Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

DYNLL2 (dynein light chain LC8-type 2)

Identity

Alias_symbol (synonym)MGC17810
Dlc2
DNCL1B
RSPH22
Other alias
HGNC (Hugo) DYNLL2
LocusID (NCBI) 140735
Atlas_Id 62693
Location 17q22  [Link to chromosome band 17q22]
Location_base_pair Starts at 58083419 and ends at 58090257 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DYNLL2 (17q22) / SEPT4 (17q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DYNLL2   24596
Cards
Entrez_Gene (NCBI)DYNLL2  140735  dynein light chain LC8-type 2
AliasesDNCL1B; Dlc2; RSPH22
GeneCards (Weizmann)DYNLL2
Ensembl hg19 (Hinxton)ENSG00000264364 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000264364 [Gene_View]  ENSG00000264364 [Sequence]  chr17:58083419-58090257 [Contig_View]  DYNLL2 [Vega]
ICGC DataPortalENSG00000264364
TCGA cBioPortalDYNLL2
AceView (NCBI)DYNLL2
Genatlas (Paris)DYNLL2
WikiGenes140735
SOURCE (Princeton)DYNLL2
Genetics Home Reference (NIH)DYNLL2
Genomic and cartography
GoldenPath hg38 (UCSC)DYNLL2  -     chr17:58083419-58090257 +  17q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DYNLL2  -     17q22   [Description]    (hg19-Feb_2009)
GoldenPathDYNLL2 - 17q22 [CytoView hg19]  DYNLL2 - 17q22 [CytoView hg38]
ImmunoBaseENSG00000264364
Mapping of homologs : NCBIDYNLL2 [Mapview hg19]  DYNLL2 [Mapview hg38]
OMIM608942   
Gene and transcription
Genbank (Entrez)AF086304 AF112997 AK312125 BC010744 BF528423
RefSeq transcript (Entrez)NM_080677
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DYNLL2
Cluster EST : UnigeneHs.720595 [ NCBI ]
CGAP (NCI)Hs.720595
Alternative Splicing GalleryENSG00000264364
Gene ExpressionDYNLL2 [ NCBI-GEO ]   DYNLL2 [ EBI - ARRAY_EXPRESS ]   DYNLL2 [ SEEK ]   DYNLL2 [ MEM ]
Gene Expression Viewer (FireBrowse)DYNLL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)140735
GTEX Portal (Tissue expression)DYNLL2
Human Protein AtlasENSG00000264364-DYNLL2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96FJ2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96FJ2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96FJ2
Splice isoforms : SwissVarQ96FJ2
PhosPhoSitePlusQ96FJ2
Domaine pattern : Prosite (Expaxy)DYNEIN_LIGHT_1 (PS01239)   
Domains : Interpro (EBI)DLC_sf    Dynein_light_1/2_CS    Dynein_light_chain_typ-1/2   
Domain families : Pfam (Sanger)Dynein_light (PF01221)   
Domain families : Pfam (NCBI)pfam01221   
Domain families : Smart (EMBL)Dynein_light (SM01375)  
Conserved Domain (NCBI)DYNLL2
DMDM Disease mutations140735
Blocks (Seattle)DYNLL2
PDB (RSDB)2XQQ    3P8M    4D07   
PDB Europe2XQQ    3P8M    4D07   
PDB (PDBSum)2XQQ    3P8M    4D07   
PDB (IMB)2XQQ    3P8M    4D07   
Structural Biology KnowledgeBase2XQQ    3P8M    4D07   
SCOP (Structural Classification of Proteins)2XQQ    3P8M    4D07   
CATH (Classification of proteins structures)2XQQ    3P8M    4D07   
SuperfamilyQ96FJ2
Human Protein Atlas [tissue]ENSG00000264364-DYNLL2 [tissue]
Peptide AtlasQ96FJ2
HPRD06489
IPIIPI00062037   
Protein Interaction databases
DIP (DOE-UCLA)Q96FJ2
IntAct (EBI)Q96FJ2
FunCoupENSG00000264364
BioGRIDDYNLL2
STRING (EMBL)DYNLL2
ZODIACDYNLL2
Ontologies - Pathways
QuickGOQ96FJ2
