CGAP (NCI)Hs.515855
Alternative Splicing GalleryENSG00000104901
Gene ExpressionDKKL1 [ NCBI-GEO ]   DKKL1 [ EBI - ARRAY_EXPRESS ]   DKKL1 [ SEEK ]   DKKL1 [ MEM ]
Gene Expression Viewer (FireBrowse)DKKL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27120
GTEX Portal (Tissue expression)DKKL1
Human Protein AtlasENSG00000104901-DKKL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UK85   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UK85  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UK85
Splice isoforms : SwissVarQ9UK85
PhosPhoSitePlusQ9UK85
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)DKKL1
DMDM Disease mutations27120
Blocks (Seattle)DKKL1
SuperfamilyQ9UK85
Human Protein Atlas [tissue]ENSG00000104901-DKKL1 [tissue]
Peptide AtlasQ9UK85
IPIIPI00007271   IPI00983069   IPI00983776   
Protein Interaction databases
DIP (DOE-UCLA)Q9UK85
IntAct (EBI)Q9UK85
FunCoupENSG00000104901
BioGRIDDKKL1
STRING (EMBL)DKKL1
ZODIACDKKL1
Ontologies - Pathways
QuickGOQ9UK85
Ontology : AmiGOacrosomal vesicle  extracellular space  penetration of zona pellucida  anatomical structure morphogenesis  co-receptor binding  positive regulation of apoptotic process  positive regulation of fat cell differentiation  receptor antagonist activity  negative regulation of canonical Wnt signaling pathway  negative regulation of testosterone biosynthetic process  negative regulation of signaling receptor activity  
Ontology : EGO-EBIacrosomal vesicle  extracellular space  penetration of zona pellucida  anatomical structure morphogenesis  co-receptor binding  positive regulation of apoptotic process  positive regulation of fat cell differentiation  receptor antagonist activity  negative regulation of canonical Wnt signaling pathway  negative regulation of testosterone biosynthetic process  negative regulation of signaling receptor activity  
NDEx NetworkDKKL1
Atlas of Cancer Signalling NetworkDKKL1
Wikipedia pathwaysDKKL1
Orthology - Evolution
OrthoDB27120
GeneTree (enSembl)ENSG00000104901
Phylogenetic Trees/Animal Genes : TreeFamDKKL1
HOGENOMQ9UK85
Homologs : HomoloGeneDKKL1
Homology/Alignments : Family Browser (UCSC)DKKL1
Gene fusions - Rearrangements
Fusion : QuiverDKKL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDKKL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DKKL1
dbVarDKKL1
ClinVarDKKL1
1000_GenomesDKKL1 
Exome Variant ServerDKKL1
ExAC (Exome Aggregation Consortium)ENSG00000104901
GNOMAD BrowserENSG00000104901
Varsome BrowserDKKL1
Genetic variants : HAPMAP27120
Genomic Variants (DGV)DKKL1 [DGVbeta]
DECIPHERDKKL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDKKL1 
Mutations
ICGC Data PortalDKKL1 
TCGA Data PortalDKKL1 
Broad Tumor PortalDKKL1
OASIS PortalDKKL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDKKL1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDKKL1
Mutations and Diseases : HGMDDKKL1
BioMutasearch DKKL1
DgiDB (Drug Gene Interaction Database)DKKL1
DoCM (Curated mutations)DKKL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DKKL1 (select a term)
intoGenDKKL1
Cancer3DDKKL1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605418   
Orphanet
DisGeNETDKKL1
MedgenDKKL1
Genetic Testing Registry DKKL1
NextProtQ9UK85 [Medical]
TSGene27120
GENETestsDKKL1
Target ValidationDKKL1
Huge Navigator DKKL1 [HugePedia]
snp3D : Map Gene to Disease27120
BioCentury BCIQDKKL1
ClinGenDKKL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27120
Chemical/Pharm GKB GenePA134974559
Clinical trialDKKL1
Miscellaneous
canSAR (ICR)DKKL1 (select the gene name)
DataMed IndexDKKL1
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDKKL1
EVEXDKKL1
GoPubMedDKKL1
iHOPDKKL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:40:28 CET 2019
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