DOK1 (docking protein 1)

2003-02-01  

Identity

HGNC
LOCATION
2p13.1
LOCUSID
ALIAS
P62DOK,pp62

Other Information

Locus ID:

NCBI: 1796
MIM: 602919
HGNC: 2990
Ensembl: ENSG00000115325

Variants:

dbSNP: 1796
ClinVar: 1796
TCGA: ENSG00000115325
COSMIC: DOK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115325ENST00000233668Q99704
ENSG00000115325ENST00000340004Q99704
ENSG00000115325ENST00000409429Q99704
ENSG00000115325ENST00000429631H7C093

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Signal TransductionREACTOMER-HSA-162582
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Signaling by PTK6REACTOMER-HSA-8848021
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1REACTOMER-HSA-8849469
RET signalingREACTOMER-HSA-8853659

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
201399802010Identification of DOK genes as lung tumor suppressors.47
181561752008An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding.38
155744992004IkappaB kinase beta phosphorylates Dok1 serines in response to TNF, IL-1, or gamma radiation.23
210789072010Downstream of tyrosine kinase 1 and 2 play opposing roles in CD200 receptor signaling.23
216902892011The Ras inhibitors caveolin-1 and docking protein 1 activate peroxisome proliferator-activated receptor γ through spatial relocalization at helix 7 of its ligand-binding domain.22
192996942009Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells.20
155468842005DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells.18
165378942006Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis.17
196822412009Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions.16
218562572011Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer.15

Citation

Dessen P

DOK1 (docking protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40356/dok1