DRD2 (dopamine receptor D2)

2007-02-01  

Identity

HGNC
LOCATION
11q23.2
LOCUSID
ALIAS
D2DR,D2R

Other Information

Locus ID:

NCBI: 1813
MIM: 126450
HGNC: 3023
Ensembl: ENSG00000149295

Variants:

dbSNP: 1813
ClinVar: 1813
TCGA: ENSG00000149295
COSMIC: DRD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149295ENST00000346454P14416
ENSG00000149295ENST00000346454A0A024R3I6
ENSG00000149295ENST00000362072P14416
ENSG00000149295ENST00000362072A0A024R3C5
ENSG00000149295ENST00000538967P14416
ENSG00000149295ENST00000542616A0A1Y8EK52
ENSG00000149295ENST00000542968P14416
ENSG00000149295ENST00000542968A0A024R3C5
ENSG00000149295ENST00000543292Q6LDH7
ENSG00000149295ENST00000544518F8VUV1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Gap junctionKEGGko04540
Neuroactive ligand-receptor interactionKEGGhsa04080
Gap junctionKEGGhsa04540
Parkinson's diseaseKEGGhsa05012
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Dopamine receptorsREACTOMER-HSA-390651
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10026aripiprazoleChemicalClinicalAnnotation, VipGeneassociatedPD11505224, 11920858, 14610521, 15567074, 15694263, 15830237, 16123753, 16513877, 16973280, 17087792, 17105675, 18583979, 18687376, 18926547, 19158809, 19582781, 19900188, 9713903, 9858029, 991813, 10327430, 11505224, 15694263, 15830237, 16513877, 17105675, 18926547, 20194480, 28673279, 9858029, 9918131
PA128406954Weight gainDiseaseClinicalAnnotationassociatedPD17767146, 18086475, 18180754, 18579277, 20714340, 23851570, 23859574, 26872113
PA151186253nemonaprideChemicalClinicalAnnotation, VipGeneassociatedPD10823405, 10862524, 11329406, 11505224, 12587665, 15077009, 15146457, 15184239, 15286066, 15492764, 15830237, 17767146, 17989061, 18086475, 18180754, 18354387, 1839129, 18781856, 18781857, 18855532, 18926547, 19179847, 19273465, 19373123, 19396436, 19603545, 1969501, 19853839, 19944883, 9672901, 10395223, 11505224, 15694263, 15830237, 16513877, 17105675, 18926547, 20194480, 28673279, 9858029, 9918131
PA162565877amisulprideChemicalClinicalAnnotationassociatedPD25679126
PA164712362AnalgesicsChemicalClinicalAnnotationassociated25096645
PA164712462Antiinflammatory agents, non-steroidsChemicalClinicalAnnotationassociated25096645
PA164712741Ergot alkaloidsChemicalClinicalAnnotationassociated25096645
PA164713257Selective serotonin reuptake inhibitorsChemicalClinicalAnnotationassociatedPD22796099
PA164749035ropiniroleChemicalVipGeneassociated18808942
PA164764584rasagilineChemicalClinicalAnnotationassociatedPD27190009
PA165282097bromperidolChemicalClinicalAnnotation, VipGeneassociatedPD11505224, 15694263, 15830237, 16513877, 17105675, 18926547, 20194480, 28673279, 9858029, 9918131
PA166123368schizoaffective disorderDiseaseClinicalAnnotationassociatedPD
PA166154261rs6277VariantVipGeneassociated16123753, 16973280, 17087792, 18583979, 18687376, 18926547, 19158809, 19582781, 19900188, 15567074
PA166154334rs1799732VariantVipGeneassociated11920858, 14610521, 15694263, 15830237, 16123753, 16513877, 17105675, 18926547, 9713903, 9858029, 991813, 11505224
PA166154339rs1800497VariantVipGeneassociated10823405, 10862524, 11329406, 12587665, 15077009, 15146457, 15184239, 15286066, 15492764, 15830237, 17767146, 17989061, 18086475, 18180754, 18354387, 1839129, 18781856, 18781857, 18855532, 18926547, 19179847, 19273465, 19373123, 19396436, 19603545, 1969501, 19853839, 19944883, 9672901, 10395223
