Identity
HGNC
LOCATION
6q22.1
LOCUSID
ALIAS
DS-epi1,DSEP,DSEPI,EDSMC2,SART-2,SART2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 29940
MIM: 605942
HGNC: 21144
Ensembl: ENSG00000111817
Variants:
dbSNP: 29940
ClinVar: 29940
TCGA: ENSG00000111817
COSMIC: DSE
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166123407 | abiraterone | Chemical | ClinicalAnnotation | associated | PD | ||
| PA445425 | Prostatic Neoplasms | Disease | ClinicalAnnotation | associated | PD | ||
| PA451096 | prednisolone | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 31972438 | 2020 | Dermatan sulfate epimerase 1 expression and mislocalization may interfere with dermatan sulfate synthesis and breast cancer cell growth. | 6 |
| 31972438 | 2020 | Dermatan sulfate epimerase 1 expression and mislocalization may interfere with dermatan sulfate synthesis and breast cancer cell growth. | 6 |
| 29864158 | 2018 | DSE promotes aggressive glioma cell phenotypes by enhancing HB-EGF/ErbB signaling. | 19 |
| 29976758 | 2018 | Dermatan sulfate epimerase 1 and dermatan 4-O-sulfotransferase 1 form complexes that generate long epimerized 4-O-sulfated blocks. | 17 |
| 29864158 | 2018 | DSE promotes aggressive glioma cell phenotypes by enhancing HB-EGF/ErbB signaling. | 19 |
| 29976758 | 2018 | Dermatan sulfate epimerase 1 and dermatan 4-O-sulfotransferase 1 form complexes that generate long epimerized 4-O-sulfated blocks. | 17 |
| 23704329 | 2013 | Loss of dermatan sulfate epimerase (DSE) function results in musculocontractural Ehlers-Danlos syndrome. | 40 |
| 23704329 | 2013 | Loss of dermatan sulfate epimerase (DSE) function results in musculocontractural Ehlers-Danlos syndrome. | 40 |
| 22350411 | 2012 | Dermatan sulfate is involved in the tumorigenic properties of esophagus squamous cell carcinoma. | 38 |
| 22350411 | 2012 | Dermatan sulfate is involved in the tumorigenic properties of esophagus squamous cell carcinoma. | 38 |
| 19004833 | 2009 | Identification of the active site of DS-epimerase 1 and requirement of N-glycosylation for enzyme function. | 20 |
| 19004833 | 2009 | Identification of the active site of DS-epimerase 1 and requirement of N-glycosylation for enzyme function. | 20 |
Citation
Dessen P
DSE (dermatan sulfate epimerase)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/42204/dse
