DROSHA (drosha ribonuclease III)

2010-11-01  

Identity

HGNC
LOCATION
5p13.3
LOCUSID
ALIAS
ETOHI2,HSA242976,RANSE3L,RN3,RNASE3L,RNASEN
FUSION GENES

Other Information

Locus ID:

NCBI: 29102
MIM: 608828
HGNC: 17904
Ensembl: ENSG00000113360

Variants:

dbSNP: 29102
ClinVar: 29102
TCGA: ENSG00000113360
COSMIC: DROSHA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113360ENST00000344624Q9NRR4
ENSG00000113360ENST00000442743Q9NRR4
ENSG00000113360ENST00000507438E5RHD1
ENSG00000113360ENST00000511367Q9NRR4
ENSG00000113360ENST00000512076H7C5U6
ENSG00000113360ENST00000512302H0YB67
ENSG00000113360ENST00000513349Q9NRR4

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Ribosome biogenesis in eukaryotesKEGGko03008
Ribosome biogenesis in eukaryotesKEGGhsa03008
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Gene ExpressionREACTOMER-HSA-74160
Gene Silencing by RNAREACTOMER-HSA-211000
MicroRNA (miRNA) biogenesisREACTOMER-HSA-203927

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA446155Precursor Cell Lymphoblastic Leukemia-LymphomaDiseaseClinicalAnnotationassociatedPD24614921
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD24614921
PA449177cytarabineChemicalClinicalAnnotationassociatedPD24614921
PA449212daunorubicinChemicalClinicalAnnotationassociatedPD24614921
PA450379mercaptopurineChemicalClinicalAnnotationassociatedPD24614921
PA450428methotrexateChemicalClinicalAnnotationassociatedPD24614921
PA451100prednisoneChemicalClinicalAnnotationassociatedPD24614921
PA451879vincristineChemicalClinicalAnnotationassociatedPD24614921

References

Pubmed IDYearTitleCitations
145084932003The nuclear RNase III Drosha initiates microRNA processing.1662
155318772004The Microprocessor complex mediates the genesis of microRNAs.939
155745892004The Drosha-DGCR8 complex in primary microRNA processing.692
172559512007Processing of intronic microRNAs.301
190921502008Dicer, Drosha, and outcomes in patients with ovarian cancer.292
155651682005Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha.211
191358902009Posttranscriptional crossregulation between Drosha and DGCR8.180
207052402010Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha.166
197214322010Schizophrenia is associated with an increase in cortical microRNA biogenesis.155
269766052016Re-evaluation of the roles of DROSHA, Export in 5, and DICER in microRNA biogenesis.112

Citation

Dessen P

DROSHA (drosha ribonuclease III)

Atlas Genet Cytogenet Oncol Haematol. 2010-11-01

Online version: http://atlasgeneticsoncology.org/gene/51768/drosha