DYNLT1 (dynein light chain Tctex-type 1)

2017-10-01  

Identity

HGNC
DYNLT1
LOCATION
6q25.3
LOCUSID
6993
ALIAS
CW-1,TCTEL1,TCTEX1,tctex-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6993
MIM: 601554
HGNC: 11697
Ensembl: ENSG00000146425

Variants:

dbSNP: 6993
ClinVar: 6993
TCGA: ENSG00000146425
COSMIC: DYNLT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146425ENST00000367089P63172

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
213940822011Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors.94
211669732011Identification of the dynein light chains required for human papillomavirus infection.58
145834452003Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension.49
117519372002Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis.38
217003582011A role for Tctex-1 (DYNLT1) in controlling primary cilium length.21
169563852006Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin.20
186478392008D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein.20
259446612015Chlamydia trachomatis inclusion membrane protein CT850 interacts with the dynein light chain DYNLT1 (Tctex1).20
217678582011The interaction of flavivirus M protein with light chain Tctex-1 of human dynein plays a role in late stages of virus replication.14
212627672011Tctex-1, a novel interaction partner of Rab3D, is required for osteoclastic bone resorption.10

Citation

Dessen P

DYNLT1 (dynein light chain Tctex-type 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57209/dynlt1