Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DPYS (dihydropyrimidinase)

Identity

Alias_symbol (synonym)DHPase
Other aliasDHP
HGNC (Hugo) DPYS
LocusID (NCBI) 1807
Atlas_Id 43232
Location 8q22.3  [Link to chromosome band 8q22]
Location_base_pair Starts at 104379424 and ends at 104467049 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
VPS13B (8q22.2) / DPYS (8q22.3)VPS13B 8q22.2 / DPYS 8q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  VPS13B/DPYS (8q22)

External links

Nomenclature
HGNC (Hugo)DPYS   3013
Cards
Entrez_Gene (NCBI)DPYS  1807  dihydropyrimidinase
AliasesDHP; DHPase
GeneCards (Weizmann)DPYS
Ensembl hg19 (Hinxton)ENSG00000147647 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000147647 [Gene_View]  ENSG00000147647 [Sequence]  chr8:104379424-104467049 [Contig_View]  DPYS [Vega]
ICGC DataPortalENSG00000147647
TCGA cBioPortalDPYS
AceView (NCBI)DPYS
Genatlas (Paris)DPYS
WikiGenes1807
SOURCE (Princeton)DPYS
Genetics Home Reference (NIH)DPYS
Genomic and cartography
GoldenPath hg38 (UCSC)DPYS  -     chr8:104379424-104467049 -  8q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DPYS  -     8q22.3   [Description]    (hg19-Feb_2009)
GoldenPathDPYS - 8q22.3 [CytoView hg19]  DPYS - 8q22.3 [CytoView hg38]
ImmunoBaseENSG00000147647
Mapping of homologs : NCBIDPYS [Mapview hg19]  DPYS [Mapview hg38]
OMIM222748   613326   
Gene and transcription
Genbank (Entrez)AK311261 BC034395 D78011
RefSeq transcript (Entrez)NM_001385
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DPYS
Cluster EST : UnigeneHs.443161 [ NCBI ]
CGAP (NCI)Hs.443161
Alternative Splicing GalleryENSG00000147647
Gene ExpressionDPYS [ NCBI-GEO ]   DPYS [ EBI - ARRAY_EXPRESS ]   DPYS [ SEEK ]   DPYS [ MEM ]
Gene Expression Viewer (FireBrowse)DPYS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1807
GTEX Portal (Tissue expression)DPYS
Human Protein AtlasENSG00000147647-DPYS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14117   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14117  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14117
Splice isoforms : SwissVarQ14117
PhosPhoSitePlusQ14117
Domains : Interpro (EBI)Amidohydro-rel    Hydantoinase/dihydroPyrase    Metal-dep_hydrolase_composite    Metal_Hydrolase   
Domain families : Pfam (Sanger)Amidohydro_1 (PF01979)   
Domain families : Pfam (NCBI)pfam01979   
Conserved Domain (NCBI)DPYS
DMDM Disease mutations1807
Blocks (Seattle)DPYS
PDB (RSDB)2VR2   
PDB Europe2VR2   
PDB (PDBSum)2VR2   
PDB (IMB)2VR2   
Structural Biology KnowledgeBase2VR2   
SCOP (Structural Classification of Proteins)2VR2   
CATH (Classification of proteins structures)2VR2   
SuperfamilyQ14117
Human Protein Atlas [tissue]ENSG00000147647-DPYS [tissue]
Peptide AtlasQ14117
HPRD01960
IPIIPI00028910   IPI00973715   IPI00983100   
Protein Interaction databases
DIP (DOE-UCLA)Q14117
IntAct (EBI)Q14117
FunCoupENSG00000147647
BioGRIDDPYS
STRING (EMBL)DPYS
ZODIACDPYS
Ontologies - Pathways
QuickGOQ14117
Ontology : AmiGOuracil binding  thymine binding  dihydropyrimidinase activity  dihydropyrimidinase activity  dihydropyrimidinase activity  cytosol  cytosol  cytosol  pyrimidine nucleobase catabolic process  pyrimidine nucleobase catabolic process  thymine catabolic process  uracil catabolic process  uracil catabolic process  zinc ion binding  amino acid binding  beta-alanine metabolic process  pyrimidine nucleoside catabolic process  phosphoprotein binding  protein homotetramerization  extracellular exosome  
Ontology : EGO-EBIuracil binding  thymine binding  dihydropyrimidinase activity  dihydropyrimidinase activity  dihydropyrimidinase activity  cytosol  cytosol  cytosol  pyrimidine nucleobase catabolic process  pyrimidine nucleobase catabolic process  thymine catabolic process  uracil catabolic process  uracil catabolic process  zinc ion binding  amino acid binding  beta-alanine metabolic process  pyrimidine nucleoside catabolic process  phosphoprotein binding  protein homotetramerization  extracellular exosome  
Pathways : KEGGPyrimidine metabolism    beta-Alanine metabolism    Pantothenate and CoA biosynthesis    Drug metabolism - other enzymes   
NDEx NetworkDPYS
Atlas of Cancer Signalling NetworkDPYS
Wikipedia pathwaysDPYS
Orthology - Evolution
OrthoDB1807
GeneTree (enSembl)ENSG00000147647
Phylogenetic Trees/Animal Genes : TreeFamDPYS
HOGENOMQ14117
Homologs : HomoloGeneDPYS
Homology/Alignments : Family Browser (UCSC)DPYS
Gene fusions - Rearrangements
Fusion : MitelmanVPS13B/DPYS [8q22.2/8q22.3]  [t(8;8)(q22;q22)]  
Fusion PortalVPS13B 8q22.2 DPYS 8q22.3 LUSC
Fusion : QuiverDPYS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDPYS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DPYS
dbVarDPYS
ClinVarDPYS
1000_GenomesDPYS 
Exome Variant ServerDPYS
ExAC (Exome Aggregation Consortium)ENSG00000147647
GNOMAD BrowserENSG00000147647
Varsome BrowserDPYS
Genetic variants : HAPMAP1807
Genomic Variants (DGV)DPYS [DGVbeta]
DECIPHERDPYS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDPYS 
Mutations
ICGC Data PortalDPYS 
TCGA Data PortalDPYS 
Broad Tumor PortalDPYS
OASIS PortalDPYS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDPYS  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDPYS
Mutations and Diseases : HGMDDPYS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DPYS
DgiDB (Drug Gene Interaction Database)DPYS
DoCM (Curated mutations)DPYS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DPYS (select a term)
intoGenDPYS
Cancer3DDPYS(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM222748    613326   
Orphanet10451   
DisGeNETDPYS
MedgenDPYS
Genetic Testing Registry DPYS
NextProtQ14117 [Medical]
TSGene1807
GENETestsDPYS
Target ValidationDPYS
Huge Navigator DPYS [HugePedia]
snp3D : Map Gene to Disease1807
BioCentury BCIQDPYS
ClinGenDPYS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1807
Chemical/Pharm GKB GenePA146
Clinical trialDPYS
Miscellaneous
canSAR (ICR)DPYS (select the gene name)
DataMed IndexDPYS
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDPYS
EVEXDPYS
GoPubMedDPYS
iHOPDPYS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:41:00 CET 2019
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