DMP1 (dentin matrix acidic phosphoprotein 1)

2003-05-01  

Identity

HGNC
LOCATION
4q22.1
LOCUSID
ALIAS
ARHP,ARHR,DMP-1
FUSION GENES

Other Information

Locus ID:

NCBI: 1758
MIM: 600980
HGNC: 2932
Ensembl: ENSG00000152592

Variants:

dbSNP: 1758
ClinVar: 1758
TCGA: ENSG00000152592
COSMIC: DMP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152592ENST00000282479Q13316
ENSG00000152592ENST00000339673Q13316

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Extracellular matrix organizationREACTOMER-HSA-1474244
ECM proteoglycansREACTOMER-HSA-3000178

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
170336212006Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism.377
170336252006DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis.164
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
196792052009Patterns of FGF-23, DMP1, and MEPE expression in patients with chronic kidney disease.83
162942702005DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis.79
180376462007Dentin matrix protein 1 (DMP1): new and important roles for biomineralization and phosphate homeostasis.71
153293692004Expression of SIBLINGs and their partner MMPs in salivary glands.70
159549042005Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs).59
145783492004Bone morphogenetic protein-1/Tolloid-like proteinases process dentin matrix protein-1.57
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45

Citation

Dessen P

DMP1 (dentin matrix acidic phosphoprotein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40338/dmp1