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DMC1 (DNA meiotic recombinase 1)

Identity

Alias (NCBI)DMC1H
LIM15
dJ199H16.1
HGNC (Hugo) DMC1
HGNC Alias symbLIM15
HGNC Previous nameDMC1 (dosage suppressor of mck1, yeast homolog) meiosis-specific homologous recombination
 DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)
LocusID (NCBI) 11144
Atlas_Id 40337
Location 22q13.1  [Link to chromosome band 22q13]
Location_base_pair Starts at 38518948 and ends at 38570183 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DMC1 (22q13.1) / DNAL4 (22q13.1)DMC1 22q13.1 / DNAL4 22q13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  DMC1/DNAL4 (22q13)


External links

Nomenclature
HGNC (Hugo)DMC1   2927
Cards
Entrez_Gene (NCBI)DMC1  11144  DNA meiotic recombinase 1
AliasesDMC1H; LIM15; dJ199H16.1
GeneCards (Weizmann)DMC1
Ensembl hg19 (Hinxton)ENSG00000100206 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100206 [Gene_View]  ENSG00000100206 [Sequence]  chr22:38518948-38570183 [Contig_View]  DMC1 [Vega]
ICGC DataPortalENSG00000100206
TCGA cBioPortalDMC1
AceView (NCBI)DMC1
Genatlas (Paris)DMC1
WikiGenes11144
SOURCE (Princeton)DMC1
Genetics Home Reference (NIH)DMC1
Genomic and cartography
GoldenPath hg38 (UCSC)DMC1  -     chr22:38518948-38570183 -  22q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DMC1  -     22q13.1   [Description]    (hg19-Feb_2009)
GoldenPathDMC1 - 22q13.1 [CytoView hg19]  DMC1 - 22q13.1 [CytoView hg38]
ImmunoBaseENSG00000100206
genome Data Viewer NCBIDMC1 [Mapview hg19]  
OMIM602721   
Gene and transcription
Genbank (Entrez)AK292617 AK297664 BC035658 BC125163 BC125164
RefSeq transcript (Entrez)NM_001278208 NM_001363017 NM_007068
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DMC1
Alternative Splicing GalleryENSG00000100206
Gene ExpressionDMC1 [ NCBI-GEO ]   DMC1 [ EBI - ARRAY_EXPRESS ]   DMC1 [ SEEK ]   DMC1 [ MEM ]
Gene Expression Viewer (FireBrowse)DMC1 [ Firebrowse - Broad ]
GenevisibleExpression of DMC1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11144
GTEX Portal (Tissue expression)DMC1
Human Protein AtlasENSG00000100206-DMC1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14565   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14565  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14565
Splice isoforms : SwissVarQ14565
PhosPhoSitePlusQ14565
Domaine pattern : Prosite (Expaxy)RECA_2 (PS50162)    RECA_3 (PS50163)   
Domains : Interpro (EBI)AAA+_ATPase    Dmc1    DNA_recomb/repair_Rad51_C    DNA_recomb/repair_RecA-like    DNA_repair_Rad51/TF_NusA_a-hlx    P-loop_NTPase    Rad51_DMC1_RadA    RecA_ATP-bd    RecA_monomer-monomer_interface   
Domain families : Pfam (Sanger)Rad51 (PF08423)   
Domain families : Pfam (NCBI)pfam08423   
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)DMC1
DMDM Disease mutations11144
Blocks (Seattle)DMC1
PDB (RSDB)1V5W    2ZJB    4HYY    6R3P   
PDB Europe1V5W    2ZJB    4HYY    6R3P   
PDB (PDBSum)1V5W    2ZJB    4HYY    6R3P   
PDB (IMB)1V5W    2ZJB    4HYY    6R3P   
Structural Biology KnowledgeBase1V5W    2ZJB    4HYY    6R3P   
SCOP (Structural Classification of Proteins)1V5W    2ZJB    4HYY    6R3P   
CATH (Classification of proteins structures)1V5W    2ZJB    4HYY    6R3P   
SuperfamilyQ14565
Human Protein Atlas [tissue]ENSG00000100206-DMC1 [tissue]
Peptide AtlasQ14565
HPRD04099
IPIIPI00031512   IPI00880171   IPI00880014   
