DNAJB11 (DnaJ heat shock protein family (Hsp40) member B11)

2007-04-01  

Identity

HGNC
DNAJB11
LOCATION
3q27.3
LOCUSID
51726
ALIAS
ABBP-2,ABBP2,DJ9,Dj-9,EDJ,ERdj3,ERj3,ERj3p,PKD6,PRO1080,UNQ537
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51726
MIM: 611341
HGNC: 14889
Ensembl: ENSG00000090520

Variants:

dbSNP: 51726
ClinVar: 51726
TCGA: ENSG00000090520
COSMIC: DNAJB11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090520ENST00000265028Q9UBS4
ENSG00000090520ENST00000439351Q9UBS4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382755842023DNAJB11 Mutation in ADPKD Patients: Clinical Characteristics in a Monocentric Cohort.0
382755842023DNAJB11 Mutation in ADPKD Patients: Clinical Characteristics in a Monocentric Cohort.0
326316242020Clinical spectrum, prognosis and estimated prevalence of DNAJB11-kidney disease.24
326316242020Clinical spectrum, prognosis and estimated prevalence of DNAJB11-kidney disease.24
316241442019SDF2-like protein 1 (SDF2L1) regulates the endoplasmic reticulum localization and chaperone activity of ERdj3 protein.14
316241442019SDF2-like protein 1 (SDF2L1) regulates the endoplasmic reticulum localization and chaperone activity of ERdj3 protein.14
297063512018Monoallelic Mutations to DNAJB11 Cause Atypical Autosomal-Dominant Polycystic Kidney Disease.134
299928392018The endoplasmic reticulum co-chaperone ERdj3/DNAJB11 promotes hepatocellular carcinoma progression through suppressing AATZ degradation.6
297063512018Monoallelic Mutations to DNAJB11 Cause Atypical Autosomal-Dominant Polycystic Kidney Disease.134
299928392018The endoplasmic reticulum co-chaperone ERdj3/DNAJB11 promotes hepatocellular carcinoma progression through suppressing AATZ degradation.6
284195792017Erdj3 Has an Essential Role for Z Variant Alpha-1-Antitrypsin Degradation.12
286557542017The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer.22
287527092017[Expression and clinical significance of DNAJB11 in epithelial ovarian cancer].1
284195792017Erdj3 Has an Essential Role for Z Variant Alpha-1-Antitrypsin Degradation.12
286557542017The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer.22

Citation

Dessen P

DNAJB11 (DnaJ heat shock protein family (Hsp40) member B11)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47317/dnajb11