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DPH6 (diphthamine biosynthesis 6)

Identity

Alias (NCBI)ATPBD4
HGNC (Hugo) DPH6
HGNC Alias symbMGC14798
HGNC Alias namediphthine--ammonia ligase
HGNC Previous nameATPBD4
HGNC Previous nameATP binding domain 4
 DPH6 homolog (S. cerevisiae)
LocusID (NCBI) 89978
Atlas_Id 62609
Location 15q14  [Link to chromosome band 15q14]
Location_base_pair Starts at 35370969 and ends at 35546203 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATP8B4 (15q21.2) / DPH6 (15q14)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(15;15)(q14;q21) ATP8B4/DPH6


External links

Nomenclature
HGNC (Hugo)DPH6   30543
Cards
Entrez_Gene (NCBI)DPH6    diphthamine biosynthesis 6
AliasesATPBD4
GeneCards (Weizmann)DPH6
Ensembl hg19 (Hinxton)ENSG00000134146 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134146 [Gene_View]  ENSG00000134146 [Sequence]  chr15:35370969-35546203 [Contig_View]  DPH6 [Vega]
ICGC DataPortalENSG00000134146
TCGA cBioPortalDPH6
AceView (NCBI)DPH6
Genatlas (Paris)DPH6
SOURCE (Princeton)DPH6
Genetics Home Reference (NIH)DPH6
Genomic and cartography
GoldenPath hg38 (UCSC)DPH6  -     chr15:35370969-35546203 -  15q14   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DPH6  -     15q14   [Description]    (hg19-Feb_2009)
GoldenPathDPH6 - 15q14 [CytoView hg19]  DPH6 - 15q14 [CytoView hg38]
ImmunoBaseENSG00000134146
genome Data Viewer NCBIDPH6 [Mapview hg19]  
OMIM618391   
Gene and transcription
Genbank (Entrez)AK094007 AK125017 AL833427 BC008485 BC066652
RefSeq transcript (Entrez)NM_001141972 NM_080650
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DPH6
Alternative Splicing GalleryENSG00000134146
Gene ExpressionDPH6 [ NCBI-GEO ]   DPH6 [ EBI - ARRAY_EXPRESS ]   DPH6 [ SEEK ]   DPH6 [ MEM ]
Gene Expression Viewer (FireBrowse)DPH6 [ Firebrowse - Broad ]
GenevisibleExpression of DPH6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)89978
GTEX Portal (Tissue expression)DPH6
Human Protein AtlasENSG00000134146-DPH6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7L8W6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7L8W6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7L8W6
Splice isoforms : SwissVarQ7L8W6
Catalytic activity : Enzyme6.3.1.14 [ Enzyme-Expasy ]   6.3.1.146.3.1.14 [ IntEnz-EBI ]   6.3.1.14 [ BRENDA ]   6.3.1.14 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ7L8W6
Domains : Interpro (EBI)Diphthami_syn_dom    DPH6/MJ0570    Rossmann-like_a/b/a_fold   
Domain families : Pfam (Sanger)Diphthami_syn_2 (PF01902)   
Domain families : Pfam (NCBI)pfam01902   
Conserved Domain (NCBI)DPH6
Blocks (Seattle)DPH6
SuperfamilyQ7L8W6
Human Protein Atlas [tissue]ENSG00000134146-DPH6 [tissue]
Peptide AtlasQ7L8W6
HPRD14443
IPIIPI00063121   IPI00903052   
Protein Interaction databases
DIP (DOE-UCLA)Q7L8W6
IntAct (EBI)Q7L8W6
BioGRIDDPH6
STRING (EMBL)DPH6
ZODIACDPH6
Ontologies - Pathways
QuickGOQ7L8W6
Ontology : AmiGOATP binding  nucleoplasm  nucleolus  cytosol  diphthine-ammonia ligase activity  diphthine-ammonia ligase activity  diphthine-ammonia ligase activity  peptidyl-diphthamide biosynthetic process from peptidyl-histidine  peptidyl-diphthamide biosynthetic process from peptidyl-histidine  peptidyl-diphthamide biosynthetic process from peptidyl-histidine  
Ontology : EGO-EBIATP binding  nucleoplasm  nucleolus  cytosol  diphthine-ammonia ligase activity  diphthine-ammonia ligase activity  diphthine-ammonia ligase activity  peptidyl-diphthamide biosynthetic process from peptidyl-histidine  peptidyl-diphthamide biosynthetic process from peptidyl-histidine  peptidyl-diphthamide biosynthetic process from peptidyl-histidine  
NDEx NetworkDPH6
Atlas of Cancer Signalling NetworkDPH6
Wikipedia pathwaysDPH6
Orthology - Evolution
OrthoDB89978
GeneTree (enSembl)ENSG00000134146
Phylogenetic Trees/Animal Genes : TreeFamDPH6
HOGENOMQ7L8W6
Homologs : HomoloGeneDPH6
Homology/Alignments : Family Browser (UCSC)DPH6
Gene fusions - Rearrangements
Fusion : QuiverDPH6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDPH6 [hg38]
dbVarDPH6
ClinVarDPH6
MonarchDPH6
1000_GenomesDPH6 
Exome Variant ServerDPH6
GNOMAD BrowserENSG00000134146
Varsome BrowserDPH6
Genomic Variants (DGV)DPH6 [DGVbeta]
DECIPHERDPH6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDPH6 
Mutations
ICGC Data PortalDPH6 
TCGA Data PortalDPH6 
Broad Tumor PortalDPH6
OASIS PortalDPH6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDPH6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDPH6
Mutations and Diseases : HGMDDPH6
BioMutasearch DPH6
DgiDB (Drug Gene Interaction Database)DPH6
DoCM (Curated mutations)DPH6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DPH6 (select a term)
intoGenDPH6
Cancer3DDPH6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM618391   
Orphanet
DisGeNETDPH6
MedgenDPH6
Genetic Testing Registry DPH6
NextProtQ7L8W6 [Medical]
GENETestsDPH6
Target ValidationDPH6
Huge Navigator DPH6 [HugePedia]
ClinGenDPH6
Clinical trials, drugs, therapy
MyCancerGenomeDPH6
Protein Interactions : CTD
Pharm GKB GenePA142672572
Clinical trialDPH6
Miscellaneous
canSAR (ICR)DPH6 (select the gene name)
HarmonizomeDPH6
DataMed IndexDPH6
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDPH6
EVEXDPH6
GoPubMedDPH6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Dec 5 16:52:13 CET 2020

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