DPYSL3 (dihydropyrimidinase like 3)

2007-02-01  

Identity

HGNC
LOCATION
5q32
LOCUSID
ALIAS
CRMP-4,CRMP4,DRP-3,DRP3,LCRMP,ULIP,ULIP-1
FUSION GENES

Other Information

Locus ID:

NCBI: 1809
MIM: 601168
HGNC: 3015
Ensembl: ENSG00000113657

Variants:

dbSNP: 1809
ClinVar: 1809
TCGA: ENSG00000113657
COSMIC: DPYSL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113657ENST00000343218Q14195
ENSG00000113657ENST00000343218A0A140VK07
ENSG00000113657ENST00000398514Q14195
ENSG00000113657ENST00000512722D6RF19
ENSG00000113657ENST00000520473H0YBT4
ENSG00000113657ENST00000523458H0YB87

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
CRMPs in Sema3A signalingREACTOMER-HSA-399956

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
166116312006Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo.71
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
205438702010Expression profiling identifies new function of collapsin response mediator protein 4 as a metastasis-suppressor in prostate cancer.32
243398672013Quantitative proteomic profiling identifies DPYSL3 as pancreatic ductal adenocarcinoma-associated molecule that regulates cell adhesion and migration by stabilization of focal adhesion complex.18
250964022014Dihydropyrimidinase-like 3 facilitates malignant behavior of gastric cancer.17
117717642001Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down syndrome brain.16
211795452010GSK3 regulates mitotic chromosomal alignment through CRMP4.13
251734472015Dihydropyrimidinase-like 3 is a putative hepatocellular carcinoma tumor suppressor.12
228058642013Collapsin response mediator protein 4 expression is associated with liver metastasis and poor survival in pancreatic cancer.11
304980312018DPYSL3 modulates mitosis, migration, and epithelial-to-mesenchymal transition in claudin-low breast cancer.10

Citation

Dessen P

DPYSL3 (dihydropyrimidinase like 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45599/dpysl3