PA166154341rs1801028VariantVipGeneassociated12707934, 7907680, 7909081, 8723039, 8824240, 9650635, 11011590
PA443309AlcoholismDiseaseClinicalAnnotationassociatedPD10490697, 11054774, 17989061, 1839129, 1969501, 1979357, 27447243, 29236941, 8033754
PA443842DeathDiseaseClinicalAnnotationassociatedPD29236941
PA444460Heroin DependenceDiseaseClinicalAnnotationassociatedPKPD19373123, 21902500, 23651024
PA444545HyperprolactinemiaDiseaseClinicalAnnotationassociatedPD17767146, 18086475, 18180754, 18579277, 20714340, 23851570, 23859574, 26872113
PA445043Opioid-Related DisordersDiseaseClinicalAnnotationassociatedPD11054774, 19373123, 23651024, 25500252
PA445048NauseaDiseaseClinicalAnnotationassociatedPD24360851
PA445254Parkinson DiseaseDiseaseClinicalAnnotation, VipGeneassociatedPD9457173, 16485914, 27190009, 27779245
PA445452Psychomotor AgitationDiseaseClinicalAnnotationassociatedPD
PA445876Tobacco Use DisorderDiseaseClinicalAnnotation, VipGeneassociatedPD15203796, 16123753
PA446876Substance-Related DisordersDiseaseClinicalAnnotationassociatedPD18687376, 25556837, 8033754
PA446878Cocaine-Related DisordersDiseaseClinicalAnnotationassociatedPD23635803
PA447197Attention Deficit Disorder with HyperactivityDiseaseClinicalAnnotationassociatedPD26810137
PA447199Bipolar DisorderDiseaseClinicalAnnotationassociatedPK21095016
PA447208Mental DisordersDiseaseClinicalAnnotationassociatedPD22967772
PA447215Psychotic DisordersDiseaseClinicalAnnotationassociatedPD18086475, 18579277, 20664489, 21749219, 27272046
PA447216SchizophreniaDiseaseClinicalAnnotation, VipGeneassociatedPD16973280, 17087792, 18583979, 19158809, 8723039, 9097961, 9209827, 11505224, 12707934, 15694263, 15830237, 16513877, 17105675, 18855532, 18926547, 20194480, 20375926, 20714340, 25563748, 25679126, 28673279, 9858029, 9918131
PA447268tardive dyskinesiaDiseaseClinicalAnnotationassociatedPD17767146, 18086475, 18180754, 18579277, 20714340, 23851570, 23859574, 26872113
PA447278DepressionDiseaseClinicalAnnotationassociatedPK21095016
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD22796099
PA448073ethanolChemicalClinicalAnnotationassociatedPD10490697, 11054774, 17989061, 1839129, 1969501, 1979357, 22798433, 27447243, 29236941, 8033754
PA448408amphetamineChemicalClinicalAnnotationassociatedPD
PA448687bupropionChemicalClinicalAnnotation, VipGeneassociatedPD10823405, 10862524, 11329406, 12587665, 15077009, 15146457, 15184239, 15286066, 15492764, 15830237, 17767146, 17989061, 18086475, 18180754, 18354387, 1839129, 18781856, 18781857, 18855532, 18926547, 19179847, 19273465, 19373123, 19396436, 19603545, 1969501, 19853839, 19944883, 9672901, 10395223, 16123753
PA448708cabergolineChemicalVipGeneassociated18808942
PA448964chlorpromazineChemicalClinicalAnnotation, VipGeneassociatedPD11505224, 15694263, 15830237, 16513877, 17105675, 18926547, 20194480, 28673279, 9858029, 9918131
PA449061clozapineChemicalClinicalAnnotation, VipGeneassociatedPD11920858, 14610521, 15694263, 15830237, 16123753, 16513877, 17105675, 18926547, 9713903, 9858029, 991813, 11505224, 15694263, 15830237, 16513877, 17105675, 17767146, 18086475, 18180754, 18579277, 18926547, 20194480, 20375926, 20714340, 23851570, 23859574, 26872113, 28673279, 9858029, 9918131
