Identity
HGNC
LOCATION
13q32.1
LOCUSID
ALIAS
ACPHD,ERdj6,HP58,P58,P58IPK,PRKRI,p58(IPK)
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5611
MIM: 601184
HGNC: 9439
Ensembl: ENSG00000102580
Variants:
dbSNP: 5611
ClinVar: 5611
TCGA: ENSG00000102580
COSMIC: DNAJC3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000102580 | ENST00000376795 | X6R9L0 |
| ENSG00000102580 | ENST00000602402 | Q13217 |
| ENSG00000102580 | ENST00000602402 | A8KA82 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34654017 | 2022 | Biallelic DNAJC3 variants in a neuroendocrine developmental disorder with insulin dysregulation. | 3 |
| 35054769 | 2022 | Reduced DNAJC3 Expression Affects Protein Translocation across the ER Membrane and Attenuates the Down-Modulating Effect of the Translocation Inhibitor Cyclotriazadisulfonamide. | 5 |
| 34654017 | 2022 | Biallelic DNAJC3 variants in a neuroendocrine developmental disorder with insulin dysregulation. | 3 |
| 35054769 | 2022 | Reduced DNAJC3 Expression Affects Protein Translocation across the ER Membrane and Attenuates the Down-Modulating Effect of the Translocation Inhibitor Cyclotriazadisulfonamide. | 5 |
| 33486469 | 2021 | DNAJC3 deficiency induces β-cell mitochondrial apoptosis and causes syndromic young-onset diabetes. | 19 |
| 33486469 | 2021 | DNAJC3 deficiency induces β-cell mitochondrial apoptosis and causes syndromic young-onset diabetes. | 19 |
| 32738013 | 2020 | Novel insights into diabetes mellitus due to DNAJC3-defect: Evolution of neurological and endocrine phenotype in the pediatric age group. | 7 |
| 32738013 | 2020 | Novel insights into diabetes mellitus due to DNAJC3-defect: Evolution of neurological and endocrine phenotype in the pediatric age group. | 7 |
| 30652414 | 2019 | Long noncoding RNA DNAJC3-AS1 promotes osteosarcoma progression via its sense-cognate gene DNAJC3. | 10 |
| 30652414 | 2019 | Long noncoding RNA DNAJC3-AS1 promotes osteosarcoma progression via its sense-cognate gene DNAJC3. | 10 |
| 29767246 | 2018 | DNAJC3 mutation in Thai familial type 2 diabetes mellitus. | 2 |
| 29767246 | 2018 | DNAJC3 mutation in Thai familial type 2 diabetes mellitus. | 2 |
| 25329545 | 2015 | p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity. | 28 |
| 25329545 | 2015 | p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity. | 28 |
| 24134518 | 2014 | P58(IPK) inhibits coxsackievirus-induced apoptosis via the PI3K/Akt pathway requiring activation of ATF6a and subsequent upregulation of mitofusin 2. | 6 |
Citation
Dessen P
DNAJC3 (DnaJ heat shock protein family (Hsp40) member C3)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/47117/dnajc3
