DUSP14 (dual specificity phosphatase 14)

2003-05-01  

Identity

HGNC
DUSP14
LOCATION
17q12
LOCUSID
11072
ALIAS
MKP-L,MKP6
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11072
MIM: 606618
HGNC: 17007
Ensembl: ENSG00000276023

Variants:

dbSNP: 11072
ClinVar: 11072
TCGA: ENSG00000276023
COSMIC: DUSP14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000276023ENST00000613659O95147
ENSG00000276023ENST00000613659Q6FI36
ENSG00000276023ENST00000614411O95147
ENSG00000276023ENST00000614411Q6FI36
ENSG00000276023ENST00000617516O95147
ENSG00000276023ENST00000617516Q6FI36

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
222338102012Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection.107
232295442013The dual-specificity phosphatase DUSP14 negatively regulates tumor necrosis factor- and interleukin-1-induced nuclear factor-κB activation by dephosphorylating the protein kinase TAK1.16
197704982009Overproduction, purification and structure determination of human dual-specificity phosphatase 14.12
265210442016TRAF2-mediated Lys63-linked ubiquitination of DUSP14/MKP6 is essential for its phosphatase activity.12
268917232016Dual-specificity phosphatase 14 protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction through inactivation of TAK1-P38MAPK/-JNK1/2 signaling pathway.10
171788442006Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation.9
182015682008Mycobacterial lipomannan induces MAP kinase phosphatase-1 expression in macrophages.4
290772102018Hepatocyte DUSP14 maintains metabolic homeostasis and suppresses inflammation in the liver.3
269386652016Influence of the polymorphism of the DUSP14 gene on the expression of immune-related genes and development of pulmonary tuberculosis.2

Citation

Dessen P

DUSP14 (dual specificity phosphatase 14)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40372/dusp14