DPF3 (double PHD fingers 3)

2014-08-01  

Identity

HGNC
DPF3
LOCATION
14q24.2
LOCUSID
8110
ALIAS
BAF45C,CERD4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8110
MIM: 601672
HGNC: 17427
Ensembl: ENSG00000205683

Variants:

dbSNP: 8110
ClinVar: 8110
TCGA: ENSG00000205683
COSMIC: DPF3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000205683ENST00000366353F8W7T1
ENSG00000205683ENST00000381216Q92784
ENSG00000205683ENST00000541685Q92784
ENSG00000205683ENST00000546183Q92784
ENSG00000205683ENST00000556509Q92784
ENSG00000205683ENST00000610283F8W7T1
ENSG00000205683ENST00000614862Q92784

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
206138432010Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b.113
187657892008Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.90
189786782008Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.21
223347082012Double plant homeodomain (PHD) finger proteins DPF3a and -3b are required as transcriptional co-activators in SWI/SNF complex-dependent activation of NF-κB RelA/p50 heterodimer.15
265829132016Phosphorylation of the chromatin remodeling factor DPF3a induces cardiac hypertrophy through releasing HEY repressors from DNA.13
161091802005Genetic polymorphisms in DPF3 associated with risk of breast cancer and lymph node metastases.5
251207732014Expression profiles of HA117 and its neighboring gene DPF3 in different colon segments of Hirschsprung's disease.5
274025332016Crystal structure of DPF3b in complex with an acetylated histone peptide.5
241558902013Identification of a STAT5 target gene, Dpf3, provides novel insights in chronic lymphocytic leukemia.4
272328522017Strong association of SLC1A1 and DPF3 gene variants with idiopathic male infertility in Han Chinese.4

Citation

Dessen P

DPF3 (double PHD fingers 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54263/dpf3