DNAJC3 (DnaJ heat shock protein family (Hsp40) member C3)

2007-04-01  

Identity

HGNC
LOCATION
13q32.1
LOCUSID
ALIAS
ACPHD,ERdj6,HP58,P58,P58IPK,PRKRI,p58(IPK)
FUSION GENES

Other Information

Locus ID:

NCBI: 5611
MIM: 601184
HGNC: 9439
Ensembl: ENSG00000102580

Variants:

dbSNP: 5611
ClinVar: 5611
TCGA: ENSG00000102580
COSMIC: DNAJC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102580ENST00000376795X6R9L0
ENSG00000102580ENST00000602402Q13217
ENSG00000102580ENST00000602402A8KA82

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Influenza InfectionREACTOMER-HSA-168254
Influenza Life CycleREACTOMER-HSA-168255
Influenza Viral RNA Transcription and ReplicationREACTOMER-HSA-168273
Viral mRNA TranslationREACTOMER-HSA-192823
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
126010122003P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling.89
205547762010Coxsackievirus B3 infection activates the unfolded protein response and induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1.36
254668702014Absence of BiP co-chaperone DNAJC3 causes diabetes mellitus and multisystemic neurodegeneration.30
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
185681302008P58(IPK) inhibition of endoplasmic reticulum stress in human retinal capillary endothelial cells in vitro.16
220643212012ERp29 induces breast cancer cell growth arrest and survival through modulation of activation of p38 and upregulation of ER stress protein p58IPK.14
253295452015p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity.13
217998292011The crystal structure of the human co-chaperone P58(IPK).8
306524142019Long noncoding RNA DNAJC3-AS1 promotes osteosarcoma progression via its sense-cognate gene DNAJC3.6
241345182014P58(IPK) inhibits coxsackievirus-induced apoptosis via the PI3K/Akt pathway requiring activation of ATF6a and subsequent upregulation of mitofusin 2.5

Citation

Dessen P

DNAJC3 (DnaJ heat shock protein family (Hsp40) member C3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47117/dnajc3