DNMT3L (DNA methyltransferase 3 like)

2007-04-01  

Identity

HGNC
LOCATION
21q22.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 29947
MIM: 606588
HGNC: 2980
Ensembl: ENSG00000142182

Variants:

dbSNP: 29947
ClinVar: 29947
TCGA: ENSG00000142182
COSMIC: DNMT3L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142182ENST00000270172Q9UJW3
ENSG00000142182ENST00000431166C9J0T5
ENSG00000142182ENST00000628202Q9UJW3

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
DNA methylationREACTOMER-HSA-5334118

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
176873272007DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA.537
177134772007Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation.268
124810292002The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a.135
151054262004DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction.121
253835302015Structural insight into autoinhibition and histone H3-induced activation of DNMT3A.84
168295252006Reconstitution and mechanism of the stimulation of de novo methylation by human DNMT3L.56
208385922010DNMT3L modulates significant and distinct flanking sequence preference for DNA methylation by DNMT3A and DNMT3B in vivo.50
206308732010The inherent processivity of the human de novo methyltransferase 3A (DNMT3A) is enhanced by DNMT3L.37
162115982006Meiotic and epigenetic aberrations in Dnmt3L-deficient male germ cells.25
165751652006Evolution of the vertebrate DNMT3 gene family: a possible link between existence of DNMT3L and genomic imprinting.24

Citation

Dessen P

DNMT3L (DNA methyltransferase 3 like)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46801/dnmt3l