PA449072cocaineChemicalClinicalAnnotationassociatedPD
PA449376disulfiramChemicalClinicalAnnotationassociatedPD23635803
PA449841haloperidolChemicalMultilinkAnnotation, VipGeneassociated10823405, 10862524, 11329406, 12587665, 15077009, 15146457, 15184239, 15286066, 15492764, 15830237, 17767146, 17989061, 18086475, 18180754, 18354387, 1839129, 18781856, 18781857, 18855532, 18926547, 19179847, 19273465, 19373123, 19396436, 19603545, 1969501, 19853839, 19944883, 9672901, 10395223, 27023437
PA450213levodopaChemicalClinicalAnnotationassociatedPD27779245
PA450401methadoneChemicalClinicalAnnotationassociatedPKPD18687376, 19373123, 21902500, 23651024, 25556837
PA450464methylphenidateChemicalClinicalAnnotationassociatedPD26810137
PA450626nicotineChemicalClinicalAnnotationassociatedPD15203796, 16123753
PA450688olanzapineChemicalClinicalAnnotation, VipGeneassociatedPKPD11920858, 14610521, 15694263, 15830237, 16123753, 16513877, 17105675, 18926547, 9713903, 9858029, 991813, 11505224, 15694263, 15830237, 16513877, 17105675, 17767146, 18086475, 18180754, 18579277, 18926547, 20194480, 20375926, 20714340, 21095016, 22967772, 23851570, 23859574, 25563748, 26872113, 28673279, 9858029, 9918131
PA450873pergolideChemicalVipGeneassociated18808942
PA451114prochlorperazineChemicalClinicalAnnotationassociatedPD24360851
PA451257risperidoneChemicalClinicalAnnotation, VipGeneassociatedPD10823405, 10862524, 11329406, 11505224, 11920858, 12587665, 14610521, 15077009, 15146457, 15184239, 15286066, 15492764, 15694263, 15830237, 16123753, 16513877, 17105675, 17767146, 17989061, 18086475, 18180754, 18354387, 1839129, 18781856, 18781857, 18855532, 18926547, 19179847, 19273465, 19373123, 19396436, 19603545, 1969501, 19853839, 19944883, 9672901, 9713903, 9858029, 991813, 10395223, 11505224, 15694263, 15830237, 16513877, 17105675, 17767146, 18086475, 18180754, 18579277, 18855532, 18926547, 20194480, 20375926, 20714340, 23851570, 23859574, 26872113, 28673279, 9858029, 9918131
PA451566sumatriptanChemicalClinicalAnnotationassociated25096645
PA452233antipsychoticsChemicalClinicalAnnotation, VipGeneassociatedPD11505224, 15694263, 15830237, 16513877, 17105675, 17767146, 18086475, 18180754, 18579277, 18926547, 20194480, 20664489, 20714340, 21749219, 23851570, 23859574, 26872113, 27272046, 28673279, 9209827, 9858029, 9918131
PA452618opioidsChemicalClinicalAnnotationassociatedPD11054774, 19373123, 25096645, 25500252
PA452619heroinChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
185839792008Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.395
189273952008Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele.297
189273952008Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele.297
195069062009Candidate gene studies of ADHD: a meta-analytic review.263
185987722008Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: possible contributing factors.185
180638002007Genetically determined differences in learning from errors.158
178937062009Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity.157
180773732007Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory.154
180773732007Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory.154
151594032004Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal.140

Citation

Dessen P

DRD2 (dopamine receptor D2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46193/drd2