DLX3 (distal-less homeobox 3)

2007-09-01  

Identity

HGNC
DLX3
LOCATION
17q21.33
LOCUSID
1747
ALIAS
AI4,TDO

Other Information

Locus ID:

NCBI: 1747
MIM: 600525
HGNC: 2916
Ensembl: ENSG00000064195

Variants:

dbSNP: 1747
ClinVar: 1747
TCGA: ENSG00000064195
COSMIC: DLX3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000064195ENST00000434704O60479
ENSG00000064195ENST00000512495F8VXG1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
156662992005DLX3 mutation associated with autosomal dominant amelogenesis imperfecta with taurodontism.38
117928342002Genomic structure and functional control of the Dlx3-7 bigene cluster.26
184926702008Molecular consequences of a frameshifted DLX3 mutant leading to Tricho-Dento-Osseous syndrome.24
192826652009Homeodomain protein Dlx3 induces phosphorylation-dependent p63 degradation.22
189786782008Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.21
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
162475492006PAX9 and TGFB3 are linked to susceptibility to nonsyndromic cleft lip with or without cleft palate in the Japanese: population-based and family-based candidate gene analyses.17
182031972008DLX3 c.561_562delCT mutation causes attenuated phenotype of tricho-dento-osseous syndrome.15
164679782006Gene expression of runx2, Osterix, c-fos, DLX-3, DLX-5, and MSX-2 in dental follicle cells during osteogenic differentiation in vitro.14
154541072004Increased bone density associated with DLX3 mutation in the tricho-dento-osseous syndrome.13

Citation

Dessen P

DLX3 (distal-less homeobox 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-09-01

Online version: http://atlasgeneticsoncology.org/gene/49723/dlx3