DTX1 (deltex E3 ubiquitin ligase 1)

2003-11-01  

Identity

HGNC
LOCATION
12q24.13
LOCUSID
ALIAS
RNF140,hDx-1
FUSION GENES

Other Information

Locus ID:

NCBI: 1840
MIM: 602582
HGNC: 3060
Ensembl: ENSG00000135144

Variants:

dbSNP: 1840
ClinVar: 1840
TCGA: ENSG00000135144
COSMIC: DTX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135144ENST00000257600Q86Y01

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Notch signaling pathwayKEGGko04330
Notch signaling pathwayKEGGhsa04330
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
Activated NOTCH1 Transmits Signal to the NucleusREACTOMER-HSA-2122948

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
126709572003The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.40
126179942003Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells.13
281464322017Integrative computational analysis of transcriptional and epigenetic alterations implicates DTX1 as a putative tumor suppressor gene in HNSCC.8
293741802018c-FLIP is a target of the E3 ligase deltex1 in gastric cancer.8
294404322018PI5P4Kγ functions in DTX1-mediated Notch signaling.6
233956802013New partner proteins containing novel internal recognition motif for human glutaminase interacting protein (hGIP).4
268949272016Deltex1 Polymorphisms Are Associated with Hepatitis B Vaccination Non-Response in Southwest China.4
281838502017Deltex-1 mutations predict poor survival in diffuse large B-cell lymphoma.4
297048702018Immune-regulatory genes as possible modifiers of familial pityriasis rubra pilaris - lessons from a family with PRP and psoriasis.1
313130372019Genetic Variant of Notch Regulator DTX1 Predicts Survival After Lung Cancer Surgery.0

Citation

Dessen P

DTX1 (deltex E3 ubiquitin ligase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40370/dtx1