DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2)

2006-10-01  

Identity

HGNC
DYRK2
LOCATION
12q15
LOCUSID
8445
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8445
MIM: 603496
HGNC: 3093
Ensembl: ENSG00000127334

Variants:

dbSNP: 8445
ClinVar: 8445
TCGA: ENSG00000127334
COSMIC: DYRK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127334ENST00000319833A0A0A0MR56
ENSG00000127334ENST00000344096Q92630
ENSG00000127334ENST00000393555Q92630
ENSG00000127334ENST00000542503F5H5L5
ENSG00000127334ENST00000543747F5GXG1

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
173499582007DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage.87
192873802009Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase.75
223073292012DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells.37
199658712010ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage.27
233622802013Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation.25
237918822013DYRK2 controls the epithelial-mesenchymal transition in breast cancer by degrading Snail.19
228782632012Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways.17
244380552014Stability of the human pregnane X receptor is regulated by E3 ligase UBR5 and serine/threonine kinase DYRK2.13
250959822014Downregulation of DYRK2 can be a predictor of recurrence in early stage breast cancer.8
268042442016Downregulated DYRK2 expression is associated with poor prognosis and Oxaliplatin resistance in hepatocellular carcinoma.8

Citation

Dessen P

DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43236/dyrk2