Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DNASE1L3 (deoxyribonuclease 1 like 3)

Identity

Alias_namesdeoxyribonuclease I like 3
Alias_symbol (synonym)DNAS1L3
LSD
Other aliasDHP2
SLEB16
HGNC (Hugo) DNASE1L3
LocusID (NCBI) 1776
Atlas_Id 43705
Location 3p14.3  [Link to chromosome band 3p14]
Location_base_pair Starts at 58192257 and ends at 58210972 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BTBD9 (6p21.2) / DNASE1L3 (3p14.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DNASE1L3   2959
Cards
Entrez_Gene (NCBI)DNASE1L3  1776  deoxyribonuclease 1 like 3
AliasesDHP2; DNAS1L3; LSD; SLEB16
GeneCards (Weizmann)DNASE1L3
Ensembl hg19 (Hinxton)ENSG00000163687 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163687 [Gene_View]  ENSG00000163687 [Sequence]  chr3:58192257-58210972 [Contig_View]  DNASE1L3 [Vega]
ICGC DataPortalENSG00000163687
TCGA cBioPortalDNASE1L3
AceView (NCBI)DNASE1L3
Genatlas (Paris)DNASE1L3
WikiGenes1776
SOURCE (Princeton)DNASE1L3
Genetics Home Reference (NIH)DNASE1L3
Genomic and cartography
GoldenPath hg38 (UCSC)DNASE1L3  -     chr3:58192257-58210972 -  3p14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DNASE1L3  -     3p14.3   [Description]    (hg19-Feb_2009)
GoldenPathDNASE1L3 - 3p14.3 [CytoView hg19]  DNASE1L3 - 3p14.3 [CytoView hg38]
Genome Data Viewer NCBIDNASE1L3 [Mapview hg19]  
OMIM602244   614420   
Gene and transcription
Genbank (Entrez)AB209613 AF047354 AI591302 AI660448 AK131323
RefSeq transcript (Entrez)NM_001256560 NM_004944
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DNASE1L3
Alternative Splicing GalleryENSG00000163687
Gene ExpressionDNASE1L3 [ NCBI-GEO ]   DNASE1L3 [ EBI - ARRAY_EXPRESS ]   DNASE1L3 [ SEEK ]   DNASE1L3 [ MEM ]
Gene Expression Viewer (FireBrowse)DNASE1L3 [ Firebrowse - Broad ]
GenevisibleExpression of DNASE1L3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1776
GTEX Portal (Tissue expression)DNASE1L3
Human Protein AtlasENSG00000163687-DNASE1L3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13609   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13609  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13609
Splice isoforms : SwissVarQ13609
Catalytic activity : Enzyme3.1.21.- [ Enzyme-Expasy ]   3.1.21.-3.1.21.- [ IntEnz-EBI ]   3.1.21.- [ BRENDA ]   3.1.21.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ13609
Domaine pattern : Prosite (Expaxy)DNASE_I_1 (PS00919)    DNASE_I_2 (PS00918)   
Domains : Interpro (EBI)Deoxyribonuclease-1_AS    DNase_I    DNASE_I_2    Endo/exonu/phosph_ase_sf    Endo/exonuclease/phosphatase   
Domain families : Pfam (Sanger)Exo_endo_phos (PF03372)   
Domain families : Pfam (NCBI)pfam03372   
Domain families : Smart (EMBL)DNaseIc (SM00476)  
Conserved Domain (NCBI)DNASE1L3
DMDM Disease mutations1776
SuperfamilyQ13609
Human Protein Atlas [tissue]ENSG00000163687-DNASE1L3 [tissue]
Peptide AtlasQ13609
HPRD03764
IPIIPI00014286   IPI00556647   IPI00794614   IPI00982374   IPI00921818   IPI00946300   IPI00944942   
Protein Interaction databases
DIP (DOE-UCLA)Q13609
IntAct (EBI)Q13609
FunCoupENSG00000163687
BioGRIDDNASE1L3
STRING (EMBL)DNASE1L3
ZODIACDNASE1L3
Ontologies - Pathways
QuickGOQ13609
Ontology : AmiGODNA catabolic process, endonucleolytic  neutrophil activation involved in immune response  regulation of acute inflammatory response  DNA binding  deoxyribonuclease I activity  deoxyribonuclease activity  calcium ion binding  extracellular region  nucleus  nucleus  endoplasmic reticulum  DNA metabolic process  DNA catabolic process  apoptotic DNA fragmentation  apoptotic DNA fragmentation  programmed cell death involved in cell development  regulation of neutrophil mediated cytotoxicity  
Ontology : EGO-EBIDNA catabolic process, endonucleolytic  neutrophil activation involved in immune response  regulation of acute inflammatory response  DNA binding  deoxyribonuclease I activity  deoxyribonuclease activity  calcium ion binding  extracellular region  nucleus  nucleus  endoplasmic reticulum  DNA metabolic process  DNA catabolic process  apoptotic DNA fragmentation  apoptotic DNA fragmentation  programmed cell death involved in cell development  regulation of neutrophil mediated cytotoxicity  
NDEx NetworkDNASE1L3
Atlas of Cancer Signalling NetworkDNASE1L3
Wikipedia pathwaysDNASE1L3
Orthology - Evolution
OrthoDB1776
GeneTree (enSembl)ENSG00000163687
Phylogenetic Trees/Animal Genes : TreeFamDNASE1L3
HOGENOMQ13609
Homologs : HomoloGeneDNASE1L3
Homology/Alignments : Family Browser (UCSC)DNASE1L3
Gene fusions - Rearrangements
Fusion : QuiverDNASE1L3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDNASE1L3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DNASE1L3
dbVarDNASE1L3
ClinVarDNASE1L3
1000_GenomesDNASE1L3 
Exome Variant ServerDNASE1L3
GNOMAD BrowserENSG00000163687
Varsome BrowserDNASE1L3
Genetic variants : HAPMAP1776
Genomic Variants (DGV)DNASE1L3 [DGVbeta]
DECIPHERDNASE1L3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDNASE1L3 
Mutations
ICGC Data PortalDNASE1L3 
TCGA Data PortalDNASE1L3 
Broad Tumor PortalDNASE1L3
OASIS PortalDNASE1L3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDNASE1L3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDNASE1L3
Mutations and Diseases : HGMDDNASE1L3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect DNASE1L3
DgiDB (Drug Gene Interaction Database)DNASE1L3
DoCM (Curated mutations)DNASE1L3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DNASE1L3 (select a term)
intoGenDNASE1L3
Cancer3DDNASE1L3 (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602244    614420   
Orphanet21114    10428   
DisGeNETDNASE1L3
MedgenDNASE1L3
Genetic Testing Registry DNASE1L3
NextProtQ13609 [Medical]
TSGene1776
GENETestsDNASE1L3
Open Targets GeneticsENSG00000163687  [validation]
snp3D : Map Gene to Disease1776
BioCentury BCIQDNASE1L3
ClinGenDNASE1L3
Clinical trials, drugs, therapy
Protein Interactions : CTD1776
Pharm GKB GenePA27430
Clinical trialDNASE1L3
Miscellaneous
canSAR (ICR)DNASE1L3 (select the gene name)
HarmonizomeDNASE1L3
DataMed IndexDNASE1L3
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDNASE1L3
EVEXDNASE1L3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jul 11 19:46:39 CEST 2020
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