Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DYRK4 (dual specificity tyrosine phosphorylation regulated kinase 4)

Identity

Alias_namesdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
dual specificity tyrosine-(Y)-phosphorylation regulated kinase 4
Other alias-
HGNC (Hugo) DYRK4
LocusID (NCBI) 8798
Atlas_Id 43238
Location 12p13.32  [Link to chromosome band 12p13]
Location_base_pair Starts at 4590072 and ends at 4613888 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DYRK4   3095
Cards
Entrez_Gene (NCBI)DYRK4  8798  dual specificity tyrosine phosphorylation regulated kinase 4
Aliases
GeneCards (Weizmann)DYRK4
Ensembl hg19 (Hinxton)ENSG00000010219 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000010219 [Gene_View]  ENSG00000010219 [Sequence]  chr12:4590072-4613888 [Contig_View]  DYRK4 [Vega]
ICGC DataPortalENSG00000010219
TCGA cBioPortalDYRK4
AceView (NCBI)DYRK4
Genatlas (Paris)DYRK4
WikiGenes8798
SOURCE (Princeton)DYRK4
Genetics Home Reference (NIH)DYRK4
Genomic and cartography
GoldenPath hg38 (UCSC)DYRK4  -     chr12:4590072-4613888 +  12p13.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DYRK4  -     12p13.32   [Description]    (hg19-Feb_2009)
GoldenPathDYRK4 - 12p13.32 [CytoView hg19]  DYRK4 - 12p13.32 [CytoView hg38]
ImmunoBaseENSG00000010219
Mapping of homologs : NCBIDYRK4 [Mapview hg19]  DYRK4 [Mapview hg38]
OMIM609181   
Gene and transcription
Genbank (Entrez)AA524246 AF263541 AK292322 AK298979 AK303744
RefSeq transcript (Entrez)NM_001282285 NM_001282286 NM_001371301 NM_003845
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DYRK4
Cluster EST : UnigeneHs.439530 [ NCBI ]
CGAP (NCI)Hs.439530
Alternative Splicing GalleryENSG00000010219
Gene ExpressionDYRK4 [ NCBI-GEO ]   DYRK4 [ EBI - ARRAY_EXPRESS ]   DYRK4 [ SEEK ]   DYRK4 [ MEM ]
Gene Expression Viewer (FireBrowse)DYRK4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8798
GTEX Portal (Tissue expression)DYRK4
Human Protein AtlasENSG00000010219-DYRK4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NR20   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NR20  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NR20
Splice isoforms : SwissVarQ9NR20
PhosPhoSitePlusQ9NR20
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)DYRK4
DMDM Disease mutations8798
Blocks (Seattle)DYRK4
SuperfamilyQ9NR20
Human Protein Atlas [tissue]ENSG00000010219-DYRK4 [tissue]
Peptide AtlasQ9NR20
HPRD10926
IPIIPI00396286   IPI00555676   IPI00847666   IPI01015498   IPI01013316   IPI01013669   IPI01014254   IPI01011065   
Protein Interaction databases
DIP (DOE-UCLA)Q9NR20
IntAct (EBI)Q9NR20
FunCoupENSG00000010219
BioGRIDDYRK4
STRING (EMBL)DYRK4
ZODIACDYRK4
Ontologies - Pathways
QuickGOQ9NR20
Ontology : AmiGOprotein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytoplasm  cytoskeleton  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  peptidyl-tyrosine phosphorylation  intracellular membrane-bounded organelle  metal ion binding  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytoplasm  cytoskeleton  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  peptidyl-tyrosine phosphorylation  intracellular membrane-bounded organelle  metal ion binding  
NDEx NetworkDYRK4
Atlas of Cancer Signalling NetworkDYRK4
Wikipedia pathwaysDYRK4
Orthology - Evolution
OrthoDB8798
GeneTree (enSembl)ENSG00000010219
Phylogenetic Trees/Animal Genes : TreeFamDYRK4
HOGENOMQ9NR20
Homologs : HomoloGeneDYRK4
Homology/Alignments : Family Browser (UCSC)DYRK4
Gene fusions - Rearrangements
Fusion : QuiverDYRK4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDYRK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DYRK4
dbVarDYRK4
ClinVarDYRK4
1000_GenomesDYRK4 
Exome Variant ServerDYRK4
ExAC (Exome Aggregation Consortium)ENSG00000010219
GNOMAD BrowserENSG00000010219
Varsome BrowserDYRK4
Genetic variants : HAPMAP8798
Genomic Variants (DGV)DYRK4 [DGVbeta]
DECIPHERDYRK4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDYRK4 
Mutations
ICGC Data PortalDYRK4 
TCGA Data PortalDYRK4 
Broad Tumor PortalDYRK4
OASIS PortalDYRK4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDYRK4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDYRK4
Mutations and Diseases : HGMDDYRK4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DYRK4
DgiDB (Drug Gene Interaction Database)DYRK4
DoCM (Curated mutations)DYRK4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DYRK4 (select a term)
intoGenDYRK4
Cancer3DDYRK4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609181   
Orphanet
DisGeNETDYRK4
MedgenDYRK4
Genetic Testing Registry DYRK4
NextProtQ9NR20 [Medical]
TSGene8798
GENETestsDYRK4
Target ValidationDYRK4
Huge Navigator DYRK4 [HugePedia]
snp3D : Map Gene to Disease8798
BioCentury BCIQDYRK4
ClinGenDYRK4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8798
Chemical/Pharm GKB GenePA27552
Clinical trialDYRK4
Miscellaneous
canSAR (ICR)DYRK4 (select the gene name)
DataMed IndexDYRK4
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDYRK4
EVEXDYRK4
GoPubMedDYRK4
iHOPDYRK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:41:19 CET 2019
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