Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DNAJA1 (DnaJ heat shock protein family (Hsp40) member A1)

Identity

Alias_namesHSJ2
DnaJ (Hsp40) homolog, subfamily A, member 1
Alias_symbol (synonym)HSPF4
hdj-2
dj-2
NEDD7
Other aliasDJ-2
DjA1
HDJ2
HSDJ
HSJ-2
hDJ-2
HGNC (Hugo) DNAJA1
LocusID (NCBI) 3301
Atlas_Id 40341
Location 9p21.1  [Link to chromosome band 9p21]
Location_base_pair Starts at 33025203 and ends at 33039907 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DNAJA1 (9p21.1) / GALNTL6 (4q34.1)DNAJA1 9p21.1 / GALNTL6 4q34.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(4;9)(q34;p21) DNAJA1/GALNTL6

External links

Nomenclature
HGNC (Hugo)DNAJA1   5229
Cards
Entrez_Gene (NCBI)DNAJA1  3301  DnaJ heat shock protein family (Hsp40) member A1
AliasesDJ-2; DjA1; HDJ2; HSDJ; 
HSJ-2; HSJ2; HSPF4; NEDD7; hDJ-2
GeneCards (Weizmann)DNAJA1
Ensembl hg19 (Hinxton)ENSG00000086061 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000086061 [Gene_View]  ENSG00000086061 [Sequence]  chr9:33025203-33039907 [Contig_View]  DNAJA1 [Vega]
ICGC DataPortalENSG00000086061
TCGA cBioPortalDNAJA1
AceView (NCBI)DNAJA1
Genatlas (Paris)DNAJA1
WikiGenes3301
SOURCE (Princeton)DNAJA1
Genetics Home Reference (NIH)DNAJA1
Genomic and cartography
GoldenPath hg38 (UCSC)DNAJA1  -     chr9:33025203-33039907 +  9p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DNAJA1  -     9p21.1   [Description]    (hg19-Feb_2009)
GoldenPathDNAJA1 - 9p21.1 [CytoView hg19]  DNAJA1 - 9p21.1 [CytoView hg38]
ImmunoBaseENSG00000086061
Mapping of homologs : NCBIDNAJA1 [Mapview hg19]  DNAJA1 [Mapview hg38]
OMIM602837   
Gene and transcription
Genbank (Entrez)AJ277242 AK095541 AK289623 AK298725 AY186741
RefSeq transcript (Entrez)NM_001314039 NM_001539
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DNAJA1
Cluster EST : UnigeneHs.707338 [ NCBI ]
CGAP (NCI)Hs.707338
Alternative Splicing GalleryENSG00000086061
Gene ExpressionDNAJA1 [ NCBI-GEO ]   DNAJA1 [ EBI - ARRAY_EXPRESS ]   DNAJA1 [ SEEK ]   DNAJA1 [ MEM ]
Gene Expression Viewer (FireBrowse)DNAJA1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3301
GTEX Portal (Tissue expression)DNAJA1
Human Protein AtlasENSG00000086061-DNAJA1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31689   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP31689  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP31689
Splice isoforms : SwissVarP31689
PhosPhoSitePlusP31689
Domaine pattern : Prosite (Expaxy)DNAJ_1 (PS00636)    DNAJ_2 (PS50076)    ZF_CR (PS51188)   
Domains : Interpro (EBI)DnaJ    DnaJ_C    DnaJ_domain    DnaJ_domain_CS    HSP40/DnaJ_pept-bd    HSP_DnaJ_Cys-rich_dom    HSP_DnaJ_Cys-rich_dom_sf    J_dom_sf   
Domain families : Pfam (Sanger)DnaJ (PF00226)    DnaJ_C (PF01556)    DnaJ_CXXCXGXG (PF00684)   
Domain families : Pfam (NCBI)pfam00226    pfam01556    pfam00684   
Domain families : Smart (EMBL)DnaJ (SM00271)  
Conserved Domain (NCBI)DNAJA1
DMDM Disease mutations3301
Blocks (Seattle)DNAJA1
PDB (RSDB)2LO1    2M6Y   
PDB Europe2LO1    2M6Y   
PDB (PDBSum)2LO1    2M6Y   
PDB (IMB)2LO1    2M6Y   
Structural Biology KnowledgeBase2LO1    2M6Y   
SCOP (Structural Classification of Proteins)2LO1    2M6Y   
CATH (Classification of proteins structures)2LO1    2M6Y   
SuperfamilyP31689
Human Protein Atlas [tissue]ENSG00000086061-DNAJA1 [tissue]
Peptide AtlasP31689
HPRD04159
IPIIPI00012535   IPI01019083   IPI01013215   
Protein Interaction databases
DIP (DOE-UCLA)P31689
IntAct (EBI)P31689
FunCoupENSG00000086061
BioGRIDDNAJA1
STRING (EMBL)DNAJA1
ZODIACDNAJA1
Ontologies - Pathways
QuickGOP31689
