Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DNAJC2 (DnaJ heat shock protein family (Hsp40) member C2)

Identity

Alias (NCBI)MPHOSPH11
MPP11
ZRF1
ZUO1
HGNC (Hugo) DNAJC2
HGNC Alias symbMPP11
MPHOSPH11
ZUO1
zuotin
HGNC Previous nameZRF1
HGNC Previous namezuotin related factor 1
 DnaJ (Hsp40) homolog, subfamily C, member 2
LocusID (NCBI) 27000
Atlas_Id 42886
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 103312289 and ends at 103344767 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DNAJC2 (7q22.1) / SLC26A5 (7q22.1)DNAJC2 7q22.1 / SLC26A5 7q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  DNAJC2/SLC26A5 (7q22)

External links

Nomenclature
HGNC (Hugo)DNAJC2   13192
Cards
Entrez_Gene (NCBI)DNAJC2  27000  DnaJ heat shock protein family (Hsp40) member C2
AliasesMPHOSPH11; MPP11; ZRF1; ZUO1
GeneCards (Weizmann)DNAJC2
Ensembl hg19 (Hinxton)ENSG00000105821 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105821 [Gene_View]  ENSG00000105821 [Sequence]  chr7:103312289-103344767 [Contig_View]  DNAJC2 [Vega]
ICGC DataPortalENSG00000105821
TCGA cBioPortalDNAJC2
AceView (NCBI)DNAJC2
Genatlas (Paris)DNAJC2
WikiGenes27000
SOURCE (Princeton)DNAJC2
Genetics Home Reference (NIH)DNAJC2
Genomic and cartography
GoldenPath hg38 (UCSC)DNAJC2  -     chr7:103312289-103344767 -  7q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DNAJC2  -     7q22.1   [Description]    (hg19-Feb_2009)
GoldenPathDNAJC2 - 7q22.1 [CytoView hg19]  DNAJC2 - 7q22.1 [CytoView hg38]
ImmunoBaseENSG00000105821
genome Data Viewer NCBIDNAJC2 [Mapview hg19]  
OMIM605502   
Gene and transcription
Genbank (Entrez)AI140595 AI621015 AK126382 AL832847 BC000859
RefSeq transcript (Entrez)NM_001129887 NM_001362667 NM_001362668 NM_014377
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DNAJC2
Alternative Splicing GalleryENSG00000105821
Gene ExpressionDNAJC2 [ NCBI-GEO ]   DNAJC2 [ EBI - ARRAY_EXPRESS ]   DNAJC2 [ SEEK ]   DNAJC2 [ MEM ]
Gene Expression Viewer (FireBrowse)DNAJC2 [ Firebrowse - Broad ]
GenevisibleExpression of DNAJC2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27000
GTEX Portal (Tissue expression)DNAJC2
Human Protein AtlasENSG00000105821-DNAJC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99543   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99543  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99543
Splice isoforms : SwissVarQ99543
PhosPhoSitePlusQ99543
Domaine pattern : Prosite (Expaxy)DNAJ_1 (PS00636)    DNAJ_2 (PS50076)    SANT (PS51293)   
Domains : Interpro (EBI)DnaJ_domain    DnaJ_domain_CS    Homeobox-like_sf    J_dom_sf    RAC_head    RAC_head_sf    SANT/Myb    SANT_dom   
Domain families : Pfam (Sanger)DnaJ (PF00226)    Myb_DNA-binding (PF00249)    RAC_head (PF16717)   
Domain families : Pfam (NCBI)pfam00226    pfam00249    pfam16717   
Domain families : Smart (EMBL)DnaJ (SM00271)  SANT (SM00717)  
Conserved Domain (NCBI)DNAJC2
DMDM Disease mutations27000
Blocks (Seattle)DNAJC2
PDB (RSDB)2M2E    6CGH   
PDB Europe2M2E    6CGH   
PDB (PDBSum)2M2E    6CGH   
PDB (IMB)2M2E    6CGH   
Structural Biology KnowledgeBase2M2E    6CGH   
SCOP (Structural Classification of Proteins)2M2E    6CGH   
CATH (Classification of proteins structures)2M2E    6CGH   
SuperfamilyQ99543
Human Protein Atlas [tissue]ENSG00000105821-DNAJC2 [tissue]
