DLK1 (delta like non-canonical Notch ligand 1)

2007-02-01  

Identity

HGNC
DLK1
LOCATION
14q32.2
LOCUSID
8788
ALIAS
DLK,DLK-1,Delta1,FA1,PREF1,Pref-1,ZOG,pG2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8788
MIM: 176290
HGNC: 2907
Ensembl: ENSG00000185559

Variants:

dbSNP: 8788
ClinVar: 8788
TCGA: ENSG00000185559
COSMIC: DLK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185559ENST00000331224P80370
ENSG00000185559ENST00000341267P80370
ENSG00000185559ENST00000392848G3XAH5
ENSG00000185559ENST00000556051G3V2R7

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
Activated NOTCH1 Transmits Signal to the NucleusREACTOMER-HSA-2122948

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199668052010The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes.112
199668052010The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes.112
243742172014Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets.97
228256602013The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis.87
195417432009Minireview: Pref-1: role in adipogenesis and mesenchymal cell fate.77
110768562000Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation.69
217374522011DLK1-DIO3 genomic imprinted microRNA cluster at 14q32.2 defines a stemlike subtype of hepatocellular carcinoma associated with poor survival.57
199343102009Hypoxia-regulated delta-like 1 homologue enhances cancer cell stemness and tumorigenicity.50
186285272008Selective loss of MEG3 expression and intergenic differentially methylated region hypermethylation in the MEG3/DLK1 locus in human clinically nonfunctioning pituitary adenomas.48
225081852012Marrow fat and preadipocyte factor-1 levels decrease with recovery in women with anorexia nervosa.47

Citation

Dessen P

DLK1 (delta like non-canonical Notch ligand 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46393/dlk1