Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DTX3 (deltex E3 ubiquitin ligase 3)

Identity

Alias_namesdeltex 3 homolog (Drosophila)
deltex homolog 3 (Drosophila)
Alias_symbol (synonym)FLJ34766
RNF154
Other aliasdeltex3
HGNC (Hugo) DTX3
LocusID (NCBI) 196403
Atlas_Id 62668
Location 12q13.3  [Link to chromosome band 12q13]
Location_base_pair Starts at 57604622 and ends at 57609804 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FRS2 (12q15) / DTX3 (12q13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DTX3   24457
Cards
Entrez_Gene (NCBI)DTX3  196403  deltex E3 ubiquitin ligase 3
AliasesRNF154; deltex3
GeneCards (Weizmann)DTX3
Ensembl hg19 (Hinxton)ENSG00000178498 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178498 [Gene_View]  ENSG00000178498 [Sequence]  chr12:57604622-57609804 [Contig_View]  DTX3 [Vega]
ICGC DataPortalENSG00000178498
TCGA cBioPortalDTX3
AceView (NCBI)DTX3
Genatlas (Paris)DTX3
WikiGenes196403
SOURCE (Princeton)DTX3
Genetics Home Reference (NIH)DTX3
Genomic and cartography
GoldenPath hg38 (UCSC)DTX3  -     chr12:57604622-57609804 +  12q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DTX3  -     12q13.3   [Description]    (hg19-Feb_2009)
GoldenPathDTX3 - 12q13.3 [CytoView hg19]  DTX3 - 12q13.3 [CytoView hg38]
ImmunoBaseENSG00000178498
Mapping of homologs : NCBIDTX3 [Mapview hg19]  DTX3 [Mapview hg38]
OMIM613142   
Gene and transcription
Genbank (Entrez)AK092085 AK094385 AK128752 AL831941 AY225126
RefSeq transcript (Entrez)NM_001286245 NM_001286246 NM_178502
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DTX3
Cluster EST : UnigeneHs.32374 [ NCBI ]
CGAP (NCI)Hs.32374
Alternative Splicing GalleryENSG00000178498
Gene ExpressionDTX3 [ NCBI-GEO ]   DTX3 [ EBI - ARRAY_EXPRESS ]   DTX3 [ SEEK ]   DTX3 [ MEM ]
Gene Expression Viewer (FireBrowse)DTX3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)196403
GTEX Portal (Tissue expression)DTX3
Human Protein AtlasENSG00000178498-DTX3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N9I9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N9I9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N9I9
Splice isoforms : SwissVarQ8N9I9
PhosPhoSitePlusQ8N9I9
Domaine pattern : Prosite (Expaxy)ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)RING (SM00184)  
Conserved Domain (NCBI)DTX3
DMDM Disease mutations196403
Blocks (Seattle)DTX3
SuperfamilyQ8N9I9
Human Protein Atlas [tissue]ENSG00000178498-DTX3 [tissue]
Peptide AtlasQ8N9I9
HPRD16842
IPIIPI00184064   IPI00148820   IPI01020985   IPI01020708   IPI01022802   IPI01022458   IPI01022623   
Protein Interaction databases
DIP (DOE-UCLA)Q8N9I9
IntAct (EBI)Q8N9I9
FunCoupENSG00000178498
BioGRIDDTX3
STRING (EMBL)DTX3
ZODIACDTX3
Ontologies - Pathways
QuickGOQ8N9I9
Ontology : AmiGOprotein binding  cytoplasm  Notch signaling pathway  protein ubiquitination  transferase activity  metal ion binding  
Ontology : EGO-EBIprotein binding  cytoplasm  Notch signaling pathway  protein ubiquitination  transferase activity  metal ion binding  
Pathways : KEGGNotch signaling pathway   
NDEx NetworkDTX3
Atlas of Cancer Signalling NetworkDTX3
Wikipedia pathwaysDTX3
Orthology - Evolution
OrthoDB196403
GeneTree (enSembl)ENSG00000178498
Phylogenetic Trees/Animal Genes : TreeFamDTX3
HOGENOMQ8N9I9
Homologs : HomoloGeneDTX3
Homology/Alignments : Family Browser (UCSC)DTX3
Gene fusions - Rearrangements
Fusion : QuiverDTX3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDTX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DTX3
dbVarDTX3
ClinVarDTX3
1000_GenomesDTX3 
Exome Variant ServerDTX3
ExAC (Exome Aggregation Consortium)ENSG00000178498
GNOMAD BrowserENSG00000178498
Varsome BrowserDTX3
Genetic variants : HAPMAP196403
Genomic Variants (DGV)DTX3 [DGVbeta]
DECIPHERDTX3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDTX3 
Mutations
ICGC Data PortalDTX3 
TCGA Data PortalDTX3 
Broad Tumor PortalDTX3
OASIS PortalDTX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDTX3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDTX3
Mutations and Diseases : HGMDDTX3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DTX3
DgiDB (Drug Gene Interaction Database)DTX3
DoCM (Curated mutations)DTX3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DTX3 (select a term)
intoGenDTX3
Cancer3DDTX3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613142   
Orphanet
DisGeNETDTX3
MedgenDTX3
Genetic Testing Registry DTX3
NextProtQ8N9I9 [Medical]
TSGene196403
GENETestsDTX3
Target ValidationDTX3
Huge Navigator DTX3 [HugePedia]
snp3D : Map Gene to Disease196403
BioCentury BCIQDTX3
ClinGenDTX3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD196403
Chemical/Pharm GKB GenePA134887936
Clinical trialDTX3
Miscellaneous
canSAR (ICR)DTX3 (select the gene name)
DataMed IndexDTX3
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDTX3
EVEXDTX3
GoPubMedDTX3
iHOPDTX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Sep 3 15:26:18 CEST 2019
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