DNPEP (aspartyl aminopeptidase)

2013-12-01  

Identity

HGNC
DNPEP
LOCATION
2q35
LOCUSID
23549
ALIAS
ASPEP,DAP

Other Information

Locus ID:

NCBI: 23549
MIM: 611367
HGNC: 2981
Ensembl: ENSG00000123992

Variants:

dbSNP: 23549
ClinVar: 23549
TCGA: ENSG00000123992
COSMIC: DNPEP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123992ENST00000273075Q9ULA0
ENSG00000123992ENST00000322176B9ZVU2
ENSG00000123992ENST00000373963E3W974
ENSG00000123992ENST00000373966E3W979
ENSG00000123992ENST00000373972E7EMB6
ENSG00000123992ENST00000429013F8WAN0
ENSG00000123992ENST00000430206C9JRG3
ENSG00000123992ENST00000434339C9J1E2
ENSG00000123992ENST00000457935C9JBE1
ENSG00000123992ENST00000519698E5RHR3
ENSG00000123992ENST00000519905E5RJ35
ENSG00000123992ENST00000520694A0A024R442
ENSG00000123992ENST00000521459E7EPX3
ENSG00000123992ENST00000523282E7ETB3

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
227207942012Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family.12
124134882002Identification of histidine residues important in the catalysis and structure of aspartyl aminopeptidase.8
239484432013Clinical impact of aspartyl aminopeptidase expression and activity in colorectal cancer.5

Citation

Dessen P

DNPEP (aspartyl aminopeptidase)

Atlas Genet Cytogenet Oncol Haematol. 2013-12-01

Online version: http://atlasgeneticsoncology.org/gene/53746/dnpep