Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

DUOX2 (dual oxidase 2)

Identity

Alias_symbol (synonym)P138-TOX
P138(TOX)
THOX2
LNOX2
Other aliasNOXEF2
TDH6
HGNC (Hugo) DUOX2
LocusID (NCBI) 50506
Atlas_Id 46154
Location 15q21.1  [Link to chromosome band 15q21]
Location_base_pair Starts at 45092654 and ends at 45114161 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DUOX2 (15q21.1) / ERC2 (3p14.3)DUOX2 (15q21.1) / TAB2 (6q25.1)SDF2L1 (22q11.21) / DUOX2 (15q21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DUOX2   13273
Cards
Entrez_Gene (NCBI)DUOX2  50506  dual oxidase 2
AliasesLNOX2; NOXEF2; P138-TOX; TDH6; 
THOX2
GeneCards (Weizmann)DUOX2
Ensembl hg19 (Hinxton)ENSG00000140279 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140279 [Gene_View]  ENSG00000140279 [Sequence]  chr15:45092654-45114161 [Contig_View]  DUOX2 [Vega]
ICGC DataPortalENSG00000140279
TCGA cBioPortalDUOX2
AceView (NCBI)DUOX2
Genatlas (Paris)DUOX2
WikiGenes50506
SOURCE (Princeton)DUOX2
Genetics Home Reference (NIH)DUOX2
Genomic and cartography
GoldenPath hg38 (UCSC)DUOX2  -     chr15:45092654-45114161 -  15q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DUOX2  -     15q21.1   [Description]    (hg19-Feb_2009)
GoldenPathDUOX2 - 15q21.1 [CytoView hg19]  DUOX2 - 15q21.1 [CytoView hg38]
ImmunoBaseENSG00000140279
Mapping of homologs : NCBIDUOX2 [Mapview hg19]  DUOX2 [Mapview hg38]
OMIM606759   607200   
Gene and transcription
Genbank (Entrez)AB209010 AF181972 AF230496 AF267981 BI045475
RefSeq transcript (Entrez)NM_001363711 NM_014080
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DUOX2
Cluster EST : UnigeneHs.71377 [ NCBI ]
CGAP (NCI)Hs.71377
Alternative Splicing GalleryENSG00000140279
Gene ExpressionDUOX2 [ NCBI-GEO ]   DUOX2 [ EBI - ARRAY_EXPRESS ]   DUOX2 [ SEEK ]   DUOX2 [ MEM ]
Gene Expression Viewer (FireBrowse)DUOX2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)50506
GTEX Portal (Tissue expression)DUOX2
Human Protein AtlasENSG00000140279-DUOX2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NRD8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NRD8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NRD8
Splice isoforms : SwissVarQ9NRD8
PhosPhoSitePlusQ9NRD8
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    FAD_FR (PS51384)    PEROXIDASE_3 (PS50292)   
Domains : Interpro (EBI)DUOX2    DUOX_peroxidase    EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    FAD-bd_8    Fd_Rdtase_FAD-bd    Fe3_Rdtase_TM_dom    Fe_red_NAD-bd_6    Haem_peroxidase    Haem_peroxidase_animal    Haem_peroxidase_sf    Riboflavin_synthase-like_b-brl   
Domain families : Pfam (Sanger)An_peroxidase (PF03098)    EF-hand_1 (PF00036)    FAD_binding_8 (PF08022)    Ferric_reduct (PF01794)    NAD_binding_6 (PF08030)   
Domain families : Pfam (NCBI)pfam03098    pfam00036    pfam08022    pfam01794    pfam08030   
Domain families : Smart (EMBL)EFh (SM00054)  
Conserved Domain (NCBI)DUOX2
DMDM Disease mutations50506
Blocks (Seattle)DUOX2
SuperfamilyQ9NRD8
Human Protein Atlas [tissue]ENSG00000140279-DUOX2 [tissue]
Peptide AtlasQ9NRD8
HPRD05997
IPIIPI00299627   IPI00556311   
Protein Interaction databases
DIP (DOE-UCLA)Q9NRD8
IntAct (EBI)Q9NRD8
FunCoupENSG00000140279
BioGRIDDUOX2
STRING (EMBL)DUOX2
ZODIACDUOX2
Ontologies - Pathways
QuickGOQ9NRD8
