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DTD1 (D-aminoacyl-tRNA deacylase 1)

Identity

Alias_namesC20orf88
HARS2
chromosome 20 open reading frame 88
D-tyrosyl-tRNA deacylase 1 homolog (S. cerevisiae)
D-tyrosyl-tRNA deacylase 1
Alias_symbol (synonym)DUEB
MGC119131
MGC41905
bA379J5.3
bA555E18.1
pqn-68
Other aliasDTD
DUE-B
HGNC (Hugo) DTD1
LocusID (NCBI) 92675
Atlas_Id 54267
Location 20p11.23  [Link to chromosome band 20p11]
Location_base_pair Starts at 18587893 and ends at 18763916 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AP1M2 (19p13.2) / DTD1 (20p11.23)COASY (17q21.2) / DTD1 (20p11.23)DSTN (20p12.1) / DTD1 (20p11.23)
DTD1 (20p11.23) / FKBP3 (14q21.2)DTD1 (20p11.23) / PDGFRB (5q32)DTD1 (20p11.23) / PET117 (20p11.23)
DTD1 (20p11.23) / RALGAPA2 (20p11.23)DZANK1 (20p11.23) / DTD1 (20p11.23)FRYL (4p11) / DTD1 (20p11.23)
LINC00493 (20p11.23) / DTD1 (20p11.23)PDGFRB (5q32) / DTD1 (20p11.23)C20orf12 DTD1 20p11.23
DSTN 20p12.1 / DTD1 20p11.23DTD1 20p11.23 / RALGAPA2 20p11.23FRYL 4p11 / DTD1 20p11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(5;20)(q32;p11) DTD1/PDGFRB
t(5;20)(q32;p11) DTD1/PDGFRB
t(5;20)(q32;p11) PDGFRB/DTD1

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  t(4;20)(p12;p11) FRYL/DTD1
DTD1/RALGAPA2 (20p11)
DZANK1/DTD1 (20p11)
t(20;20)(p11;p12) DSTN/DTD1
t(20;20)(p11;p12) RRBP1/DTD1

