Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2)

Identity

Alias_namesDnaJ (Hsp40) homolog, subfamily A, member 2
Alias_symbol (synonym)HIRIP4
DNAJ
CPR3
DNJ3
Other aliasDJ3
DJA2
PRO3015
RDJ2
HGNC (Hugo) DNAJA2
LocusID (NCBI) 10294
Atlas_Id 46879
Location 16q11.2  [Link to chromosome band 16q11]
Location_base_pair Starts at 46955362 and ends at 46973714 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DNAJA2 (16q11.2) / ANKRD11 (16q24.3)DNAJA2 (16q11.2) / ARID1A (1p36.11)DNAJA2 (16q11.2) / COL14A1 (8q24.12)
DNAJA2 (16q11.2) / NETO2 (16q12.1)DNAJA2 (16q11.2) / SRP68 (17q25.1)EMP1 (12p13.1) / DNAJA2 (16q11.2)
TRIM9 (14q22.1) / DNAJA2 (16q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(8;16)(q24;q12) DNAJA2/COL14A1

External links

Nomenclature
HGNC (Hugo)DNAJA2   14884
Cards
Entrez_Gene (NCBI)DNAJA2  10294  DnaJ heat shock protein family (Hsp40) member A2
AliasesCPR3; DJ3; DJA2; DNAJ; 
DNJ3; HIRIP4; PRO3015; RDJ2
GeneCards (Weizmann)DNAJA2
Ensembl hg19 (Hinxton)ENSG00000069345 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000069345 [Gene_View]  ENSG00000069345 [Sequence]  chr16:46955362-46973714 [Contig_View]  DNAJA2 [Vega]
ICGC DataPortalENSG00000069345
TCGA cBioPortalDNAJA2
AceView (NCBI)DNAJA2
Genatlas (Paris)DNAJA2
WikiGenes10294
SOURCE (Princeton)DNAJA2
Genetics Home Reference (NIH)DNAJA2
Genomic and cartography
GoldenPath hg38 (UCSC)DNAJA2  -     chr16:46955362-46973714 -  16q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DNAJA2  -     16q11.2   [Description]    (hg19-Feb_2009)
GoldenPathDNAJA2 - 16q11.2 [CytoView hg19]  DNAJA2 - 16q11.2 [CytoView hg38]
ImmunoBaseENSG00000069345
Mapping of homologs : NCBIDNAJA2 [Mapview hg19]  DNAJA2 [Mapview hg38]
OMIM611322   
Gene and transcription
Genbank (Entrez)AF088046 AJ001309 AK313031 BC013044 BC015809
RefSeq transcript (Entrez)NM_005880
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DNAJA2
Cluster EST : UnigeneHs.368078 [ NCBI ]
CGAP (NCI)Hs.368078
Alternative Splicing GalleryENSG00000069345
Gene ExpressionDNAJA2 [ NCBI-GEO ]   DNAJA2 [ EBI - ARRAY_EXPRESS ]   DNAJA2 [ SEEK ]   DNAJA2 [ MEM ]
Gene Expression Viewer (FireBrowse)DNAJA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10294
GTEX Portal (Tissue expression)DNAJA2
Human Protein AtlasENSG00000069345-DNAJA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60884   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60884  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60884
Splice isoforms : SwissVarO60884
PhosPhoSitePlusO60884
Domaine pattern : Prosite (Expaxy)DNAJ_1 (PS00636)    DNAJ_2 (PS50076)    ZF_CR (PS51188)   
Domains : Interpro (EBI)DnaJ    DnaJ_C    DnaJ_domain    DnaJ_domain_CS    HSP40/DnaJ_pept-bd    HSP_DnaJ_Cys-rich_dom    HSP_DnaJ_Cys-rich_dom_sf    J_dom_sf   
Domain families : Pfam (Sanger)DnaJ (PF00226)    DnaJ_C (PF01556)    DnaJ_CXXCXGXG (PF00684)   
Domain families : Pfam (NCBI)pfam00226    pfam01556    pfam00684   
Domain families : Smart (EMBL)DnaJ (SM00271)  
Conserved Domain (NCBI)DNAJA2
DMDM Disease mutations10294
Blocks (Seattle)DNAJA2
SuperfamilyO60884
Human Protein Atlas [tissue]ENSG00000069345-DNAJA2 [tissue]
Peptide AtlasO60884
HPRD07105
IPIIPI00032406   IPI00001300   IPI00982220   
Protein Interaction databases
DIP (DOE-UCLA)O60884
IntAct (EBI)O60884
FunCoupENSG00000069345
BioGRIDDNAJA2
STRING (EMBL)DNAJA2
ZODIACDNAJA2
Ontologies - Pathways
QuickGOO60884
Ontology : AmiGOATPase activator activity  protein binding  ATP binding  cytosol  cytosol  cytosol  positive regulation of cell proliferation  response to heat  membrane  heat shock protein binding  positive regulation of ATPase activity  protein refolding  metal ion binding  unfolded protein binding  chaperone binding  extracellular exosome  
Ontology : EGO-EBIATPase activator activity  protein binding  ATP binding  cytosol  cytosol  cytosol  positive regulation of cell proliferation  response to heat  membrane  heat shock protein binding  positive regulation of ATPase activity  protein refolding  metal ion binding  unfolded protein binding  chaperone binding  extracellular exosome  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkDNAJA2
Atlas of Cancer Signalling NetworkDNAJA2
Wikipedia pathwaysDNAJA2
Orthology - Evolution
OrthoDB10294
GeneTree (enSembl)ENSG00000069345
Phylogenetic Trees/Animal Genes : TreeFamDNAJA2
HOGENOMO60884
Homologs : HomoloGeneDNAJA2
Homology/Alignments : Family Browser (UCSC)DNAJA2
Gene fusions - Rearrangements
Fusion : MitelmanDNAJA2/COL14A1 [16q11.2/8q24.12]  
Fusion : QuiverDNAJA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDNAJA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DNAJA2
dbVarDNAJA2
ClinVarDNAJA2
1000_GenomesDNAJA2 
Exome Variant ServerDNAJA2
ExAC (Exome Aggregation Consortium)ENSG00000069345
GNOMAD BrowserENSG00000069345
Varsome BrowserDNAJA2
Genetic variants : HAPMAP10294
Genomic Variants (DGV)DNAJA2 [DGVbeta]
DECIPHERDNAJA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDNAJA2 
Mutations
ICGC Data PortalDNAJA2 
TCGA Data PortalDNAJA2 
Broad Tumor PortalDNAJA2
OASIS PortalDNAJA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDNAJA2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDNAJA2
Mutations and Diseases : HGMDDNAJA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DNAJA2
DgiDB (Drug Gene Interaction Database)DNAJA2
DoCM (Curated mutations)DNAJA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DNAJA2 (select a term)
intoGenDNAJA2
Cancer3DDNAJA2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611322   
Orphanet
DisGeNETDNAJA2
MedgenDNAJA2
Genetic Testing Registry DNAJA2
NextProtO60884 [Medical]
TSGene10294
GENETestsDNAJA2
Target ValidationDNAJA2
Huge Navigator DNAJA2 [HugePedia]
snp3D : Map Gene to Disease10294
BioCentury BCIQDNAJA2
ClinGenDNAJA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10294
Chemical/Pharm GKB GenePA27409
Clinical trialDNAJA2
Miscellaneous
canSAR (ICR)DNAJA2 (select the gene name)
DataMed IndexDNAJA2
Probes
Litterature
PubMed118 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDNAJA2
EVEXDNAJA2
GoPubMedDNAJA2
iHOPDNAJA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:40:39 CET 2019
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