DOHH (deoxyhypusine hydroxylase)

2013-01-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
HLRC1,hDOHH

Other Information

Locus ID:

NCBI: 83475
MIM: 611262
HGNC: 28662
Ensembl: ENSG00000129932

Variants:

dbSNP: 83475
ClinVar: 83475
TCGA: ENSG00000129932
COSMIC: DOHH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129932ENST00000427575Q9BU89

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Gamma carboxylation, hypusine formation and arylsulfatase activationREACTOMER-HSA-163841
Hypusine synthesis from eIF5A-lysineREACTOMER-HSA-204626

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
197064222009Human deoxyhypusine hydroxylase, an enzyme involved in regulating cell growth, activates O2 with a nonheme diiron center.49
248431202014Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase.36
165338142006Deoxyhypusine hydroxylase is a Fe(II)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis [corrected].19
229082212012Regulation of expression of deoxyhypusine hydroxylase (DOHH), the enzyme that catalyzes the activation of eIF5A, by miR-331-3p and miR-642-5p in prostate cancer cells.19
229279712012Expression of eukaryotic initiation factor 5A and hypusine forming enzymes in glioblastoma patient samples: implications for new targeted therapies.16
172131972007Specificity of the deoxyhypusine hydroxylase-eukaryotic translation initiation factor (eIF5A) interaction: identification of amino acid residues of the enzyme required for binding of its substrate, deoxyhypusine-containing eIF5A.14
258652442015Crystal Structure of the Peroxo-diiron(III) Intermediate of Deoxyhypusine Hydroxylase, an Oxygenase Involved in Hypusination.14

Citation

Dessen P

DOHH (deoxyhypusine hydroxylase)

Atlas Genet Cytogenet Oncol Haematol. 2013-01-01

Online version: http://atlasgeneticsoncology.org/gene/53136/dohh