DTYMK (deoxythymidylate kinase)

2008-07-01  

Identity

HGNC
LOCATION
2q37.3
LOCUSID
ALIAS
CDC8,PP3731,TMPK,TYMK
FUSION GENES

Other Information

Locus ID:

NCBI: 1841
MIM: 188345
HGNC: 3061
Ensembl: ENSG00000168393

Variants:

dbSNP: 1841
ClinVar: 1841
TCGA: ENSG00000168393
COSMIC: DTYMK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168393ENST00000305784P23919
ENSG00000168393ENST00000305784Q6FGU2
ENSG00000168393ENST00000400770G5E9E9
ENSG00000168393ENST00000420144H7BZ20
ENSG00000168393ENST00000432348H7C3A4
ENSG00000168393ENST00000445261H7C312

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Pyrimidine metabolismKEGGko00240
Pyrimidine metabolismKEGGhsa00240
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Synthesis and interconversion of nucleotide di- and triphosphatesREACTOMER-HSA-499943

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA451954zidovudineChemicalPathwayassociated22960662

References

Pubmed IDYearTitleCitations
184137512008Synthetic lethality by lentiviral short hairpin RNA silencing of thymidylate kinase and doxorubicin in colon cancer cells regardless of the p53 status.6
301992842019Thymidylate kinase is critical for DNA repair via ATM-dependent Tip60 complex formation.1
304473762019Insights into product release dynamics through structural analyses of thymidylate kinase.1
312717402019Deoxythymidylate kinase, DTYMK, is a novel gene for mitochondrial DNA depletion syndrome.1

Citation

Dessen P

DTYMK (deoxythymidylate kinase)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50236/dtymk