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DR1 (down-regulator of transcription 1)

Identity

Alias_namesdown-regulator of transcription 1, TBP-binding (negative cofactor 2)
Alias_symbol (synonym)NC2-BETA
NC2B
NCB2
Other aliasNC2
HGNC (Hugo) DR1
LocusID (NCBI) 1810
Atlas_Id 56578
Location 1p22.1  [Link to chromosome band 1p22]
Location_base_pair Starts at 93345921 and ends at 93362591 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DR1   3017
Cards
Entrez_Gene (NCBI)DR1  1810  down-regulator of transcription 1
AliasesNC2; NC2-BETA; NC2B; NCB2
GeneCards (Weizmann)DR1
Ensembl hg19 (Hinxton)ENSG00000117505 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000117505 [Gene_View]  ENSG00000117505 [Sequence]  chr1:93345921-93362591 [Contig_View]  DR1 [Vega]
ICGC DataPortalENSG00000117505
TCGA cBioPortalDR1
AceView (NCBI)DR1
Genatlas (Paris)DR1
WikiGenes1810
SOURCE (Princeton)DR1
Genetics Home Reference (NIH)DR1
Genomic and cartography
GoldenPath hg38 (UCSC)DR1  -     chr1:93345921-93362591 +  1p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DR1  -     1p22.1   [Description]    (hg19-Feb_2009)
GoldenPathDR1 - 1p22.1 [CytoView hg19]  DR1 - 1p22.1 [CytoView hg38]
ImmunoBaseENSG00000117505
Mapping of homologs : NCBIDR1 [Mapview hg19]  DR1 [Mapview hg38]
OMIM601482   
Gene and transcription
Genbank (Entrez)AK057541 AK223442 AK311288 AL137673 AL833729
RefSeq transcript (Entrez)NM_001938
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DR1
Cluster EST : UnigeneHs.348418 [ NCBI ]
CGAP (NCI)Hs.348418
Alternative Splicing GalleryENSG00000117505
Gene ExpressionDR1 [ NCBI-GEO ]   DR1 [ EBI - ARRAY_EXPRESS ]   DR1 [ SEEK ]   DR1 [ MEM ]
Gene Expression Viewer (FireBrowse)DR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1810
GTEX Portal (Tissue expression)DR1
Human Protein AtlasENSG00000117505-DR1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ01658   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ01658  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ01658
Splice isoforms : SwissVarQ01658
PhosPhoSitePlusQ01658
Domains : Interpro (EBI)CBFA_NFYB_domain    Histone-fold   
Domain families : Pfam (Sanger)CBFD_NFYB_HMF (PF00808)   
Domain families : Pfam (NCBI)pfam00808   
Conserved Domain (NCBI)DR1
DMDM Disease mutations1810
Blocks (Seattle)DR1
PDB (RSDB)1JFI   
PDB Europe1JFI   
PDB (PDBSum)1JFI   
PDB (IMB)1JFI   
Structural Biology KnowledgeBase1JFI   
SCOP (Structural Classification of Proteins)1JFI   
CATH (Classification of proteins structures)1JFI   
SuperfamilyQ01658
Human Protein Atlas [tissue]ENSG00000117505-DR1 [tissue]
Peptide AtlasQ01658
HPRD03284
IPIIPI00008991   
Protein Interaction databases
DIP (DOE-UCLA)Q01658
IntAct (EBI)Q01658
FunCoupENSG00000117505
BioGRIDDR1
STRING (EMBL)DR1
ZODIACDR1
Ontologies - Pathways
QuickGOQ01658
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  DNA-binding transcription factor activity, RNA polymerase II-specific  core promoter binding  DNA binding  transcription coactivator activity  transcription corepressor activity  protein binding  nucleus  Ada2/Gcn5/Ada3 transcription activator complex  Ada2/Gcn5/Ada3 transcription activator complex  chromatin remodeling  transcription factor binding  TBP-class protein binding  TBP-class protein binding  negative cofactor 2 complex  histone H3 acetylation  regulation of RNA polymerase II transcriptional preinitiation complex assembly  positive regulation of transcription by RNA polymerase II  protein heterodimerization activity  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  DNA-binding transcription factor activity, RNA polymerase II-specific  core promoter binding  DNA binding  transcription coactivator activity  transcription corepressor activity  protein binding  nucleus  Ada2/Gcn5/Ada3 transcription activator complex  Ada2/Gcn5/Ada3 transcription activator complex  chromatin remodeling  transcription factor binding  TBP-class protein binding  TBP-class protein binding  negative cofactor 2 complex  histone H3 acetylation  regulation of RNA polymerase II transcriptional preinitiation complex assembly  positive regulation of transcription by RNA polymerase II  protein heterodimerization activity  
NDEx NetworkDR1
Atlas of Cancer Signalling NetworkDR1
Wikipedia pathwaysDR1
Orthology - Evolution
OrthoDB1810
GeneTree (enSembl)ENSG00000117505
Phylogenetic Trees/Animal Genes : TreeFamDR1
HOGENOMQ01658
Homologs : HomoloGeneDR1
Homology/Alignments : Family Browser (UCSC)DR1
Gene fusions - Rearrangements
Fusion : QuiverDR1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DR1
dbVarDR1
ClinVarDR1
1000_GenomesDR1 
Exome Variant ServerDR1
ExAC (Exome Aggregation Consortium)ENSG00000117505
GNOMAD BrowserENSG00000117505
Varsome BrowserDR1
Genetic variants : HAPMAP1810
Genomic Variants (DGV)DR1 [DGVbeta]
DECIPHERDR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDR1 
Mutations
ICGC Data PortalDR1 
TCGA Data PortalDR1 
Broad Tumor PortalDR1
OASIS PortalDR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDR1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDR1
Mutations and Diseases : HGMDDR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DR1
DgiDB (Drug Gene Interaction Database)DR1
DoCM (Curated mutations)DR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DR1 (select a term)
intoGenDR1
Cancer3DDR1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601482   
Orphanet
DisGeNETDR1
MedgenDR1
Genetic Testing Registry DR1
NextProtQ01658 [Medical]
TSGene1810
GENETestsDR1
Target ValidationDR1
Huge Navigator DR1 [HugePedia]
snp3D : Map Gene to Disease1810
BioCentury BCIQDR1
ClinGenDR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1810
Chemical/Pharm GKB GenePA27475
Clinical trialDR1
Miscellaneous
canSAR (ICR)DR1 (select the gene name)
DataMed IndexDR1
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDR1
EVEXDR1
GoPubMedDR1
iHOPDR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:41:01 CET 2019
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