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DUSP18 (dual specificity phosphatase 18)

Identity

Alias (NCBI)DSP18
DUSP20
LMWDSP20
HGNC (Hugo) DUSP18
HGNC Alias symbDUSP20
LocusID (NCBI) 150290
Atlas_Id 62676
Location 22q12.2  [Link to chromosome band 22q12]
Location_base_pair Starts at 30661458 and ends at 30667890 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DUSP18   18484
Cards
Entrez_Gene (NCBI)DUSP18  150290  dual specificity phosphatase 18
AliasesDSP18; DUSP20; LMWDSP20
GeneCards (Weizmann)DUSP18
Ensembl hg19 (Hinxton)ENSG00000167065 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167065 [Gene_View]  ENSG00000167065 [Sequence]  chr22:30661458-30667890 [Contig_View]  DUSP18 [Vega]
ICGC DataPortalENSG00000167065
TCGA cBioPortalDUSP18
AceView (NCBI)DUSP18
Genatlas (Paris)DUSP18
WikiGenes150290
SOURCE (Princeton)DUSP18
Genetics Home Reference (NIH)DUSP18
Genomic and cartography
GoldenPath hg38 (UCSC)DUSP18  -     chr22:30661458-30667890 -  22q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DUSP18  -     22q12.2   [Description]    (hg19-Feb_2009)
GoldenPathDUSP18 - 22q12.2 [CytoView hg19]  DUSP18 - 22q12.2 [CytoView hg38]
ImmunoBaseENSG00000167065
genome Data Viewer NCBIDUSP18 [Mapview hg19]  
OMIM611446   
Gene and transcription
Genbank (Entrez)AF461689 AF533017 AI699242 AK025036 AK056074
RefSeq transcript (Entrez)NM_001304794 NM_001304795 NM_001304796 NM_152511
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DUSP18
Alternative Splicing GalleryENSG00000167065
Gene ExpressionDUSP18 [ NCBI-GEO ]   DUSP18 [ EBI - ARRAY_EXPRESS ]   DUSP18 [ SEEK ]   DUSP18 [ MEM ]
Gene Expression Viewer (FireBrowse)DUSP18 [ Firebrowse - Broad ]
GenevisibleExpression of DUSP18 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)150290
GTEX Portal (Tissue expression)DUSP18
Human Protein AtlasENSG00000167065-DUSP18 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NEJ0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NEJ0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NEJ0
Splice isoforms : SwissVarQ8NEJ0
PhosPhoSitePlusQ8NEJ0
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_DUAL (PS50054)   
Domains : Interpro (EBI)Atypical_DUSP    Atypical_DUSP_subfamB    Dual-sp_phosphatase_cat-dom    Prot-tyrosine_phosphatase-like    Tyr_Pase_AS    TYR_PHOSPHATASE_dom    TYR_PHOSPHATASE_DUAL_dom   
Domain families : Pfam (Sanger)DSPc (PF00782)   
Domain families : Pfam (NCBI)pfam00782   
Domain families : Smart (EMBL)DSPc (SM00195)  
Conserved Domain (NCBI)DUSP18
DMDM Disease mutations150290
Blocks (Seattle)DUSP18
PDB (RSDB)2ESB   
PDB Europe2ESB   
PDB (PDBSum)2ESB   
PDB (IMB)2ESB   
Structural Biology KnowledgeBase2ESB   
SCOP (Structural Classification of Proteins)2ESB   
CATH (Classification of proteins structures)2ESB   
SuperfamilyQ8NEJ0
Human Protein Atlas [tissue]ENSG00000167065-DUSP18 [tissue]
Peptide AtlasQ8NEJ0
HPRD13253
IPIIPI00168678   IPI00878881   IPI00879525   IPI00879375   IPI00879942   IPI00879139   
Protein Interaction databases
DIP (DOE-UCLA)Q8NEJ0
IntAct (EBI)Q8NEJ0
FunCoupENSG00000167065
BioGRIDDUSP18
STRING (EMBL)DUSP18
ZODIACDUSP18
Ontologies - Pathways
QuickGOQ8NEJ0
Ontology : AmiGOinactivation of MAPK activity  protein tyrosine phosphatase activity  protein binding  nucleus  nucleoplasm  cytoplasm  mitochondrial inner membrane  protein tyrosine/serine/threonine phosphatase activity  dephosphorylation  phosphatase activity  MAP kinase tyrosine/serine/threonine phosphatase activity  peptidyl-tyrosine dephosphorylation  peptidyl-threonine dephosphorylation  
Ontology : EGO-EBIinactivation of MAPK activity  protein tyrosine phosphatase activity  protein binding  nucleus  nucleoplasm  cytoplasm  mitochondrial inner membrane  protein tyrosine/serine/threonine phosphatase activity  dephosphorylation  phosphatase activity  MAP kinase tyrosine/serine/threonine phosphatase activity  peptidyl-tyrosine dephosphorylation  peptidyl-threonine dephosphorylation  
NDEx NetworkDUSP18
Atlas of Cancer Signalling NetworkDUSP18
Wikipedia pathwaysDUSP18
Orthology - Evolution
OrthoDB150290
GeneTree (enSembl)ENSG00000167065
Phylogenetic Trees/Animal Genes : TreeFamDUSP18
HOGENOMQ8NEJ0
Homologs : HomoloGeneDUSP18
Homology/Alignments : Family Browser (UCSC)DUSP18
Gene fusions - Rearrangements
Fusion : QuiverDUSP18
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDUSP18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DUSP18
dbVarDUSP18
ClinVarDUSP18
1000_GenomesDUSP18 
Exome Variant ServerDUSP18
GNOMAD BrowserENSG00000167065
Varsome BrowserDUSP18
Genetic variants : HAPMAP150290
Genomic Variants (DGV)DUSP18 [DGVbeta]
DECIPHERDUSP18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDUSP18 
Mutations
ICGC Data PortalDUSP18 
TCGA Data PortalDUSP18 
Broad Tumor PortalDUSP18
OASIS PortalDUSP18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDUSP18  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDUSP18
Mutations and Diseases : HGMDDUSP18
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DUSP18
DgiDB (Drug Gene Interaction Database)DUSP18
DoCM (Curated mutations)DUSP18 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DUSP18 (select a term)
intoGenDUSP18
Cancer3DDUSP18(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611446   
Orphanet
DisGeNETDUSP18
MedgenDUSP18
Genetic Testing Registry DUSP18
NextProtQ8NEJ0 [Medical]
TSGene150290
GENETestsDUSP18
Target ValidationDUSP18
Huge Navigator DUSP18 [HugePedia]
snp3D : Map Gene to Disease150290
BioCentury BCIQDUSP18
ClinGenDUSP18
Clinical trials, drugs, therapy
Protein Interactions : CTD150290
Pharm GKB GenePA134928498
Clinical trialDUSP18
Miscellaneous
canSAR (ICR)DUSP18 (select the gene name)
HarmonizomeDUSP18
DataMed IndexDUSP18
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDUSP18
EVEXDUSP18
GoPubMedDUSP18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 15:53:56 CEST 2020
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