External links

Nomenclature
HGNC (Hugo)DTD1   16219
Cards
Entrez_Gene (NCBI)DTD1  92675  D-aminoacyl-tRNA deacylase 1
AliasesC20orf88; DTD; DUE-B; DUEB; 
HARS2; pqn-68
GeneCards (Weizmann)DTD1
Ensembl hg19 (Hinxton)ENSG00000125821 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125821 [Gene_View]  ENSG00000125821 [Sequence]  chr20:18587893-18763916 [Contig_View]  DTD1 [Vega]
ICGC DataPortalENSG00000125821
TCGA cBioPortalDTD1
AceView (NCBI)DTD1
Genatlas (Paris)DTD1
WikiGenes92675
SOURCE (Princeton)DTD1
Genetics Home Reference (NIH)DTD1
Genomic and cartography
GoldenPath hg38 (UCSC)DTD1  -     chr20:18587893-18763916 +  20p11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DTD1  -     20p11.23   [Description]    (hg19-Feb_2009)
GoldenPathDTD1 - 20p11.23 [CytoView hg19]  DTD1 - 20p11.23 [CytoView hg38]
ImmunoBaseENSG00000125821
Mapping of homologs : NCBIDTD1 [Mapview hg19]  DTD1 [Mapview hg38]
OMIM610996   
Gene and transcription
Genbank (Entrez)AF332356 AK074304 AK291440 AW022517 BC000599
RefSeq transcript (Entrez)NM_001318043 NM_080820
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DTD1
Cluster EST : UnigeneHs.659442 [ NCBI ]
CGAP (NCI)Hs.659442
Alternative Splicing GalleryENSG00000125821
Gene ExpressionDTD1 [ NCBI-GEO ]   DTD1 [ EBI - ARRAY_EXPRESS ]   DTD1 [ SEEK ]   DTD1 [ MEM ]
Gene Expression Viewer (FireBrowse)DTD1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)92675
GTEX Portal (Tissue expression)DTD1
Human Protein AtlasENSG00000125821-DTD1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TEA8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TEA8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TEA8
Splice isoforms : SwissVarQ8TEA8
Catalytic activity : Enzyme3.1.1.96 [ Enzyme-Expasy ]   3.1.1.963.1.1.96 [ IntEnz-EBI ]   3.1.1.96 [ BRENDA ]   3.1.1.96 [ KEGG ]   
PhosPhoSitePlusQ8TEA8
Domains : Interpro (EBI)Daa-tRNA_deacyls_DTD    DTD-like_sf   
Domain families : Pfam (Sanger)Tyr_Deacylase (PF02580)   
Domain families : Pfam (NCBI)pfam02580   
Conserved Domain (NCBI)DTD1
DMDM Disease mutations92675
Blocks (Seattle)DTD1
PDB (RSDB)2OKV   
PDB Europe2OKV   
PDB (PDBSum)2OKV   
PDB (IMB)2OKV   
Structural Biology KnowledgeBase2OKV   
SCOP (Structural Classification of Proteins)2OKV   
CATH (Classification of proteins structures)2OKV   
SuperfamilyQ8TEA8
Human Protein Atlas [tissue]ENSG00000125821-DTD1 [tissue]
Peptide AtlasQ8TEA8
IPIIPI00152692   
Protein Interaction databases
DIP (DOE-UCLA)Q8TEA8
IntAct (EBI)Q8TEA8
FunCoupENSG00000125821
BioGRIDDTD1
STRING (EMBL)DTD1
ZODIACDTD1
Ontologies - Pathways
QuickGOQ8TEA8
Ontology : AmiGOtRNA binding  aminoacyl-tRNA editing activity  DNA binding  nucleolus  cytoplasm  cytosol  DNA replication  tRNA metabolic process  metal ion binding  D-tyrosyl-tRNA(Tyr) deacylase activity  aminoacyl-tRNA metabolism involved in translational fidelity  
Ontology : EGO-EBItRNA binding  aminoacyl-tRNA editing activity  DNA binding  nucleolus  cytoplasm  cytosol  DNA replication  tRNA metabolic process  metal ion binding  D-tyrosyl-tRNA(Tyr) deacylase activity  aminoacyl-tRNA metabolism involved in translational fidelity  
NDEx NetworkDTD1
Atlas of Cancer Signalling NetworkDTD1
Wikipedia pathwaysDTD1
Orthology - Evolution
OrthoDB92675
GeneTree (enSembl)ENSG00000125821
Phylogenetic Trees/Animal Genes : TreeFamDTD1
HOGENOMQ8TEA8
Homologs : HomoloGeneDTD1
Homology/Alignments : Family Browser (UCSC)DTD1
Gene fusions - Rearrangements
Fusion : MitelmanDSTN/DTD1 [20p12.1/20p11.23]  [t(20;20)(p11;p12)]  
Fusion : MitelmanDTD1/PDGFRB [20p11.23/5q32]  [t(5;20)(q32;p11)]  
Fusion : MitelmanDTD1/RALGAPA2 [20p11.23/20p11.23]  [t(20;20)(p11;p11)]  
Fusion : MitelmanDZANK1/DTD1 [20p11.23/20p11.23]  [t(20;20)(p11;p11)]  
Fusion : MitelmanFRYL/DTD1 [4p11/20p11.23]  [t(4;20)(p12;p11)]  
Fusion : MitelmanPDGFRB/DTD1 [5q32/20p11.23]  [t(5;20)(q32;p11)]  
Fusion PortalC20orf12 DTD1 20p11.23 LUAD
Fusion PortalDSTN 20p12.1 DTD1 20p11.23 PRAD
Fusion PortalDTD1 20p11.23 RALGAPA2 20p11.23 HNSC
Fusion PortalFRYL 4p11 DTD1 20p11.23 BRCA
Fusion : QuiverDTD1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDTD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DTD1
dbVarDTD1
ClinVarDTD1
1000_GenomesDTD1 
Exome Variant ServerDTD1
ExAC (Exome Aggregation Consortium)ENSG00000125821
GNOMAD BrowserENSG00000125821
Varsome BrowserDTD1
Genetic variants : HAPMAP92675
Genomic Variants (DGV)DTD1 [DGVbeta]
DECIPHERDTD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDTD1 
Mutations
ICGC Data PortalDTD1 
TCGA Data PortalDTD1 
Broad Tumor PortalDTD1
OASIS PortalDTD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDTD1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDTD1
Mutations and Diseases : HGMDDTD1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DTD1
DgiDB (Drug Gene Interaction Database)DTD1
DoCM (Curated mutations)DTD1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DTD1 (select a term)
intoGenDTD1
Cancer3DDTD1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610996   
Orphanet
DisGeNETDTD1
MedgenDTD1
Genetic Testing Registry DTD1
NextProtQ8TEA8 [Medical]
TSGene92675
GENETestsDTD1
Target ValidationDTD1
Huge Navigator DTD1 [HugePedia]
snp3D : Map Gene to Disease92675
BioCentury BCIQDTD1
ClinGenDTD1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD92675
Chemical/Pharm GKB GenePA162384107
Clinical trialDTD1
Miscellaneous
canSAR (ICR)DTD1 (select the gene name)
DataMed IndexDTD1
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDTD1
EVEXDTD1
GoPubMedDTD1
iHOPDTD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:41:07 CET 2019
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