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DUSP8 (dual specificity phosphatase 8)

Identity

Alias_namesC11orf81
chromosome 11 open reading frame 81
Alias_symbol (synonym)HVH-5
HB5
FLJ42958
Other aliasHVH8
HGNC (Hugo) DUSP8
LocusID (NCBI) 1850
Atlas_Id 40378
Location 11p15.5  [Link to chromosome band 11p15]
Location_base_pair Starts at 1554051 and ends at 1571920 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DUSP8 (11p15.5) / MYEOV (11q13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;11)(p15;q13) DUSP8/MYEOV

External links

Nomenclature
HGNC (Hugo)DUSP8   3074
Cards
Entrez_Gene (NCBI)DUSP8  1850  dual specificity phosphatase 8
AliasesC11orf81; HB5; HVH-5; HVH8
GeneCards (Weizmann)DUSP8
Ensembl hg19 (Hinxton)ENSG00000184545 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184545 [Gene_View]  ENSG00000184545 [Sequence]  chr11:1554051-1571920 [Contig_View]  DUSP8 [Vega]
ICGC DataPortalENSG00000184545
TCGA cBioPortalDUSP8
AceView (NCBI)DUSP8
Genatlas (Paris)DUSP8
WikiGenes1850
SOURCE (Princeton)DUSP8
Genetics Home Reference (NIH)DUSP8
Genomic and cartography
GoldenPath hg38 (UCSC)DUSP8  -     chr11:1554051-1571920 -  11p15.5   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DUSP8  -     11p15.5   [Description]    (hg19-Feb_2009)
GoldenPathDUSP8 - 11p15.5 [CytoView hg19]  DUSP8 - 11p15.5 [CytoView hg38]
ImmunoBaseENSG00000184545
Mapping of homologs : NCBIDUSP8 [Mapview hg19]  DUSP8 [Mapview hg38]
OMIM602038   
Gene and transcription
Genbank (Entrez)AK124467 AK124948 BC038231 BC045110 BU740880
RefSeq transcript (Entrez)NM_004420
RefSeq genomic (Entrez)NC_000011 NT_187584 NT_187657
Consensus coding sequences : CCDS (NCBI)DUSP8
Cluster EST : UnigeneHs.41688 [ NCBI ]
CGAP (NCI)Hs.41688
Alternative Splicing GalleryENSG00000184545
Gene ExpressionDUSP8 [ NCBI-GEO ]   DUSP8 [ EBI - ARRAY_EXPRESS ]   DUSP8 [ SEEK ]   DUSP8 [ MEM ]
Gene Expression Viewer (FireBrowse)DUSP8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1850
GTEX Portal (Tissue expression)DUSP8
Human Protein AtlasENSG00000184545-DUSP8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13202   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13202  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13202
Splice isoforms : SwissVarQ13202
PhosPhoSitePlusQ13202
Domaine pattern : Prosite (Expaxy)RHODANESE_3 (PS50206)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_DUAL (PS50054)   
Domains : Interpro (EBI)Dual-sp_phosphatase_cat-dom    DUSP    MKP    Prot-tyrosine_phosphatase-like    Rhodanese-like_dom    Rhodanese-like_dom_sf    Tyr_Pase_AS    TYR_PHOSPHATASE_dom    TYR_PHOSPHATASE_DUAL_dom   
Domain families : Pfam (Sanger)DSPc (PF00782)    Rhodanese (PF00581)   
Domain families : Pfam (NCBI)pfam00782    pfam00581   
Domain families : Smart (EMBL)DSPc (SM00195)  RHOD (SM00450)  
Conserved Domain (NCBI)DUSP8
DMDM Disease mutations1850
Blocks (Seattle)DUSP8
PDB (RSDB)4JMK   
PDB Europe4JMK   
PDB (PDBSum)4JMK   
PDB (IMB)4JMK   
Structural Biology KnowledgeBase4JMK   
SCOP (Structural Classification of Proteins)4JMK   
CATH (Classification of proteins structures)4JMK   
SuperfamilyQ13202
Human Protein Atlas [tissue]ENSG00000184545-DUSP8 [tissue]
Peptide AtlasQ13202
HPRD03617
IPIIPI00012270   
Protein Interaction databases
DIP (DOE-UCLA)Q13202
IntAct (EBI)Q13202
FunCoupENSG00000184545
BioGRIDDUSP8
STRING (EMBL)DUSP8
ZODIACDUSP8
Ontologies - Pathways
QuickGOQ13202
Ontology : AmiGOinactivation of MAPK activity  protein tyrosine phosphatase activity  nucleus  cytoplasm  cytosol  protein dephosphorylation  protein tyrosine/serine/threonine phosphatase activity  dephosphorylation  phosphatase activity  MAP kinase tyrosine/serine/threonine phosphatase activity  peptidyl-tyrosine dephosphorylation  
Ontology : EGO-EBIinactivation of MAPK activity  protein tyrosine phosphatase activity  nucleus  cytoplasm  cytosol  protein dephosphorylation  protein tyrosine/serine/threonine phosphatase activity  dephosphorylation  phosphatase activity  MAP kinase tyrosine/serine/threonine phosphatase activity  peptidyl-tyrosine dephosphorylation  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkDUSP8
Atlas of Cancer Signalling NetworkDUSP8
Wikipedia pathwaysDUSP8
Orthology - Evolution
OrthoDB1850
GeneTree (enSembl)ENSG00000184545
Phylogenetic Trees/Animal Genes : TreeFamDUSP8
HOGENOMQ13202
Homologs : HomoloGeneDUSP8
Homology/Alignments : Family Browser (UCSC)DUSP8
Gene fusions - Rearrangements
Fusion : QuiverDUSP8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDUSP8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DUSP8
dbVarDUSP8
ClinVarDUSP8
1000_GenomesDUSP8 
Exome Variant ServerDUSP8
ExAC (Exome Aggregation Consortium)ENSG00000184545
GNOMAD BrowserENSG00000184545
Varsome BrowserDUSP8
Genetic variants : HAPMAP1850
Genomic Variants (DGV)DUSP8 [DGVbeta]
DECIPHERDUSP8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDUSP8 
Mutations
ICGC Data PortalDUSP8 
TCGA Data PortalDUSP8 
Broad Tumor PortalDUSP8
OASIS PortalDUSP8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDUSP8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDUSP8
Mutations and Diseases : HGMDDUSP8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DUSP8
DgiDB (Drug Gene Interaction Database)DUSP8
DoCM (Curated mutations)DUSP8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DUSP8 (select a term)
intoGenDUSP8
Cancer3DDUSP8(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602038   
Orphanet
DisGeNETDUSP8
MedgenDUSP8
Genetic Testing Registry DUSP8
NextProtQ13202 [Medical]
TSGene1850
GENETestsDUSP8
Target ValidationDUSP8
Huge Navigator DUSP8 [HugePedia]
snp3D : Map Gene to Disease1850
BioCentury BCIQDUSP8
ClinGenDUSP8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1850
Chemical/Pharm GKB GenePA27531
Clinical trialDUSP8
Miscellaneous
canSAR (ICR)DUSP8 (select the gene name)
DataMed IndexDUSP8
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDUSP8
EVEXDUSP8
GoPubMedDUSP8
iHOPDUSP8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:41:14 CET 2019
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