Peptide AtlasQ99543
IPIIPI00830108   IPI00455199   IPI01009945   IPI00925609   IPI00448317   IPI00925154   IPI00924488   
Protein Interaction databases
DIP (DOE-UCLA)Q99543
IntAct (EBI)Q99543
FunCoupENSG00000105821
BioGRIDDNAJC2
STRING (EMBL)DNAJC2
ZODIACDNAJC2
Ontologies - Pathways
QuickGOQ99543
Ontology : AmiGODNA binding  chromatin binding  RNA binding  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  cytosol  DNA replication  chromatin organization  Hsp70 protein binding  nuclear membrane  histone binding  positive regulation of transcription, DNA-templated  'de novo' cotranslational protein folding  ubiquitin modification-dependent histone binding  regulation of cellular response to heat  negative regulation of DNA biosynthetic process  
Ontology : EGO-EBIDNA binding  chromatin binding  RNA binding  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  cytosol  DNA replication  chromatin organization  Hsp70 protein binding  nuclear membrane  histone binding  positive regulation of transcription, DNA-templated  'de novo' cotranslational protein folding  ubiquitin modification-dependent histone binding  regulation of cellular response to heat  negative regulation of DNA biosynthetic process  
NDEx NetworkDNAJC2
Atlas of Cancer Signalling NetworkDNAJC2
Wikipedia pathwaysDNAJC2
Orthology - Evolution
OrthoDB27000
GeneTree (enSembl)ENSG00000105821
Phylogenetic Trees/Animal Genes : TreeFamDNAJC2
HOGENOMQ99543
Homologs : HomoloGeneDNAJC2
Homology/Alignments : Family Browser (UCSC)DNAJC2
Gene fusions - Rearrangements
Fusion : MitelmanDNAJC2/SLC26A5 [7q22.1/7q22.1]  
Fusion PortalDNAJC2 7q22.1 SLC26A5 7q22.1 LUSC
Fusion : QuiverDNAJC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDNAJC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DNAJC2
dbVarDNAJC2
ClinVarDNAJC2
1000_GenomesDNAJC2 
Exome Variant ServerDNAJC2
GNOMAD BrowserENSG00000105821
Varsome BrowserDNAJC2
Genetic variants : HAPMAP27000
Genomic Variants (DGV)DNAJC2 [DGVbeta]
DECIPHERDNAJC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDNAJC2 
Mutations
ICGC Data PortalDNAJC2 
TCGA Data PortalDNAJC2 
Broad Tumor PortalDNAJC2
OASIS PortalDNAJC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDNAJC2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDNAJC2
Mutations and Diseases : HGMDDNAJC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DNAJC2
DgiDB (Drug Gene Interaction Database)DNAJC2
DoCM (Curated mutations)DNAJC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DNAJC2 (select a term)
intoGenDNAJC2
Cancer3DDNAJC2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605502   
Orphanet
DisGeNETDNAJC2
MedgenDNAJC2
Genetic Testing Registry DNAJC2
NextProtQ99543 [Medical]
TSGene27000
GENETestsDNAJC2
Target ValidationDNAJC2
Huge Navigator DNAJC2 [HugePedia]
snp3D : Map Gene to Disease27000
BioCentury BCIQDNAJC2
ClinGenDNAJC2
Clinical trials, drugs, therapy
Protein Interactions : CTD27000
Pharm GKB GenePA162383835
Clinical trialDNAJC2
Miscellaneous
canSAR (ICR)DNAJC2 (select the gene name)
HarmonizomeDNAJC2
DataMed IndexDNAJC2
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDNAJC2
EVEXDNAJC2
GoPubMedDNAJC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jul 16 15:10:57 CEST 2020
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