DNAJB1 (DnaJ heat shock protein family (Hsp40) member B1)

2007-04-01  

Identity

HGNC
LOCATION
19p13.12
LOCUSID
ALIAS
HSPF1,Hdj1,Hsp40,RSPH16B,Sis1
FUSION GENES

Other Information

Locus ID:

NCBI: 3337
MIM: 604572
HGNC: 5270
Ensembl: ENSG00000132002

Variants:

dbSNP: 3337
ClinVar: 3337
TCGA: ENSG00000132002
COSMIC: DNAJB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132002ENST00000254322P25685
ENSG00000132002ENST00000254322Q6FHS4
ENSG00000132002ENST00000396969P25685
ENSG00000132002ENST00000594099M0QZD0
ENSG00000132002ENST00000595139M0QXK0
ENSG00000132002ENST00000595992M0QYT3
ENSG00000132002ENST00000596075M0R128
ENSG00000132002ENST00000596853M0QYT3
ENSG00000132002ENST00000598235M0R080
ENSG00000132002ENST00000598692A0A1B0GX60
ENSG00000132002ENST00000601533M0R1D6

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Signal TransductionREACTOMER-HSA-162582
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK6/MAPK4 signalingREACTOMER-HSA-5687128
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
HSF1-dependent transactivationREACTOMER-HSA-3371571
Attenuation phaseREACTOMER-HSA-3371568
Regulation of HSF1-mediated heat shock responseREACTOMER-HSA-3371453

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
220226002011The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system.115
245785762014Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma.107
147431832004Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders.86
151947942004Nuclear sequestration of cellular chaperone and proteasomal machinery during herpes simplex virus type 1 infection.59
243188772014Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.50
192548102009The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids.39
212491762011Identification and characterization of the host protein DNAJC14 as a broadly active flavivirus replication modulator.34
239627242014Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones.34
255579532015Unique genomic profile of fibrolamellar hepatocellular carcinoma.33
240916762013Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110.29

Citation

Dessen P

DNAJB1 (DnaJ heat shock protein family (Hsp40) member B1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46862/dnajb1