Ontology : AmiGOperoxidase activity  calcium ion binding  protein binding  endoplasmic reticulum  cytosol  plasma membrane  plasma membrane  plasma membrane  plasma membrane  thyroid hormone generation  thyroid hormone generation  defense response  response to oxidative stress  response to virus  cell surface  NAD(P)H oxidase activity  NAD(P)H oxidase activity  superoxide-generating NADPH oxidase activity  apical plasma membrane  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  heme binding  cell junction  cell leading edge  cuticle development  hormone biosynthetic process  superoxide anion generation  superoxide anion generation  hydrogen peroxide catabolic process  NADPH oxidase complex  apical part of cell  hydrogen peroxide biosynthetic process  response to cAMP  response to cAMP  oxidation-reduction process  oxidation-reduction process  extracellular exosome  positive regulation of wound healing  cellular oxidant detoxification  positive regulation of cell motility  
Ontology : EGO-EBIperoxidase activity  calcium ion binding  protein binding  endoplasmic reticulum  cytosol  plasma membrane  plasma membrane  plasma membrane  plasma membrane  thyroid hormone generation  thyroid hormone generation  defense response  response to oxidative stress  response to virus  cell surface  NAD(P)H oxidase activity  NAD(P)H oxidase activity  superoxide-generating NADPH oxidase activity  apical plasma membrane  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  heme binding  cell junction  cell leading edge  cuticle development  hormone biosynthetic process  superoxide anion generation  superoxide anion generation  hydrogen peroxide catabolic process  NADPH oxidase complex  apical part of cell  hydrogen peroxide biosynthetic process  response to cAMP  response to cAMP  oxidation-reduction process  oxidation-reduction process  extracellular exosome  positive regulation of wound healing  cellular oxidant detoxification  positive regulation of cell motility  
Pathways : KEGGThyroid hormone synthesis   
NDEx NetworkDUOX2
Atlas of Cancer Signalling NetworkDUOX2
Wikipedia pathwaysDUOX2
Orthology - Evolution
OrthoDB50506
GeneTree (enSembl)ENSG00000140279
Phylogenetic Trees/Animal Genes : TreeFamDUOX2
HOGENOMQ9NRD8
Homologs : HomoloGeneDUOX2
Homology/Alignments : Family Browser (UCSC)DUOX2
Gene fusions - Rearrangements
Fusion : QuiverDUOX2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDUOX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DUOX2
dbVarDUOX2
ClinVarDUOX2
1000_GenomesDUOX2 
Exome Variant ServerDUOX2
ExAC (Exome Aggregation Consortium)ENSG00000140279
GNOMAD BrowserENSG00000140279
Varsome BrowserDUOX2
Genetic variants : HAPMAP50506
Genomic Variants (DGV)DUOX2 [DGVbeta]
DECIPHERDUOX2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDUOX2 
Mutations
ICGC Data PortalDUOX2 
TCGA Data PortalDUOX2 
Broad Tumor PortalDUOX2
OASIS PortalDUOX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDUOX2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDUOX2
Mutations and Diseases : HGMDDUOX2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DUOX2
DgiDB (Drug Gene Interaction Database)DUOX2
DoCM (Curated mutations)DUOX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DUOX2 (select a term)
intoGenDUOX2
Cancer3DDUOX2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606759    607200   
Orphanet19036    12671   
DisGeNETDUOX2
MedgenDUOX2
Genetic Testing Registry DUOX2
NextProtQ9NRD8 [Medical]
TSGene50506
GENETestsDUOX2
Target ValidationDUOX2
Huge Navigator DUOX2 [HugePedia]
snp3D : Map Gene to Disease50506
BioCentury BCIQDUOX2
ClinGenDUOX2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD50506
Chemical/Pharm GKB GenePA27517
Clinical trialDUOX2
Miscellaneous
canSAR (ICR)DUOX2 (select the gene name)
DataMed IndexDUOX2
Probes
Litterature
PubMed104 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDUOX2
EVEXDUOX2
GoPubMedDUOX2
iHOPDUOX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:41:09 CET 2019
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.