Protein Interaction databases
DIP (DOE-UCLA)Q14565
IntAct (EBI)Q14565
FunCoupENSG00000100206
BioGRIDDMC1
STRING (EMBL)DMC1
ZODIACDMC1
Ontologies - Pathways
QuickGOQ14565
Ontology : AmiGOrecombinase activity  DNA recombinase assembly  chromosome, telomeric region  condensed nuclear chromosome  ovarian follicle development  oocyte maturation  DNA binding  double-stranded DNA binding  single-stranded DNA binding  protein binding  ATP binding  nucleus  chromosome  mitotic recombination  synapsis  reciprocal meiotic recombination  male meiosis I  spermatogenesis  spermatid development  female gamete generation  DNA-dependent ATPase activity  response to ionizing radiation  strand invasion  identical protein binding  meiotic cell cycle  chromosome organization involved in meiotic cell cycle  
Ontology : EGO-EBIrecombinase activity  DNA recombinase assembly  chromosome, telomeric region  condensed nuclear chromosome  ovarian follicle development  oocyte maturation  DNA binding  double-stranded DNA binding  single-stranded DNA binding  protein binding  ATP binding  nucleus  chromosome  mitotic recombination  synapsis  reciprocal meiotic recombination  male meiosis I  spermatogenesis  spermatid development  female gamete generation  DNA-dependent ATPase activity  response to ionizing radiation  strand invasion  identical protein binding  meiotic cell cycle  chromosome organization involved in meiotic cell cycle  
NDEx NetworkDMC1
Atlas of Cancer Signalling NetworkDMC1
Wikipedia pathwaysDMC1
Orthology - Evolution
OrthoDB11144
GeneTree (enSembl)ENSG00000100206
Phylogenetic Trees/Animal Genes : TreeFamDMC1
HOGENOMQ14565
Homologs : HomoloGeneDMC1
Homology/Alignments : Family Browser (UCSC)DMC1
Gene fusions - Rearrangements
Fusion : MitelmanDMC1/DNAL4 [22q13.1/22q13.1]  
Fusion PortalDMC1 22q13.1 DNAL4 22q13.1 BRCA
Fusion : QuiverDMC1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDMC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DMC1
dbVarDMC1
ClinVarDMC1
1000_GenomesDMC1 
Exome Variant ServerDMC1
GNOMAD BrowserENSG00000100206
Varsome BrowserDMC1
Genetic variants : HAPMAP11144
Genomic Variants (DGV)DMC1 [DGVbeta]
DECIPHERDMC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDMC1 
Mutations
ICGC Data PortalDMC1 
TCGA Data PortalDMC1 
Broad Tumor PortalDMC1
OASIS PortalDMC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDMC1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDMC1
Mutations and Diseases : HGMDDMC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DMC1
DgiDB (Drug Gene Interaction Database)DMC1
DoCM (Curated mutations)DMC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DMC1 (select a term)
intoGenDMC1
Cancer3DDMC1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602721   
Orphanet
DisGeNETDMC1
MedgenDMC1
Genetic Testing Registry DMC1
NextProtQ14565 [Medical]
TSGene11144
GENETestsDMC1
Target ValidationDMC1
Huge Navigator DMC1 [HugePedia]
snp3D : Map Gene to Disease11144
BioCentury BCIQDMC1
ClinGenDMC1
Clinical trials, drugs, therapy
Protein Interactions : CTD11144
Pharm GKB GenePA27377
Clinical trialDMC1
Miscellaneous
canSAR (ICR)DMC1 (select the gene name)
HarmonizomeDMC1
DataMed IndexDMC1
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDMC1
EVEXDMC1
GoPubMedDMC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 15:10:48 CEST 2020

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