Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1763
MIM: 601810
HGNC: 2939
Ensembl: ENSG00000138346
Variants:
dbSNP: 1763
ClinVar: 1763
TCGA: ENSG00000138346
COSMIC: DNA2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38331987 | 2024 | Targeting DNA2 overcomes metabolic reprogramming in multiple myeloma. | 0 |
| 38721777 | 2024 | EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells. | 0 |
| 38331987 | 2024 | Targeting DNA2 overcomes metabolic reprogramming in multiple myeloma. | 0 |
| 38721777 | 2024 | EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells. | 0 |
| 36916001 | 2023 | Estrogen upregulates DNA2 expression through the PI3K-AKT pathway in endometrial carcinoma. | 1 |
| 37526271 | 2023 | FANCD2 and RAD51 recombinase directly inhibit DNA2 nuclease at stalled replication forks and FANCD2 acts as a novel RAD51 mediator in strand exchange to promote genome stability. | 5 |
| 36916001 | 2023 | Estrogen upregulates DNA2 expression through the PI3K-AKT pathway in endometrial carcinoma. | 1 |
| 37526271 | 2023 | FANCD2 and RAD51 recombinase directly inhibit DNA2 nuclease at stalled replication forks and FANCD2 acts as a novel RAD51 mediator in strand exchange to promote genome stability. | 5 |
| 35300981 | 2022 | The nuclease activity of DNA2 promotes exonuclease 1-independent mismatch repair. | 5 |
| 35300981 | 2022 | The nuclease activity of DNA2 promotes exonuclease 1-independent mismatch repair. | 5 |
| 33574966 | 2021 | Increased Expression of DNA2 Was Linked to Poor Prognosis in Breast Cancer. | 4 |
| 34047877 | 2021 | Up-regulation of DNA2 results in cell proliferation and migration in endometriosis. | 1 |
| 33574966 | 2021 | Increased Expression of DNA2 Was Linked to Poor Prognosis in Breast Cancer. | 4 |
| 34047877 | 2021 | Up-regulation of DNA2 results in cell proliferation and migration in endometriosis. | 1 |
| 31754720 | 2020 | Multiple roles of DNA2 nuclease/helicase in DNA metabolism, genome stability and human diseases. | 46 |
Citation
Dessen P
DNA2 (DNA replication helicase/nuclease 2)
Atlas Genet Cytogenet Oncol Haematol. 2009-01-01
Online version: http://atlasgeneticsoncology.org/gene/50641/dna2
