Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DYNLL1 (dynein light chain LC8-type 1)

Identity

Alias_namesDNCL1
dynein, cytoplasmic, light polypeptide 1
Alias_symbol (synonym)hdlc1
DLC1
PIN
LC8
DLC8
Other aliasDNCLC1
LC8a
HGNC (Hugo) DYNLL1
LocusID (NCBI) 8655
Atlas_Id 45628
Location 12q24.31  [Link to chromosome band 12q24]
Location_base_pair Starts at 120496056 and ends at 120498495 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DYNLL1 (12q24.31) / AGFG1 (2q36.3)DYNLL1 (12q24.31) / COQ5 (12q24.31)DYNLL1 12q24.31 / COQ5 12q24.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  DYNLL1/COQ5 (12q24)

External links

Nomenclature
HGNC (Hugo)DYNLL1   15476
Cards
Entrez_Gene (NCBI)DYNLL1  8655  dynein light chain LC8-type 1
AliasesDLC1; DLC8; DNCL1; DNCLC1; 
LC8; LC8a; PIN; hdlc1
GeneCards (Weizmann)DYNLL1
Ensembl hg19 (Hinxton)ENSG00000088986 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000088986 [Gene_View]  ENSG00000088986 [Sequence]  chr12:120496056-120498495 [Contig_View]  DYNLL1 [Vega]
ICGC DataPortalENSG00000088986
TCGA cBioPortalDYNLL1
AceView (NCBI)DYNLL1
Genatlas (Paris)DYNLL1
WikiGenes8655
SOURCE (Princeton)DYNLL1
Genetics Home Reference (NIH)DYNLL1
Genomic and cartography
GoldenPath hg38 (UCSC)DYNLL1  -     chr12:120496056-120498495 +  12q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DYNLL1  -     12q24.31   [Description]    (hg19-Feb_2009)
GoldenPathDYNLL1 - 12q24.31 [CytoView hg19]  DYNLL1 - 12q24.31 [CytoView hg38]
ImmunoBaseENSG00000088986
Mapping of homologs : NCBIDYNLL1 [Mapview hg19]  DYNLL1 [Mapview hg38]
OMIM601562   
Gene and transcription
Genbank (Entrez)AK309022 AK311790 BC100289 BC104244 BC104245
RefSeq transcript (Entrez)NM_001037494 NM_001037495 NM_003746
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DYNLL1
Cluster EST : UnigeneHs.5120 [ NCBI ]
CGAP (NCI)Hs.5120
Alternative Splicing GalleryENSG00000088986
Gene ExpressionDYNLL1 [ NCBI-GEO ]   DYNLL1 [ EBI - ARRAY_EXPRESS ]   DYNLL1 [ SEEK ]   DYNLL1 [ MEM ]
Gene Expression Viewer (FireBrowse)DYNLL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8655
GTEX Portal (Tissue expression)DYNLL1
Human Protein AtlasENSG00000088986-DYNLL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63167   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP63167  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63167
Splice isoforms : SwissVarP63167
PhosPhoSitePlusP63167
Domaine pattern : Prosite (Expaxy)DYNEIN_LIGHT_1 (PS01239)   
Domains : Interpro (EBI)DLC_sf    Dynein_light_1/2_CS    Dynein_light_chain_typ-1/2   
Domain families : Pfam (Sanger)Dynein_light (PF01221)   
Domain families : Pfam (NCBI)pfam01221   
Domain families : Smart (EMBL)Dynein_light (SM01375)  
Conserved Domain (NCBI)DYNLL1
DMDM Disease mutations8655
Blocks (Seattle)DYNLL1
PDB (RSDB)1CMI    3ZKE    3ZKF   
PDB Europe1CMI    3ZKE    3ZKF   
PDB (PDBSum)1CMI    3ZKE    3ZKF   
PDB (IMB)1CMI    3ZKE    3ZKF   
Structural Biology KnowledgeBase1CMI    3ZKE    3ZKF   
SCOP (Structural Classification of Proteins)1CMI    3ZKE    3ZKF   
CATH (Classification of proteins structures)1CMI    3ZKE    3ZKF   
SuperfamilyP63167
Human Protein Atlas [tissue]ENSG00000088986-DYNLL1 [tissue]
Peptide AtlasP63167
HPRD03334
IPIIPI00019329   IPI01021760   IPI01020853   IPI01021597   
Protein Interaction databases
DIP (DOE-UCLA)P63167
IntAct (EBI)P63167
FunCoupENSG00000088986
BioGRIDDYNLL1
STRING (EMBL)DYNLL1
ZODIACDYNLL1
Ontologies - Pathways
QuickGOP63167
Ontology : AmiGOG2/M transition of mitotic cell cycle  kinetochore  protein binding  nucleus  cytoplasm  mitochondrion  centrosome  cytosol  cytoplasmic dynein complex  cytoplasmic dynein complex  cytoplasmic dynein complex  microtubule  plasma membrane  cilium  ER to Golgi vesicle-mediated transport  apoptotic process  spermatid development  protein C-terminus binding  COP9 signalosome  ATP-dependent microtubule motor activity, plus-end-directed  regulation of G2/M transition of mitotic cell cycle  membrane  viral process  macroautophagy  antigen processing and presentation of exogenous peptide antigen via MHC class II  enzyme binding  protein domain specific binding  substantia nigra development  nitric-oxide synthase regulator activity  dynein complex  intraciliary retrograde transport  intraciliary transport involved in cilium assembly  positive regulation of insulin