DUOX1 (dual oxidase 1)

2007-07-01  

Identity

HGNC
LOCATION
15q21.1
LOCUSID
ALIAS
LNOX1,NOXEF1,THOX1

Other Information

Locus ID:

NCBI: 53905
MIM: 606758
HGNC: 3062
Ensembl: ENSG00000137857

Variants:

dbSNP: 53905
ClinVar: 53905
TCGA: ENSG00000137857
COSMIC: DUOX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137857ENST00000321429Q9NRD9
ENSG00000137857ENST00000389037Q9NRD9
ENSG00000137857ENST00000558322H0YNR5
ENSG00000137857ENST00000561166Q9NRD9
ENSG00000137857ENST00000561220H0YK19

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amine-derived hormonesREACTOMER-HSA-209776
Thyroxine biosynthesisREACTOMER-HSA-209968

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
161116802005Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium.108
156777702005Regulated hydrogen peroxide production by Duox in human airway epithelial cells.101
156403472005Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells.83
171352612007Airway epithelial cell migration and wound repair by ATP-mediated activation of dual oxidase 1.70
182814782008Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer.65
197306832009The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.59
191446502009Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation.56
265971622016Airway epithelial dual oxidase 1 mediates allergen-induced IL-33 secretion and activation of type 2 immune responses.48
206829132010The nonphagocytic NADPH oxidase Duox1 mediates a positive feedback loop during T cell receptor signaling.45
258480562015NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation.41

Citation

Dessen P

DUOX1 (dual oxidase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47651/duox1