Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DRAM2 (DNA damage regulated autophagy modulator 2)

Identity

Alias_namesTMEM77
transmembrane protein 77
DNA-damage regulated autophagy modulator 2
Alias_symbol (synonym)MGC54289
PRO180
WWFQ154
RP5-1180E21.1
Other aliasCORD21
HGNC (Hugo) DRAM2
LocusID (NCBI) 128338
Atlas_Id 51330
Location 1p13.3  [Link to chromosome band 1p13]
Location_base_pair Starts at 111117170 and ends at 111140216 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DRAM2   28769
Cards
Entrez_Gene (NCBI)DRAM2  128338  DNA damage regulated autophagy modulator 2
AliasesCORD21; PRO180; TMEM77; WWFQ154
GeneCards (Weizmann)DRAM2
Ensembl hg19 (Hinxton)ENSG00000156171 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000156171 [Gene_View]  ENSG00000156171 [Sequence]  chr1:111117170-111140216 [Contig_View]  DRAM2 [Vega]
ICGC DataPortalENSG00000156171
TCGA cBioPortalDRAM2
AceView (NCBI)DRAM2
Genatlas (Paris)DRAM2
WikiGenes128338
SOURCE (Princeton)DRAM2
Genetics Home Reference (NIH)DRAM2
Genomic and cartography
GoldenPath hg38 (UCSC)DRAM2  -     chr1:111117170-111140216 -  1p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DRAM2  -     1p13.3   [Description]    (hg19-Feb_2009)
GoldenPathDRAM2 - 1p13.3 [CytoView hg19]  DRAM2 - 1p13.3 [CytoView hg38]
ImmunoBaseENSG00000156171
Mapping of homologs : NCBIDRAM2 [Mapview hg19]  DRAM2 [Mapview hg38]
OMIM613360   616502   
Gene and transcription
Genbank (Entrez)AK075350 AK309557 AL833098 AY336747 AY358492
RefSeq transcript (Entrez)NM_001349881 NM_001349882 NM_001349884 NM_001349885 NM_001349886 NM_001349887 NM_001349888 NM_001349889 NM_001349890 NM_001349891 NM_001349892 NM_001349893 NM_178454
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DRAM2
Cluster EST : UnigeneHs.485606 [ NCBI ]
CGAP (NCI)Hs.485606
Alternative Splicing GalleryENSG00000156171
Gene ExpressionDRAM2 [ NCBI-GEO ]   DRAM2 [ EBI - ARRAY_EXPRESS ]   DRAM2 [ SEEK ]   DRAM2 [ MEM ]
Gene Expression Viewer (FireBrowse)DRAM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)128338
GTEX Portal (Tissue expression)DRAM2
Human Protein AtlasENSG00000156171-DRAM2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6UX65   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6UX65  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6UX65
Splice isoforms : SwissVarQ6UX65
PhosPhoSitePlusQ6UX65
Domains : Interpro (EBI)DRAM2    Frag1/DRAM/Sfk1   
Domain families : Pfam (Sanger)Frag1 (PF10277)   
Domain families : Pfam (NCBI)pfam10277   
Conserved Domain (NCBI)DRAM2
DMDM Disease mutations128338
Blocks (Seattle)DRAM2
SuperfamilyQ6UX65
Human Protein Atlas [tissue]ENSG00000156171-DRAM2 [tissue]
Peptide AtlasQ6UX65
HPRD14685
IPIIPI00384306   
Protein Interaction databases
DIP (DOE-UCLA)Q6UX65
IntAct (EBI)Q6UX65
FunCoupENSG00000156171
BioGRIDDRAM2
STRING (EMBL)DRAM2
ZODIACDRAM2
Ontologies - Pathways
QuickGOQ6UX65
Ontology : AmiGOphotoreceptor inner segment  cytoplasm  lysosome  lysosome  lysosomal membrane  Golgi apparatus  autophagy  apoptotic process  visual perception  regulation of autophagy  regulation of autophagy  integral component of membrane  apical plasma membrane  intracellular membrane-bounded organelle  photoreceptor cell maintenance  
Ontology : EGO-EBIphotoreceptor inner segment  cytoplasm  lysosome  lysosome  lysosomal membrane  Golgi apparatus  autophagy  apoptotic process  visual perception  regulation of autophagy  regulation of autophagy  integral component of membrane  apical plasma membrane  intracellular membrane-bounded organelle  photoreceptor cell maintenance  
NDEx NetworkDRAM2
Atlas of Cancer Signalling NetworkDRAM2
Wikipedia pathwaysDRAM2
Orthology - Evolution
OrthoDB128338
GeneTree (enSembl)ENSG00000156171
Phylogenetic Trees/Animal Genes : TreeFamDRAM2
HOGENOMQ6UX65
Homologs : HomoloGeneDRAM2
Homology/Alignments : Family Browser (UCSC)DRAM2
Gene fusions - Rearrangements
Fusion : QuiverDRAM2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDRAM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DRAM2
dbVarDRAM2
ClinVarDRAM2
1000_GenomesDRAM2 
Exome Variant ServerDRAM2
ExAC (Exome Aggregation Consortium)ENSG00000156171
GNOMAD BrowserENSG00000156171
Varsome BrowserDRAM2
Genetic variants : HAPMAP128338
Genomic Variants (DGV)DRAM2 [DGVbeta]
DECIPHERDRAM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDRAM2 
Mutations
ICGC Data PortalDRAM2 
TCGA Data PortalDRAM2 
Broad Tumor PortalDRAM2
OASIS PortalDRAM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDRAM2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDRAM2
Mutations and Diseases : HGMDDRAM2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DRAM2
DgiDB (Drug Gene Interaction Database)DRAM2
DoCM (Curated mutations)DRAM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DRAM2 (select a term)
intoGenDRAM2
Cancer3DDRAM2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613360    616502   
Orphanet1843   
DisGeNETDRAM2
MedgenDRAM2
Genetic Testing Registry DRAM2
NextProtQ6UX65 [Medical]
TSGene128338
GENETestsDRAM2
Target ValidationDRAM2
Huge Navigator DRAM2 [HugePedia]
snp3D : Map Gene to Disease128338
BioCentury BCIQDRAM2
ClinGenDRAM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD128338
Chemical/Pharm GKB GenePA165751270
Clinical trialDRAM2
Miscellaneous
canSAR (ICR)DRAM2 (select the gene name)
DataMed IndexDRAM2
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDRAM2
EVEXDRAM2
GoPubMedDRAM2
iHOPDRAM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:41:01 CET 2019
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