secretion involved in cellular response to glucose stimulus  negative regulation of phosphorylation  protein homodimerization activity  neutrophil degranulation  motile cilium assembly  dynein intermediate chain binding  protein heterodimerization activity  dynein light intermediate chain binding  tertiary granule membrane  mitotic spindle  scaffold protein binding  ciliary tip  ciliary basal body-plasma membrane docking  ficolin-1-rich granule membrane  positive regulation of non-motile cilium assembly  axon cytoplasm  positive regulation of ATP-dependent microtubule motor activity, plus-end-directed  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  kinetochore  protein binding  nucleus  cytoplasm  mitochondrion  centrosome  cytosol  cytoplasmic dynein complex  cytoplasmic dynein complex  cytoplasmic dynein complex  microtubule  plasma membrane  cilium  ER to Golgi vesicle-mediated transport  apoptotic process  spermatid development  protein C-terminus binding  COP9 signalosome  ATP-dependent microtubule motor activity, plus-end-directed  regulation of G2/M transition of mitotic cell cycle  membrane  viral process  macroautophagy  antigen processing and presentation of exogenous peptide antigen via MHC class II  enzyme binding  protein domain specific binding  substantia nigra development  nitric-oxide synthase regulator activity  dynein complex  intraciliary retrograde transport  intraciliary transport involved in cilium assembly  positive regulation of insulin secretion involved in cellular response to glucose stimulus  negative regulation of phosphorylation  protein homodimerization activity  neutrophil degranulation  motile cilium assembly  dynein intermediate chain binding  protein heterodimerization activity  dynein light intermediate chain binding  tertiary granule membrane  mitotic spindle  scaffold protein binding  ciliary tip  ciliary basal body-plasma membrane docking  ficolin-1-rich granule membrane  positive regulation of non-motile cilium assembly  axon cytoplasm  positive regulation of ATP-dependent microtubule motor activity, plus-end-directed  
Pathways : KEGGVasopressin-regulated water reabsorption   
NDEx NetworkDYNLL1
Atlas of Cancer Signalling NetworkDYNLL1
Wikipedia pathwaysDYNLL1
Orthology - Evolution
OrthoDB8655
GeneTree (enSembl)ENSG00000088986
Phylogenetic Trees/Animal Genes : TreeFamDYNLL1
HOGENOMP63167
Homologs : HomoloGeneDYNLL1
Homology/Alignments : Family Browser (UCSC)DYNLL1
Gene fusions - Rearrangements
Fusion : MitelmanDYNLL1/COQ5 [12q24.31/12q24.31]  
Fusion PortalDYNLL1 12q24.31 COQ5 12q24.31 HNSC
Fusion Cancer (Beijing)DYNLL1 [12q24.31]  -  AGFG1 [2q36.3]  [FUSC004668]
Fusion : QuiverDYNLL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDYNLL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DYNLL1
dbVarDYNLL1
ClinVarDYNLL1
1000_GenomesDYNLL1 
Exome Variant ServerDYNLL1
ExAC (Exome Aggregation Consortium)ENSG00000088986
GNOMAD BrowserENSG00000088986
Varsome BrowserDYNLL1
Genetic variants : HAPMAP8655
Genomic Variants (DGV)DYNLL1 [DGVbeta]
DECIPHERDYNLL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDYNLL1 
Mutations
ICGC Data PortalDYNLL1 
TCGA Data PortalDYNLL1 
Broad Tumor PortalDYNLL1
OASIS PortalDYNLL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDYNLL1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDYNLL1
Mutations and Diseases : HGMDDYNLL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DYNLL1
DgiDB (Drug Gene Interaction Database)DYNLL1
DoCM (Curated mutations)DYNLL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DYNLL1 (select a term)
intoGenDYNLL1
Cancer3DDYNLL1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601562   
Orphanet
DisGeNETDYNLL1
MedgenDYNLL1
Genetic Testing Registry DYNLL1
NextProtP63167 [Medical]
TSGene8655
GENETestsDYNLL1
Target ValidationDYNLL1
Huge Navigator DYNLL1 [HugePedia]
snp3D : Map Gene to Disease8655
BioCentury BCIQDYNLL1
ClinGenDYNLL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8655
Chemical/Pharm GKB GenePA134972261
Clinical trialDYNLL1
Miscellaneous
canSAR (ICR)DYNLL1 (select the gene name)
DataMed IndexDYNLL1
Probes
Litterature
PubMed151 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDYNLL1
EVEXDYNLL1
GoPubMedDYNLL1
iHOPDYNLL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:41:17 CET 2019
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