DLL3 (delta like canonical Notch ligand 3)

2007-04-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
SCDO1
FUSION GENES

Other Information

Locus ID:

NCBI: 10683
MIM: 602768
HGNC: 2909
Ensembl: ENSG00000090932

Variants:

dbSNP: 10683
ClinVar: 10683
TCGA: ENSG00000090932
COSMIC: DLL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090932ENST00000205143Q9NYJ7
ENSG00000090932ENST00000596614M0R177

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Notch signaling pathwayKEGGko04330
Notch signaling pathwayKEGGhsa04330
Notch signalingKEGGhsa_M00682
Notch signalingKEGGM00682
Endocrine resistanceKEGGko01522
Endocrine resistanceKEGGhsa01522
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658

References

Pubmed IDYearTitleCitations
349314562022ASCL1 and DLL3 expressions and their clinicopathological implications in surgically resected pure small cell lung cancer: A study of 247 cases from the National Cancer Center of China.3
359839512022DLL3 as an Emerging Target for the Treatment of Neuroendocrine Neoplasms.18
349314562022ASCL1 and DLL3 expressions and their clinicopathological implications in surgically resected pure small cell lung cancer: A study of 247 cases from the National Cancer Center of China.3
359839512022DLL3 as an Emerging Target for the Treatment of Neuroendocrine Neoplasms.18
330311012021TTF-1 and c-MYC-defined Phenotypes of Large Cell Neuroendocrine Carcinoma and Delta-like Protein 3 Expression for Treatment Selection.2
334098122021Diagnostic and Predictive Role of DLL3 Expression in Gastroenteropancreatic Neuroendocrine Neoplasms.12
341071322021Delta-like canonical Notch ligand 3 as a potential therapeutic target in malignancies: A brief overview.11
341845662021Investigation of Candidate Genes and Pathways in Basal/TNBC Patients by Integrated Analysis.6
330311012021TTF-1 and c-MYC-defined Phenotypes of Large Cell Neuroendocrine Carcinoma and Delta-like Protein 3 Expression for Treatment Selection.2
334098122021Diagnostic and Predictive Role of DLL3 Expression in Gastroenteropancreatic Neuroendocrine Neoplasms.12
341071322021Delta-like canonical Notch ligand 3 as a potential therapeutic target in malignancies: A brief overview.11
341845662021Investigation of Candidate Genes and Pathways in Basal/TNBC Patients by Integrated Analysis.6
325545162020A Bispecific DLL3/CD3 IgG-Like T-Cell Engaging Antibody Induces Antitumor Responses in Small Cell Lung Cancer.32
326919822020DLL3 expression is a predictive marker of sensitivity to adjuvant chemotherapy for pulmonary LCNEC.10
325545162020A Bispecific DLL3/CD3 IgG-Like T-Cell Engaging Antibody Induces Antitumor Responses in Small Cell Lung Cancer.32

Citation

Dessen P

DLL3 (delta like canonical Notch ligand 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47257/dll3