Ontology : AmiGOprotein binding  nucleus  centrosome  cytosol  cytoplasmic dynein complex  microtubule  plasma membrane  cilium  ER to Golgi vesicle-mediated transport  ATP-dependent microtubule motor activity, plus-end-directed  postsynaptic density  membrane  macroautophagy  antigen processing and presentation of exogenous peptide antigen via MHC class II  dynein complex  myosin V complex  intraciliary transport involved in cilium assembly  protein homodimerization activity  dynein intermediate chain binding  protein heterodimerization activity  dynein light intermediate chain binding  scaffold protein binding  ciliary tip  postsynapse  postsynapse  glutamatergic synapse  glutamatergic synapse  positive regulation of ATP-dependent microtubule motor activity, plus-end-directed  
Ontology : EGO-EBIprotein binding  nucleus  centrosome  cytosol  cytoplasmic dynein complex  microtubule  plasma membrane  cilium  ER to Golgi vesicle-mediated transport  ATP-dependent microtubule motor activity, plus-end-directed  postsynaptic density  membrane  macroautophagy  antigen processing and presentation of exogenous peptide antigen via MHC class II  dynein complex  myosin V complex  intraciliary transport involved in cilium assembly  protein homodimerization activity  dynein intermediate chain binding  protein heterodimerization activity  dynein light intermediate chain binding  scaffold protein binding  ciliary tip  postsynapse  postsynapse  glutamatergic synapse  glutamatergic synapse  positive regulation of ATP-dependent microtubule motor activity, plus-end-directed  
NDEx NetworkDYNLL2
Atlas of Cancer Signalling NetworkDYNLL2
Wikipedia pathwaysDYNLL2
Orthology - Evolution
OrthoDB140735
GeneTree (enSembl)ENSG00000264364
Phylogenetic Trees/Animal Genes : TreeFamDYNLL2
HOGENOMQ96FJ2
Homologs : HomoloGeneDYNLL2
Homology/Alignments : Family Browser (UCSC)DYNLL2
Gene fusions - Rearrangements
Fusion : QuiverDYNLL2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDYNLL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DYNLL2
dbVarDYNLL2
ClinVarDYNLL2
1000_GenomesDYNLL2 
Exome Variant ServerDYNLL2
ExAC (Exome Aggregation Consortium)ENSG00000264364
GNOMAD BrowserENSG00000264364
Varsome BrowserDYNLL2
Genetic variants : HAPMAP140735
Genomic Variants (DGV)DYNLL2 [DGVbeta]
DECIPHERDYNLL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDYNLL2 
Mutations
ICGC Data PortalDYNLL2 
TCGA Data PortalDYNLL2 
Broad Tumor PortalDYNLL2
OASIS PortalDYNLL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDYNLL2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDYNLL2
Mutations and Diseases : HGMDDYNLL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DYNLL2
DgiDB (Drug Gene Interaction Database)DYNLL2
DoCM (Curated mutations)DYNLL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DYNLL2 (select a term)
intoGenDYNLL2
Cancer3DDYNLL2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608942   
Orphanet
DisGeNETDYNLL2
MedgenDYNLL2
Genetic Testing Registry DYNLL2
NextProtQ96FJ2 [Medical]
TSGene140735
GENETestsDYNLL2
Target ValidationDYNLL2
Huge Navigator DYNLL2 [HugePedia]
snp3D : Map Gene to Disease140735
BioCentury BCIQDYNLL2
ClinGenDYNLL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD140735
Chemical/Pharm GKB GenePA142671920
Clinical trialDYNLL2
Miscellaneous
canSAR (ICR)DYNLL2 (select the gene name)
DataMed IndexDYNLL2
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDYNLL2
EVEXDYNLL2
GoPubMedDYNLL2
iHOPDYNLL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Sep 3 15:26:22 CEST 2019

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.