DLEC1 (DLEC1 cilia and flagella associated protein)

2003-02-01  

Identity

HGNC
LOCATION
3p22.2
LOCUSID
ALIAS
CFAP81,DLC-1,DLC1,F56,FAP81
FUSION GENES

Other Information

Locus ID:

NCBI: 9940
MIM: 604050
HGNC: 2899
Ensembl: ENSG00000008226

Variants:

dbSNP: 9940
ClinVar: 9940
TCGA: ENSG00000008226
COSMIC: DLEC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000008226ENST00000308059Q9Y238
ENSG00000008226ENST00000346219Q9Y238
ENSG00000008226ENST00000447130Q32W76

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
185945352008DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma.38
167567192006Candidate tumor-suppressor gene DLEC1 is frequently downregulated by promoter hypermethylation and histone hypoacetylation in human epithelial ovarian cancer.30
191561372009DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancers.25
193392702009Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.24
170998702007Epigenetic inactivation of the deleted in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma.18
206390482010Aberrant promoter methylation of DLEC1, a critical 3p22 tumor suppressor for renal cell carcinoma, is associated with more advanced tumor stage.18
181912692008The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle.17
230505862012Epigenetic silencing of the 3p22 tumor suppressor DLEC1 by promoter CpG methylation in non-Hodgkin and Hodgkin lymphomas.11
206308292010Frequent epigenetic inactivation of deleted in lung and esophageal cancer 1 gene by promoter methylation in non-small-cell lung cancer.9

Citation

Dessen P

DLEC1 (DLEC1 cilia and flagella associated protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40329/dlec1