Ontology : AmiGOG protein-coupled receptor binding  ATPase activator activity  protein binding  ATP binding  nucleus  mitochondrion  cytosol  cytosol  cytosol  protein folding  response to unfolded protein  spermatogenesis  response to heat  microtubule cytoskeleton  membrane  membrane  flagellated sperm motility  androgen receptor signaling pathway  Hsp70 protein binding  Tat protein binding  negative regulation of protein ubiquitination  ubiquitin protein ligase binding  positive regulation of ATPase activity  DNA damage response, detection of DNA damage  positive regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of JUN kinase activity  metal ion binding  perinuclear region of cytoplasm  low-density lipoprotein particle receptor binding  unfolded protein binding  chaperone binding  chaperone binding  regulation of protein transport  C3HC4-type RING finger domain binding  extracellular exosome  protein localization to mitochondrion  cytoplasmic side of endoplasmic reticulum membrane  toxin transport  negative regulation of establishment of protein localization to mitochondrion  negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIG protein-coupled receptor binding  ATPase activator activity  protein binding  ATP binding  nucleus  mitochondrion  cytosol  cytosol  cytosol  protein folding  response to unfolded protein  spermatogenesis  response to heat  microtubule cytoskeleton  membrane  membrane  flagellated sperm motility  androgen receptor signaling pathway  Hsp70 protein binding  Tat protein binding  negative regulation of protein ubiquitination  ubiquitin protein ligase binding  positive regulation of ATPase activity  DNA damage response, detection of DNA damage  positive regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of JUN kinase activity  metal ion binding  perinuclear region of cytoplasm  low-density lipoprotein particle receptor binding  unfolded protein binding  chaperone binding  chaperone binding  regulation of protein transport  C3HC4-type RING finger domain binding  extracellular exosome  protein localization to mitochondrion  cytoplasmic side of endoplasmic reticulum membrane  toxin transport  negative regulation of establishment of protein localization to mitochondrion  negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkDNAJA1
Atlas of Cancer Signalling NetworkDNAJA1
Wikipedia pathwaysDNAJA1
Orthology - Evolution
OrthoDB3301
GeneTree (enSembl)ENSG00000086061
Phylogenetic Trees/Animal Genes : TreeFamDNAJA1
HOGENOMP31689
Homologs : HomoloGeneDNAJA1
Homology/Alignments : Family Browser (UCSC)DNAJA1
Gene fusions - Rearrangements
Fusion : MitelmanDNAJA1/GALNTL6 [9p21.1/4q34.1]  
Fusion PortalDNAJA1 9p21.1 GALNTL6 4q34.1 LGG
Fusion : QuiverDNAJA1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDNAJA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DNAJA1
dbVarDNAJA1
ClinVarDNAJA1
1000_GenomesDNAJA1 
Exome Variant ServerDNAJA1
ExAC (Exome Aggregation Consortium)ENSG00000086061
GNOMAD BrowserENSG00000086061
Varsome BrowserDNAJA1
Genetic variants : HAPMAP3301
Genomic Variants (DGV)DNAJA1 [DGVbeta]
DECIPHERDNAJA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDNAJA1 
Mutations
ICGC Data PortalDNAJA1 
TCGA Data PortalDNAJA1 
Broad Tumor PortalDNAJA1
OASIS PortalDNAJA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDNAJA1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDNAJA1
Mutations and Diseases : HGMDDNAJA1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DNAJA1
DgiDB (Drug Gene Interaction Database)DNAJA1
DoCM (Curated mutations)DNAJA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DNAJA1 (select a term)
intoGenDNAJA1
Cancer3DDNAJA1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602837   
Orphanet
DisGeNETDNAJA1
MedgenDNAJA1
Genetic Testing Registry DNAJA1
NextProtP31689 [Medical]
TSGene3301
GENETestsDNAJA1
Target ValidationDNAJA1
Huge Navigator DNAJA1 [HugePedia]
snp3D : Map Gene to Disease3301
BioCentury BCIQDNAJA1
ClinGenDNAJA1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3301
Chemical/Pharm GKB GenePA31536
Clinical trialDNAJA1
Miscellaneous
canSAR (ICR)DNAJA1 (select the gene name)
DataMed IndexDNAJA1
Probes
Litterature
PubMed187 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDNAJA1
EVEXDNAJA1
GoPubMedDNAJA1
iHOPDNAJA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:40:38 CET 2019
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