DYNLL1 (dynein light chain LC8-type 1)

2007-02-01  

Identity

HGNC
DYNLL1
LOCATION
12q24.31
LOCUSID
8655
ALIAS
DLC1,DLC8,DNCL1,DNCLC1,LC8,LC8a,PIN,hdlc1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8655
MIM: 601562
HGNC: 15476
Ensembl: ENSG00000088986

Variants:

dbSNP: 8655
ClinVar: 8655
TCGA: ENSG00000088986
COSMIC: DYNLL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000088986ENST00000242577P63167
ENSG00000088986ENST00000242577Q6FGH9
ENSG00000088986ENST00000392508P63167
ENSG00000088986ENST00000392508Q6FGH9
ENSG00000088986ENST00000392509P63167
ENSG00000088986ENST00000392509Q6FGH9
ENSG00000088986ENST00000548214F8VRV5
ENSG00000088986ENST00000548342P63167
ENSG00000088986ENST00000548342Q6FGH9
ENSG00000088986ENST00000549649F8VXI7
ENSG00000088986ENST00000549989P63167
ENSG00000088986ENST00000549989Q6FGH9
ENSG00000088986ENST00000550178F8VRV5
ENSG00000088986ENST00000550845F8VRV5
ENSG00000088986ENST00000552870F8VXL2

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vasopressin-regulated water reabsorptionKEGGko04962
Vasopressin-regulated water reabsorptionKEGGhsa04962
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Intraflagellar transportREACTOMER-HSA-5620924
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
Innate Immune SystemREACTOMER-HSA-168249
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Intrinsic Pathway for ApoptosisREACTOMER-HSA-109606
Activation of BH3-only proteinsREACTOMER-HSA-114452
Activation of BIM and translocation to mitochondriaREACTOMER-HSA-111446
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
COPI-mediated anterograde transportREACTOMER-HSA-6807878
AURKA Activation by TPX2REACTOMER-HSA-8854518
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-independent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811436
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
356965492022Dynein light chain LC8 alleviates nonalcoholic steatohepatitis by inhibiting NF-κB signaling and reducing oxidative stress.0
356965492022Dynein light chain LC8 alleviates nonalcoholic steatohepatitis by inhibiting NF-κB signaling and reducing oxidative stress.0
331711562020DYNLL1 is hypomethylated and upregulated in a tumor stage- and grade-dependent manner and associated with increased mortality in hepatocellular carcinoma.9
331711562020DYNLL1 is hypomethylated and upregulated in a tumor stage- and grade-dependent manner and associated with increased mortality in hepatocellular carcinoma.9
309828872019LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation.26
312668842019Systematic identification of recognition motifs for the hub protein LC8.17
315051702019Interactions between two regulatory proteins of microtubule dynamics, HDAC6, TPPP/p25, and the hub protein, DYNLL/LC8.2
309828872019LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation.26
312668842019Systematic identification of recognition motifs for the hub protein LC8.17
315051702019Interactions between two regulatory proteins of microtubule dynamics, HDAC6, TPPP/p25, and the hub protein, DYNLL/LC8.2
300182942018APC2 controls dendrite development by promoting microtubule dynamics.13
304642622018DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells.94
300182942018APC2 controls dendrite development by promoting microtubule dynamics.13
304642622018DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells.94
292407602017Novel linear motif filtering protocol reveals the role of the LC8 dynein light chain in the Hippo pathway.10

Citation

Dessen P

DYNLL1 (dynein light chain LC8-type 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45628/dynll1