DOCK2 (dedicator of cytokinesis 2)

2007-02-01  

Identity

HGNC
DOCK2
LOCATION
5q35.1
LOCUSID
1794
ALIAS
IMD40
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1794
MIM: 603122
HGNC: 2988
Ensembl: ENSG00000134516

Variants:

dbSNP: 1794
ClinVar: 1794
TCGA: ENSG00000134516
COSMIC: DOCK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134516ENST00000433448H7C082
ENSG00000134516ENST00000519628H0YB76
ENSG00000134516ENST00000519734A0A3B3IRS9
ENSG00000134516ENST00000520908Q92608
ENSG00000134516ENST00000523684A0A3B3ISB1
ENSG00000134516ENST00000524185E5RFJ0
ENSG00000134516ENST00000540750F6S220

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
Host Interactions of HIV factorsREACTOMER-HSA-162909
The role of Nef in HIV-1 replication and disease pathogenesisREACTOMER-HSA-164952
Nef and signal transductionREACTOMER-HSA-164944
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
235250772013Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity.278
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
260832062015Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections.50
147371862004HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis.49
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
128295962003DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1.40
239119892013Immune regulatory functions of DOCK family proteins in health and disease.30
186629842008Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.29
216451502011CXCL13 mediates prostate cancer cell proliferation through JNK signalling and invasion through ERK activation.27

Citation

Dessen P

DOCK2 (dedicator of cytokinesis 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46570/dock2